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Медицинская иммунология

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РОЛЬ МАКРОФАГОВ В ВОССТАНОВЛЕНИИ ПОВРЕЖДЕНИЙ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ: НОВЫЕ ВОЗМОЖНОСТИ В ЛЕЧЕНИИ НЕВРОЛОГИЧЕСКИХ РАССТРОЙСТВ

https://doi.org/10.15789/1563-0625-2017-1-7-18

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Аннотация

Смена существующих парадигм относительно регенеративного потенциала центральной нервной системы (ЦНС) и роли иммунных клеток в процессах восстановления поврежденной нервной ткани открывают новые перспективы лечения неврологических расстройств на основе иммуно-терапевтических подходов. Настоящий обзор посвящен анализу роли макрофагов в восстановлении повреждений в ЦНС и включает данные о функциональной гетерогенности клеток микроглии и макрофагов моноцитарного происхождения, путях рекрутирования моноцитов в ЦНС, взаимоотношении клеток микроглии и рекрутируемых макрофагов и балансе М1/М2-клеток при нейропатологии. Кроме того, в обзоре приводится экспериментальное обоснование участия макрофагов в восстановлении повреждений ЦНС и рассматриваются механизмы регенеративной активности макрофагов. Приведенные данные позволяют рассматривать макрофаги в качестве новой мишени терапевтических воздействий для подавления нейровоспалительной реакции и усиления репаративных процессов. Первые шаги в этой области свидетельствуют о перспективности применения моноцитов/ макрофагов или технологий М1→М2 переключения в лечении неврологических расстройств и обосновывают необходимость дальнейших исследований в данном направлении.

Об авторах

Е. Р. Черных
ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии»
Россия

д.м.н., профессор, член-корр. РАН, заведующая лабораторией клеточной иммунотерапии

630099, г. Новосибирск, ул. Ядринцевская, 14



Е. Я. Шевела
ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии»
Россия

д.м.н., ведущий научный сотрудник, лаборатория клеточной иммунотерапии,

г. Новосибирск



А. А. Останин
ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии»
Россия

д.м.н., профессор, главный научный сотрудник лаборатории клеточной иммунотерапии,

г. Новосибирск



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Черных Е.Р., Шевела Е.Я., Останин А.А. РОЛЬ МАКРОФАГОВ В ВОССТАНОВЛЕНИИ ПОВРЕЖДЕНИЙ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ: НОВЫЕ ВОЗМОЖНОСТИ В ЛЕЧЕНИИ НЕВРОЛОГИЧЕСКИХ РАССТРОЙСТВ. Медицинская иммунология. 2017;19(1):7-18. https://doi.org/10.15789/1563-0625-2017-1-7-18

For citation:


Chernykh E.R., Shevela E.Y., Ostanin A.A. THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS. Medical Immunology (Russia). 2017;19(1):7-18. (In Russ.) https://doi.org/10.15789/1563-0625-2017-1-7-18

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