mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2015-6-567-572mimmun-964Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT COMMUNICATIONSГЕН РЕЦЕПТОРА ИНТЕРЛЕЙКИНА 28 АЛЬФА IL28RA И ПСОРИАЗ: АССОЦИАЦИЯ С ТЯЖЕСТЬЮ БОЛЕЗНИ И ВОЗРАСТОМ МАНИФЕСТАЦИИINTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSETГалимоваЭ. С.GalimovaE. S.

к.б.н., научный сотрудник лаборатории молекулярной генетики человека,Институт биохимии и генетики Уфимского научного центра Российской академии наук, г. Уфа, Россия 450054, Россия, г. Уфа, пр. Октября, 71. Тел./факс: 8 (3472) 235-60-88

PhD (Biology), Research Associate, Laboratory of Human Molecular Genetics, Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Russian Federation 450054, Russian Federation, Ufa, Oktyabrya av.,1. Phone/Fax: 7 (3472) 235-60-88

elya-4@yandex.ruХуснутдиноваЭ. К.KhusnutdinovaE. K.

д.б.н., профессор, заведующая лабораторией молекулярной генетики человека, Институт биохимии и генетики Уфимского научного центра Российской академии наук, г. Уфа, Россия

PhD, MD (Biology), Professor, Head, Laboratory of Human Molecular Genetics, Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Russian Federation

Институт биохимии и генетики Уфимского научного центра Российской академии наук, г. Уфа, РоссияРоссияInstitute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Russian FederationRussian Federation201514012016176567572Copyright © Галимова Э.С., Хуснутдинова Э.К., 20162016Галимова Э.С., Хуснутдинова Э.К.Galimova E.S., Khusnutdinova E.K.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/964

Молекулярные основы патогенеза псориаза, хронического воспалительного дераматоза, остаются неясными, но основные патоморфологические изменения кожи – нарушение дифференцировки и гиперпролиферация кератиноцитов, рост и расширение кровеносных сосудов и инфильтрация лейкоцитов дермы и эпидермиса – обусловлены действием различных цитокинов и хемокинов, продуцируемых иммунными клетками. Таким образом, целью данной работы является репликативный анализ ассоциаций полиморфного варианта rs4649203 гена IL28RA с риском развития псориаза. В работе использованы образцы ДНК 341 больных псориазом и 407 здоровых доноров. Генотипирование полиморфного локуса rs4649203 гена IL28RA было проведено методом полимеразной цепной реакции в режиме реального времени с использованием CFX 96™ Real-Time Cycler (BioRad). Настоящим исследованием установлено, что полиморфный вариант гена IL28RA играет важную роль как в патогенезе псориаза, так в клиническом течении и манифестации заболевания. Полученные результаты могут быть использованы для разработки персонифицированного подхода в тактике лечения пациентов.

Molecular basis still remains unclear for psoriasis, a chronic inflammatory skin disease. It biological features are presented by abnormal differentiation of epidermal keratinocytes, overgrowth and dilation of blood vessels, and leukocyte infiltration of dermal and epidermal skin layers. These events appear to be driven, mainly, by various cytokines and chemokines released by activated T cell populations. The aim of this replication study was to determine, whether the rs4649203 SNP of IL28RA gene is associated with susceptibility to psoriasis. A total of 341 patients with psoriasis and 407 matched healthy controls were enrolled to carry out a case control study. Genotyping was performed using a Real-Time PCR assay. Our preliminary data suggest that the polymorphism located in IL28RA gene, known to be related to inflammatory and immunity processes, showed an association with patients’ age at onset and the disease severity. The results of this study are promising, with respect to development of a personalized approach to psoriasis treatment.

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The authors declare that there are no conflicts of interest present.