FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
https://doi.org/10.15789/1563-0625-2019-3-517-526
Abstract
To evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD. The comparison group consisted of seven children born at 22-27 weeks of gestational age without signs of BPD. Relative numbers of lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+, CD4+CD25+), and monocytes (CD14+CD64+, CD14+HLA-DR+) were determined by flow cytometry. The level of cytokines (IL-6, IL-8, IL-4) was measured by enzyme immunoassay technique. The features of immune status in children with BPD of severe, mild and moderate severity were discerned. It was found that the predictors of severe BPD development in the children born at very early terms, are: increased content of IL-8 at birth and at the age of 1 month, reduced level of expression on monocytes (CD64, HLA-DR) on the 1 month of life, and CD14+CD64+ cells at 38-40 weeks post conception. The revealed features of immune status in newborns with BPD can be used to assess the effectiveness of the therapy, which requires further research in this direction.
About the Authors
G. N. Chistyakova
Ural Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Head, Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics
Ekaterinburg
I. I. Remizova
Ural Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
PhD (Biology), Senior Research Associate, Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics
620089, Ekaterinburg, Rodonitovaya str., 3/1-45.
Phone: 7 (343) 371-28-30.
L. S. Ustyantseva
Ural Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
Junior Research Associate, Department of Physiology and Pathology of Newborns and Infants
Ekaterinburg
K. P. Shamova
Ural Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
Anesthesiologist, Intensive Care Department for Newborns, Postgraduate Student
Ekaterinburg
S. V. Bychkova
Ural Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Department of Reproductive Function Preservation
Ekaterinburg
M. A. Botskovskaya
Ural Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
Neonatologist, Department of Intensive Care for Newborns, Postgraduate Student
Ekaterinburg
I. A. Gazieva
Ural Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
PhD, MD (Biology), Leading Research Associate, Department of Antenatal Labor Protection
Ekaterinburg
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Review
For citations:
Chistyakova G.N., Remizova I.I., Ustyantseva L.S., Shamova K.P., Bychkova S.V., Botskovskaya M.A., Gazieva I.A. FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY. Medical Immunology (Russia). 2019;21(3):517-526. (In Russ.) https://doi.org/10.15789/1563-0625-2019-3-517-526
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