DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
https://doi.org/10.15789/1563-0625-2008-2-3-229-238
Abstract
Abstract. The aim of this study was to detect some features of autoreactive IgM production that interact with IgGs and normal human cellular antigens in blood sera of patients with acute respiratory viral infections caused by various factors, dependent on their age and clinical features of disease. The antibody concentrations were determined by immunoenzyme technique in paired serum samples from 750 patients and single specimens from 97 healthy persons. The results of analysis have shown that the studied types of autoreactive IgM represent a normal component of humoral immunity, since they are detectable in sufficient number of normal sera from healthy persons over 3 years old. In acute respiratory viral infections of different etiology, the rates of appropriate seroconversions comprised 0 to 16% for age cohort of < 3 years old. Incidence of seroconversions reached 37% among older children and adult patients with respiratory syncitial virus (RSV), or adenoviral infection, thus being 1.7 to 5.1-fold higher than in patients with influenza A, or B, or parainfluenza. In cases of clinical complications of RSV or parainfluenza infections (i.e., respiratory tract obstruction, or pneumonia), the rates of seroconversions to autoreactive IgMs was 1.4 to1.8-fold higher than among the patients with uncomplicated clinical course of these infections. (Med. Immunol., 2008, vol. 10, N 2-3, pp 229-238).
About the Authors
V. Z. Krivitskaya
ГУ Научно-исследовательский институт гриппа РАМН, Санкт-Петербург
Russian Federation
Russian Federation
M. V. Sverlova
ГУ Научно-исследовательский институт гриппа РАМН, Санкт-Петербург
Russian Federation
Russian Federation
V. F. Sukhovetskaya
ГУ Научно-исследовательский институт гриппа РАМН, Санкт-Петербург
Russian Federation
Russian Federation
N. I. Lvov
Военно-медицинская академия им. С.М. Кирова, Санкт-Петербург
Russian Federation
Russian Federation
I. A. Vassilieva
ГУ Научно-исследовательский институт гриппа РАМН, Санкт-Петербург
Russian Federation
Russian Federation
A. A. Sominina
ГУ Научно-исследовательский институт гриппа РАМН, Санкт-Петербург
Russian Federation
Russian Federation
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Review
For citations:
Krivitskaya V.Z., Sverlova M.V., Sukhovetskaya V.F., Lvov N.I., Vassilieva I.A., Sominina A.A. DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS. Medical Immunology (Russia). 2008;10(2-3):229-238. (In Russ.) https://doi.org/10.15789/1563-0625-2008-2-3-229-238
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