mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2009-1-41-48mimmun-94Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESКОНЦЕНТРАЦИИ ПОДКЛАССОВ IgG У РЕЦИПИЕНТОВ АЛЛОГЕННОГО КОСТНОГО МОЗГАCONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTSКлимовичА. В.KlimovichA. V.aklimovit@gmail.comВан ЛинтМ. Т.Van LintM. T.aklimovit@gmail.comСамойловичМ. П.SamoilovichM. P.aklimovit@gmail.comАфанасьевБ. В.AfanasievB. V.aklimovit@gmail.comКлимовичВ. Б.KlimovichV. B.aklimovit@gmail.comГУЗ «Городская Клиническая больница № 31», Санкт-ПетербургRussian FederationЦентр трансплантации костного мозга Ospedale San-Martino, г. ГенуяItalyРоссийский научный центр радиологии и хирургических технологий, Санкт-ПетербургRussian Federation2009140720141114148Copyright © Климович А.В., Ван Линт М.Т., Самойлович М.П., Афанасьев Б.В., Климович В.Б., 20142014Климович А.В., Ван Линт М.Т., Самойлович М.П., Афанасьев Б.В., Климович В.Б.Klimovich A.V., Van Lint M.T., Samoilovich M.P., Afanasiev B.V., Klimovich V.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/94

A sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients. That was the main reason for therapeutic application of intravenous human immunoglobulins in allo-BM-recipients. In present study, multiple repeated measurements of different IgG subclasses were performed in blood serum of thirty-six patients at early terms after allogenic bone marrow transplantation period, along with analysis of individual clinical data. The study revealed several factors that show significant associations with IgG levels posttransplant. Moderate decrease in concentrations of IgG subclasses was registered after conditioning treatment carried out before the transplantation. Significantly decreased concentrations of IgG subclasses have been revealed during bleedings, diarrhea and glucocorticosteroid therapy. In general, however, no regular prolonged deficiency for total IgG subclasses was found in allogeneic bone marrow recipients during early posttransplant period.

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The authors declare that there are no conflicts of interest present.