РАЗРАБОТКА ВАКЦИН НА ОСНОВЕ АДЕНОВИРУСНЫХ ВЕКТОРОВ: ОБЗОР ЗАРУБЕЖНЫХ КЛИНИЧЕСКИХ ИССЛЕДОВАНИЙ (ЧАСТЬ 2)

В настоящее время для  многих инфекционных  заболеваний человека не  разработаны эффективные способы лечения и профилактики. Одним из  последних достижений биотехнологии является использование аденовирусных векторов, несущих иммунодоминантные антигены различных патогенов, в качестве генно-инженерных вакцин как профилактических, так и терапевтических. Использование генно-инженерных  технологий позволяет не  применять при  производстве вакцин живые вирусы и бактерии, сокращает время разработки и получения новых  вакцинных препаратов. Аденовирусные векторы естественным путем проникают в клетки человека, вызывая довольно длительный и значительный как  гуморальный, так и клеточный иммунный ответ.  Во второй части  обзора  мы  планируем привести сведения о проводимых в настоящее время за рубежом клинических испытаниях вакцин на  основе аденовирусных векторов против таких  инфекционных заболеваний, как грипп, малярия, геморрагическая лихорадка Эбола, туберкулез, гепатит и ряда других. Будут рассмотрены параметры отбора  добровольцев, схемы и дозы, используемые при вакцинации, приведены результаты завершенных экспериментов  и предварительные результаты незаконченных на  данный момент исследований.

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