ПУРИНЕРГИЧЕСКАЯ РЕГУЛЯЦИЯ ОСНОВНЫХ ФИЗИОЛОГИЧЕСКИХ И ПАТОЛОГИЧЕСКИХ ПРОЦЕССОВ
Аннотация
В последние годы ведется активное изучение значимости пуринергического сигналинга в патогенезе широкого спектра заболеваний и патологических состояний, к числу которых относятся регуляция инфекционного и неинфекционного воспаления, опухолевого роста и метастазирования, реакций отторжения трансплантата, аутоиммунных заболеваний, кальцификации элементов сердечно-сосудистой системы и т.д. Было показано, что пуринергическая система осуществляет тонкую регуляцию функций клеток иммунной системы аналогично цитокиновой и хемокиновой секреции, удалению внутриклеточных патогенов и механизмов клеточной гибели. Основываясь на понимании механизмов развития этих состояний, в том числе и участии пуринергической системы в их регуляции, разрабатываются новые подходы к терапии и профилактике. Анализу достижений последнего времени в участии пуринергической регуляции в основных патологических состояниях и заболеваниях, а также трендам в разработке терапевтических подходов на основании полученных знаний посвящен данный обзор.
Об авторах
А. С. Головкин
ФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова»
Россия
Россия
д.м.н., руководитель группы, Институт молекулярной биологии и генетики,
197341, Санкт-Петербург, ул. Аккуратова, 2
И. А. Асадуллина
ФГБНУ «Институт экспериментальной медицины»
Россия
Россия
младший научный сотрудник отдела иммунологии,
Санкт-Петербург
И. В. Кудрявцев
ФГБНУ «Институт экспериментальной медицины»;
ГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения РФ
Россия
Россия
к.б.н., старший научный сотрудник отдела иммунологии;
доцент кафедры иммунологии,
Санкт-Петербург
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При поддержке: РФФИ
Для цитирования:
Головкин А.С., Асадуллина И.А., Кудрявцев И.В. ПУРИНЕРГИЧЕСКАЯ РЕГУЛЯЦИЯ ОСНОВНЫХ ФИЗИОЛОГИЧЕСКИХ И ПАТОЛОГИЧЕСКИХ ПРОЦЕССОВ. Медицинская иммунология. 2018;20(4):463-476. https://doi.org/10.15789/1563-0625-2018-4-463-476
For citation:
Golovkin A.S., Asadullina I.A., Kudryavtsev I.V. PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES. Medical Immunology (Russia). 2018;20(4):463-476. (In Russ.) https://doi.org/10.15789/1563-0625-2018-4-463-476
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