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ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ АГОНИСТОВ И АНТАГОНИСТОВ ТОЛЛ-ПОДОБНЫХ РЕЦЕПТОРОВ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ

Аннотация

Разработчики антивирусных препаратов, обычно, фокусируются непосредственно на вирусах, как основных объектах для исследований.  Однако клеточные компоненты, участвующие в жизненном цикле вирусов или иммунном ответе на вирусные инфекции, становятся все более привлекательными мишенями, что открывает новые возможности для противовирусной терапии. Толл-подобные рецепторы (TLR) играют важную роль в активации, как врожденного, так и адаптивного иммунного ответа, в т.ч. на вирусные инфекции респираторного тракта. В данном обзоре мы рассмотрим TLR как мишень для разработки новых противовирусных препаратов, рассмотрим механизм запуска противовирусного ответа, посредством индукции интерферонов I типа, а также механизмы ухода вирусов от иммунного ответа. Также рассмотрим существующие соединения - агонисты и антагонисты TLR и обсудим вопросы безопасности их применения.

Об авторах

Александра Александровна Никонова
1. ФГБУ “ГНЦ Институт иммунологии” ФМБА России 2. ФГБНУ НИИВС им. И.И. Мечникова
Россия
к.б.н., зав. лабораторией молекулярной биотехнологии


Муса Рахимович Хаитов
ФГБУ “ГНЦ Институт иммунологии” ФМБА России
д.м.н., профессор, член-корреспондент РАН, директор ФГБУ “ГНЦ Институт иммунологии” ФМБА России


Рахим Мусаевич Хаитов
ФГБУ “ГНЦ Институт иммунологии” ФМБА России
д.м.н., профессор, академик РАН, научный руководитель ФГБУ “ГНЦ Институт иммунологии” ФМБА России


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Никонова А.А., Хаитов М.Р., Хаитов Р.М. ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ АГОНИСТОВ И АНТАГОНИСТОВ ТОЛЛ-ПОДОБНЫХ РЕЦЕПТОРОВ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ. Медицинская иммунология. 0;.

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Nikonova A.A., Khaitov M.R., Khaitov R.M. PROSPECTS OF TOLL-LIKE RECEPTOR AGONISTS AND ANTAGONISTS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS. Medical Immunology (Russia). 0;.

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