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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2010-3-213-218</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-93</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ИММУНОЛОГИЧЕСКИЕ МЕТОДЫ В ОЦЕНКЕ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ ТРОМБОЦИТОВ У БОЛЬНЫХ С СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИ</article-title><trans-title-group xml:lang="en"><trans-title>IMMUNOLOGICAL METHODS FOR EVALUATION OF PLATELET FUNCTIONS IN THE PATIENTS  WITH CARDIOVASCULAR DISEASES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сироткина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sirotkina</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">olgasirotkina@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боганькова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogan’kova</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">olgasirotkina@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ласковец</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Laskovets</surname><given-names>A. B.</given-names></name></name-alternatives><email xlink:type="simple">olgasirotkina@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кухарчик</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuharchik</surname><given-names>G. A.</given-names></name></name-alternatives><email xlink:type="simple">olgasirotkina@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гайковая</surname><given-names>Л. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaykovaya</surname><given-names>L. B.</given-names></name></name-alternatives><email xlink:type="simple">olgasirotkina@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вавилова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vavilova</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">olgasirotkina@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Государственное образовательное учреждение высшего профессионального образования «Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова» Министерства здравоохранения и социального развития РФ &#13;
Учреждение Российской академии наук Петербургский институт ядерной физики им. Б.П. Константинова РАН</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Государственное образовательное учреждение высшего профессионального образования «Санкт-&#13;
Петербургская государственная медицинская академия им. И.И. Мечникова» Министерства здравоохранения и социального развития РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>14</day><month>07</month><year>2014</year></pub-date><volume>12</volume><issue>3</issue><fpage>213</fpage><lpage>218</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сироткина О.В., Боганькова Н.А., Ласковец А.Б., Кухарчик Г.А., Гайковая Л.Б., Вавилова Т.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Сироткина О.В., Боганькова Н.А., Ласковец А.Б., Кухарчик Г.А., Гайковая Л.Б., Вавилова Т.В.</copyright-holder><copyright-holder xml:lang="en">Sirotkina O.V., Bogan’kova N.A., Laskovets A.B., Kuharchik G.A., Gaykovaya L.B., Vavilova T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/93">https://www.mimmun.ru/mimmun/article/view/93</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>экспрессия Р-селектина</kwd><kwd>GP IIb-IIIa</kwd><kwd>АДФ-индуцированная агрегация тромбоцитов</kwd><kwd>проточная  цитометрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>P-selectin expression</kwd><kwd>GP IIb-IIIa</kwd><kwd>ADP-induced  platelet aggregation</kwd><kwd>flow cytometry</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Хайдуков С.В., Зурочка А.В. Вопросы современной проточной цитометрии. Клиническое применение. -Челябинск, 2008. -195 с.</mixed-citation><mixed-citation xml:lang="en">Хайдуков С.В., Зурочка А.В. Вопросы современной проточной цитометрии. Клиническое применение. -Челябинск, 2008. -195 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Шитикова А.С. Тромбоцитарный гемостаз. -СПб.: Издательство СПб ГМУ, 2000. -227 с.</mixed-citation><mixed-citation xml:lang="en">Шитикова А.С. Тромбоцитарный гемостаз. -СПб.: Издательство СПб ГМУ, 2000. -227 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Barsky A.A., Arora R.R. Clopidogrel resistance: myth or reality?//J. Cardiovasc. Pharmacol. Therapeut. -2006. -Vol. 11, N 1. -P. 47-53.</mixed-citation><mixed-citation xml:lang="en">Barsky A.A., Arora R.R. Clopidogrel resistance: myth or reality?//J. Cardiovasc. Pharmacol. Therapeut. -2006. -Vol. 11, N 1. -P. 47-53.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Braun O.O., Amisten S., Wihlborg A.-K., Hunting K., Nillson D., Erlinge D. Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y1 and the P2Y12 receptor and is correlated with protein expression of P2Y12//Purinergic Signalling. -2007. -Vol. 3. -P. 195-201.</mixed-citation><mixed-citation xml:lang="en">Braun O.O., Amisten S., Wihlborg A.-K., Hunting K., Nillson D., Erlinge D. Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y1 and the P2Y12 receptor and is correlated with protein expression of P2Y12//Purinergic Signalling. -2007. -Vol. 3. -P. 195-201.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Braun O.O., Johnell M., Varenhorst C., James S., Brandt J.T., Jakubowski J.A., Winters K.J., Wallentin L., Erlinge D., Siegbahn A. Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease//Thromb. Haemost. -2008. -Vol. 100, N 4. -P. 626-633.</mixed-citation><mixed-citation xml:lang="en">Braun O.O., Johnell M., Varenhorst C., James S., Brandt J.T., Jakubowski J.A., Winters K.J., Wallentin L., Erlinge D., Siegbahn A. Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease//Thromb. Haemost. -2008. -Vol. 100, N 4. -P. 626-633.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cattaneo M. Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection//J. Thromb. Haemost. -2007. -Vol. 5, N 1. -P. 230-237.</mixed-citation><mixed-citation xml:lang="en">Cattaneo M. Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection//J. Thromb. Haemost. -2007. -Vol. 5, N 1. -P. 230-237.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Еnjeti A.K., Lincz L.F., Seldon M. Detection and measurement of microparticles: an evolving research tool for vascular biology//Semin Thromb Hemost. -2007. -Vol. 33. -N 8. -P. 771-779.</mixed-citation><mixed-citation xml:lang="en">Еnjeti A.K., Lincz L.F., Seldon M. Detection and measurement of microparticles: an evolving research tool for vascular biology//Semin Thromb Hemost. -2007. -Vol. 33. -N 8. -P. 771-779.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ferguson A., Dokainish H., Lakkis N. Aspirin and clopidogrel response variability//Tex. Heart. Inst. J. -2008. -Vol. 35, N 3. -P. 313-320.</mixed-citation><mixed-citation xml:lang="en">Ferguson A., Dokainish H., Lakkis N. Aspirin and clopidogrel response variability//Tex. Heart. Inst. J. -2008. -Vol. 35, N 3. -P. 313-320.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fitzgerald D.J., Maree A. Aspirin and clopidogrel resistance//Hematology. Am. Soc. Hematol. Educ. Program. -2007. -P. 114-120.</mixed-citation><mixed-citation xml:lang="en">Fitzgerald D.J., Maree A. Aspirin and clopidogrel resistance//Hematology. Am. Soc. Hematol. Educ. Program. -2007. -P. 114-120.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gurbel P.A., Tantry U.S. Clopidogrel resistance?//Thromb. Research. -2007. -Vol. 120. -P. 311-321.</mixed-citation><mixed-citation xml:lang="en">Gurbel P.A., Tantry U.S. Clopidogrel resistance?//Thromb. Research. -2007. -Vol. 120. -P. 311-321.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hayward C.P.M. Advances in understanding «high on-treatment platelet reactivity»//Thromb. Haemost. -2009. -Vol. 102. -P. 799-800.</mixed-citation><mixed-citation xml:lang="en">Hayward C.P.M. Advances in understanding «high on-treatment platelet reactivity»//Thromb. Haemost. -2009. -Vol. 102. -P. 799-800.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">ISLH 2008, Sydney, Coagulation/Haemostasis Workshop.</mixed-citation><mixed-citation xml:lang="en">ISLH 2008, Sydney, Coagulation/Haemostasis Workshop.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Koenig W. Haemostatic risk factors for cardiovascular diseases//Eur. Heart. J. -1998. -Vol. 19. -C. 39-43.</mixed-citation><mixed-citation xml:lang="en">Koenig W. Haemostatic risk factors for cardiovascular diseases//Eur. Heart. J. -1998. -Vol. 19. -C. 39-43.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Oestreich J., Smyth S., Campbell C. Platelet function analisis: at the edge of meaning//Thromb. Haemost. -2009. -Vol. 101. -P. 217-219.</mixed-citation><mixed-citation xml:lang="en">Oestreich J., Smyth S., Campbell C. Platelet function analisis: at the edge of meaning//Thromb. Haemost. -2009. -Vol. 101. -P. 217-219.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shantsila E., Lip G.Y.H. The role of monocytes in thrombotic disorders//Thromb. Haemost. -2009. -Vol. 102. -P. 916-924.</mixed-citation><mixed-citation xml:lang="en">Shantsila E., Lip G.Y.H. The role of monocytes in thrombotic disorders//Thromb. Haemost. -2009. -Vol. 102. -P. 916-924.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Storey R., JudgeH., Heptinstall S. Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin//Thromb. Haemost. -2002. -Vol. 88, N 3. -P. 488-494.</mixed-citation><mixed-citation xml:lang="en">Storey R., JudgeH., Heptinstall S. Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin//Thromb. Haemost. -2002. -Vol. 88, N 3. -P. 488-494.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Szczeklik A., Musial J., Undas A., Sanak M. Aspirin resistance//J. Thromb. Haemost. -2005. -Vol. 3. -P. 1655-1662.</mixed-citation><mixed-citation xml:lang="en">Szczeklik A., Musial J., Undas A., Sanak M. Aspirin resistance//J. Thromb. Haemost. -2005. -Vol. 3. -P. 1655-1662.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
