ХАРАКТЕРИСТИКА И РОЛЬ РАЗЛИЧНЫХ ПОПУЛЯЦИЙ МАКРОФАГОВ В ПАТОГЕНЕЗЕ ОСТРЫХ И ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЙ ЛЕГКИХ
https://doi.org/10.15789/1563-0625-2017-6-657-672
Аннотация
Макрофаги являются одной из самых многочисленных популяций клеток респираторного тракта, отличающейся способностью приобретать разнообразные фенотипы, в зависимости от сигналов микроокружения (классически активированные М1, альтернативно активированные М2). Есть все основания полагать, что различные популяции макрофагов принимают участие как в защите организма от инфекционных патогенов, так и в предотвращении неконтролируемого воспаления в тканях. Изменение фенотипов макрофагов в легких характерно для многих заболеваний респираторного тракта, включая бронхиальную астму, хроническую обструктивную болезнь легких, легочный фиброз и инфекционные заболевания. В данном литературном обзоре мы сфокусировались на биологии, происхождении и характеристике известных фенотипов макрофагов, а также представили современные данные об их роли в развитии хронических заболеваний легких – бронхиальной астмы и хронической обструктивной болезни легких, а также острых заболеваний бактериальной и вирусной природы.
Ключевые слова
Об авторах
А. А. Никонова
ФГБУ «ГНЦ Институт иммунологии» ФМБА России;
ФГБНУ «Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова»
Россия
Россия
к.б.н., заведующая лабораторией молекулярной биотехнологии ФГБНУ «Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова»; ФГБУ «ГНЦ Институт иммунологии» ФМБА России
115478, Россия, Москва, Каширское шоссе, 24/2
М. Р. Хаитов
ФГБУ «ГНЦ Институт иммунологии» ФМБА России
Россия
Россия
д.м.н., профессор, член-корреспондент РАН, исполняющий обязанности директора ФГБУ «ГНЦ Институт иммунологии» ФМБА России
115478, Россия, Москва, Каширское шоссе, 24/2
Р. М. Хаитов
ФГБУ «ГНЦ Институт иммунологии» ФМБА России
Россия
Россия
д.м.н., профессор, академик РАН, научный руководитель ФГБУ «ГНЦ Институт иммунологии» ФМБА России
115478, Россия, Москва, Каширское шоссе, 24/2
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Рецензия
Для цитирования:
Никонова А.А., Хаитов М.Р., Хаитов Р.М. ХАРАКТЕРИСТИКА И РОЛЬ РАЗЛИЧНЫХ ПОПУЛЯЦИЙ МАКРОФАГОВ В ПАТОГЕНЕЗЕ ОСТРЫХ И ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЙ ЛЕГКИХ. Медицинская иммунология. 2017;19(6):657-672. https://doi.org/10.15789/1563-0625-2017-6-657-672
For citation:
Nikonova A.A., Khaitov M.R., Khaitov R.M. CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES. Medical Immunology (Russia). 2017;19(6):657-672. (In Russ.) https://doi.org/10.15789/1563-0625-2017-6-657-672
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