DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS
https://doi.org/10.15789/1563-0625-2017-6-763-770
Abstract
HLA-G is the main molecule through which provides tolerance of maternal immune microenvironment to the semi-allogeneic embryo. Polymorphic variant of 14-bp ins/del in the HLA-G 3’UTR gene affects stability and expression of specific mRNA and, thereby, efficiency of immune rejection blockade of the semi-allogeneic embryo. Immune interactions in the “mother – fetus”system can cause teratogenic effects. Congenital heart defects are the dominant pathology among congenital malformations of the fetus and newborns. The aim of the study was to search possible associations between polymorphic 14-bp ins/del variants of maternal HLA-G 3’UTR gene, and reproductive losses or congenital heart defects in their children. Subjects and Methods. We have examined 103 women who had children with congenital heart defects, 21 women with reproductive losses at up to 9 weeks of pregnancy, 101 women with two or more healthy children. Results. It was revealed that the minor homozygous genotype HLA-G 3’UTR 14-bp ins/14-bp ins (OR = 5.25; 95% CI = 1.31-21.11), and allele HLA-G 3’UTR 14-bp ins (OR = 2.34; 95% CI = 1.13-4.84) were markers of early reproductive loss in women. Polymorphic variant of the 14-bp ins/14-bp del gene variant of HLA-G 3’UTR in the mothers was not significantly associated with birth of infants with congenital heart defects.
About the Authors
A. V. Shabaldin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
PhD, MD (Medicine), Leading Research Associate, Laboratory of cell Technologies, Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
PhD, MD (Medicine), Leading Research Associate, Laboratory of cell Technologies, Research Institute for Complex Issues of Cardiovascular Diseases
A. V. Tsepokina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Junior Research Associte, Laboratory of Genomic Medicine, Research Institute for Complex Issues of Cardiovascular Diseases
650002, Russian Federation, Kemerovo, Sosnoviy blvd, 6.
S. A. Shmulevich
Kemerovo L.S. Barbarash Cardiological Dispensarys
Russian Federation
Head, Pediatric Department, Kemerovo L.S. Barbarash Cardiological Dispensarys
Russian Federation
Head, Pediatric Department, Kemerovo L.S. Barbarash Cardiological Dispensarys
A. V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
PhD (Medicine), Head, Laboratory of Genomic Medicine, Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
PhD (Medicine), Head, Laboratory of Genomic Medicine, Research Institute for Complex Issues of Cardiovascular Diseases
P. M. Kryukov
Children City Clinical Hospital No. 5
Russian Federation
PhD (Medicine), Head, Department for Newborn Children, Children City Clinical Hospital No. 5
Russian Federation
PhD (Medicine), Head, Department for Newborn Children, Children City Clinical Hospital No. 5
E. V. Shabaldina
Kemerovo State Medical University
Russian Federation
PhD, MD (Medicine), Associate Professor, Head, Department of Otolaryngology and Clinical Immunology, Kemerovo State Medical University
Russian Federation
PhD, MD (Medicine), Associate Professor, Head, Department of Otolaryngology and Clinical Immunology, Kemerovo State Medical University
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For citations:
Shabaldin A.V., Tsepokina A.V., Shmulevich S.A., Ponasenko A.V., Kryukov P.M., Shabaldina E.V. DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS. Medical Immunology (Russia). 2017;19(6):763-770. (In Russ.) https://doi.org/10.15789/1563-0625-2017-6-763-770
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