REGULATORY T CELLS IN CHILDREN WITH ALLERGY
https://doi.org/10.15789/1563-0625-2008-2-3-159-166
Abstract
Abstract. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase of FOXP3 expression that may represent some mechanisms of their therapeutic effects. The amount of Treg’s gradually decrease with age in non-atopic children; they also decrease in atopic ones until 6 years, followed by their subsequent stabilization. Thus, a hypothesis is proposed, that the initial changes of Treg’s in case of allergy comprise a reduction in their functions, and, upon complete or partial compensation of this defect by increasing of cell amounts, a remission is initiated. However, in absence of compensation, acute attacks of allergic disorders are developed. (Med. Immunol., 2008, vol. 10, N 2-3, pp 159-166).
About the Authors
A. Donetskova
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
N. Sharova
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
M. Litvina
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
O. Burmenskaya
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
D. Trofimov
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
M. Yartsev
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
L. Alexeev
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
A. Yarilin
ГНЦ – Институт иммунологии ФМБА России, Москва
Russian Federation
Russian Federation
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Review
For citations:
Donetskova A., Sharova N., Litvina M., Burmenskaya O., Trofimov D., Yartsev M., Alexeev L., Yarilin A. REGULATORY T CELLS IN CHILDREN WITH ALLERGY. Medical Immunology (Russia). 2008;10(2-3):159-166. (In Russ.) https://doi.org/10.15789/1563-0625-2008-2-3-159-166
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