IMMUNITY AND INFECTION IN WOMEN WITH HYPERPLASTIC STATES OF IMMUNE SYSTEM

Abstract. One hundred and ninety-nine patients with hyperplastic processes of reproductive system were examined, and 131 (66.16%) of them were found to be infected with Chlamydia or Ureaplasma. The mean age of female patients was 42,7±1,35 years. Different infectious agents (e.g. Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis) were identified in cervical canal of uterine cervix and surgical specimens (biopsy samples of excised myoma, adenomyosis or endometrial hyperplasia). The infected patients were found to have decreased monocytes and neutrophils in blood counts, lower phagocytic activity of monocytes and neutrophils, and decreased bactericidal activity of leukocytes. Other findings included lower CD20+, CD8+ and rFAS CD 95 lymphocytes. Assessment of cytokine-synthesizing activity of CD3+ lymphocytes showed a decrease in both spontaneous and stimulated response (р < 0,001). A weakest spontaneous and stimulated response was found in CD3+/IL-4+ lymphocytes. Analysis of results obtained shows systemic immune disorders and impaired cytokine-synthesizing activity of CD3+ lymphocytes correlating with infection factors in the women with hyperplastic processes of reproductive system. (Med. Immunol., 2008, vol. 10, N 2-3, pp 223-228).

1. Башмакова М.А., Савичева А.М. Генитальные микоплазмы и микоплазменные инфекции // Трудный пациент. – 2006. – Т. 4, № 2. – С. 24-30.

2. Карамова А.Э., Поляков А.В., Комарова Н.В., Хамаганова И.В. Цервицит и Ureaplasma urealyticum // Рос. журн. кожных и венер. болезней. – 2005. – № 6. – С. 9-13.

3. Мазуров Д.В., Дамбаева С.В., Пинегин Б.В. Оценка внутриклеточного киллинга стафилококка фагоцитами периферической крови с помощью проточной цитометрии // Иммунология. – 2000. – № 2. – С. 57-59.

4. Потехин О.Е., Малышев В.С. Роль инфекции Chlamydiae pneumoniae в развитии атеросклероза сосудов сердца // Кремлевская медицина. Клинический вестник. – 1998. – № 1. – С. 13-17.

5. Салехов С.А., Андриевская М.А., Корабельникова И.А., Решетникова Г.В., Нирозник В.В. О диагностике хламидийной и микоплазменной урогенитальной инфекции / Охрана здоровья матери и ребенка, 2000. Роль инфекции в патологии репродуктивной системы женщины, плода и новорожденного // Сб. тезисов. – М., 2000. – С. 260-261.

6. Сухих Г.Т., Ванько Л.В. Механизмы иммунной защиты при острых и хронических заболеваниях органов репродуктивной системы // Акушерство и гинекология. – 2006. – Приложение. – С. 17-24.

7. Цинкернагель Р. Об иммунологической памяти // Казанский медицинский журнал. – 2007. – Т. 88, № 1. – С. 1-4.

8. Anderson J.I., Muhlestein J.B., Carlquist J., Allen A., Trehan S., Nielson C., Hall S., Brady J., Egger M., Horue B., Lim T. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: the azithromycin in coronary artery disease: elimination of myocardial infection with Chlamydia (ACADEMIC) study // Circulation. – 1999. – Vol. 99, N 12. – P. 1540-1547.

9. Engelmann M.G., Nikol S. Atherosclerosis as inflammatory disease: Impact of Chlamydia pneumoniae and latest insights in whether or not prevention using antibiotics makes sense // e-Journal of Cardiology Practice. – 2003. – Vol. 2, N 7.

10. Gupta S. Chronic infection in the aetiology of atherosclerosis – focus on Chlamydia pneumoniae [The John French Memorial Lecture] // Atherosclerosis. – 1999. – Vol. 143. – P. 1-6.