РОЛЬ РАЗЛИЧНЫХ СУБПОПУЛЯЦИЙ CD4 + Т-ЛИМФОЦИТОВ ПРИ БЕРЕМЕННОСТИ

Д. И. Соколов; О. И. Степанова; С. А. Сельков

doi:10.15789/1563-0625-2016-6-521-536

РОЛЬ РАЗЛИЧНЫХ СУБПОПУЛЯЦИЙ CD4⁺Т-ЛИМФОЦИТОВ ПРИ БЕРЕМЕННОСТИ

Д. И. Соколов, О. И. Степанова, С. А. Сельков

https://doi.org/10.15789/1563-0625-2016-6-521-536

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Аннотация

Важную роль в формировании иммунологической толерантности при беременности играют Т-лимфоциты. В настоящем обзоре рассматривается характеристика Т-лимфоцитов децидуальной оболочки и плаценты, особенности их миграции и функциональной активности при беременности. В обзоре обсуждается роль субпопуляций Th1-, Th17-, Th2- и Treg-лимфоцитов в формировании плаценты и иммунорегуляции беременности, а также их взаимодействие с клетками децидуальной оболочки и трофобласта.

Ключевые слова

беременность, плацента, лимфоциты, трофобласт, децидуальная оболочка

Об авторах

Д. И. Соколов

ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им Д.О. Отта» Санкт-Петербург, Россия
Россия

д.б.н., заведующий лабораторией межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий

О. И. Степанова

к.б.н., старший научный сотрудник лаборатории межклеточных взаимодействий, отдел иммунологии и межклеточных взаимодействий

С. А. Сельков

д.м.н., профессор, руководитель отдела иммунологии и межклеточных взаимодействий

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Для цитирования:

Соколов Д.И., Степанова О.И., Сельков С.А. РОЛЬ РАЗЛИЧНЫХ СУБПОПУЛЯЦИЙ CD4⁺Т-ЛИМФОЦИТОВ ПРИ БЕРЕМЕННОСТИ. Медицинская иммунология. 2016;18(6):521-536. https://doi.org/10.15789/1563-0625-2016-6-521-536

For citation:

Sokolov D.I., Stepanova O.I., Selkov S.I. THE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4⁺Т LYMPHOCYTES DURING PREGNANCY. Medical Immunology (Russia). 2016;18(6):521-536. (In Russ.) https://doi.org/10.15789/1563-0625-2016-6-521-536

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РОЛЬ РАЗЛИЧНЫХ СУБПОПУЛЯЦИЙ CD4+Т-ЛИМФОЦИТОВ ПРИ БЕРЕМЕННОСТИ