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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2010-3-199-206</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-89</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ПРОТИВООПУХОЛЕВАЯ АКТИВНОСТЬ ДЕНДРИТНЫХ КЛЕТОК ЗДОРОВЫХ ДОНОРОВ И БОЛЬНЫХ С ОПУХОЛЯМИ ГОЛОВНОГО МОЗГА</article-title><trans-title-group xml:lang="en"><trans-title>ANTI-TUMOR ACTIVITY OF DENDRITIC CELLS IN HEALTHY DONORS AND PATIENTS  WITH BRAIN TUMORS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черных</surname><given-names>Е. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernykh</surname><given-names>E. R.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леплина</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Leplina</surname><given-names>O. Yu.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тыринова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyrinova</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhonova</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ступак</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stupak</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мишинов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mishinov</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пендюрин</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pendyurin</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Останин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ostanin</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">ct_lab@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ клинической иммунологии СО РАМН, г. Новосибирск</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГУ НИИ травматологии и ортопедии Росмедтехнологий, г. Новосибирск</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>14</day><month>07</month><year>2014</year></pub-date><volume>12</volume><issue>3</issue><fpage>199</fpage><lpage>206</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черных Е.Р., Леплина О.Ю., Тыринова Т.В., Тихонова М.А., Ступак В.В., Мишинов С.В., Пендюрин И.В., Останин А.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Черных Е.Р., Леплина О.Ю., Тыринова Т.В., Тихонова М.А., Ступак В.В., Мишинов С.В., Пендюрин И.В., Останин А.А.</copyright-holder><copyright-holder xml:lang="en">Chernykh E.R., Leplina O.Y., Tyrinova T.V., Tikhonova M.A., Stupak V.V., Mishinov S.V., Pendyurin I.V., Ostanin A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/89">https://www.mimmun.ru/mimmun/article/view/89</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>дендритные клетки</kwd><kwd>цитотоксическая/статическая активность</kwd><kwd>опухолевые клеточные линии</kwd><kwd>опухоли  головного мозга.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dendritic cells</kwd><kwd>cytotoxic/cytostatic activity</kwd><kwd>tumor cell  lines</kwd><kwd>brain tumors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Черных Е.Р., Леплина О.Ю., Ступак В.В., Пендюрин И.В., Никонов С.Д., Тихонова М.А., Останин А.А. Клеточные технологии в лечении злокачественных глиом головного мозга//Клеточные технологии. Теоретические и прикладные аспекты. -Новосибирск: Наука, 2009. -С. 240-276.</mixed-citation><mixed-citation xml:lang="en">Черных Е.Р., Леплина О.Ю., Ступак В.В., Пендюрин И.В., Никонов С.Д., Тихонова М.А., Останин А.А. Клеточные технологии в лечении злокачественных глиом головного мозга//Клеточные технологии. Теоретические и прикладные аспекты. -Новосибирск: Наука, 2009. -С. 240-276.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y., Pulendran B., Palucka K. Immunobiology of dendritic cells//Annu Rev Immunol. -2000. -Vol. 18. -P. 767-811.</mixed-citation><mixed-citation xml:lang="en">Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y., Pulendran B., Palucka K. Immunobiology of dendritic cells//Annu Rev Immunol. -2000. -Vol. 18. -P. 767-811.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Becker Y. Dendritic cell activity against primary tumors: an overview//In Vivo. -1993. -Vol. 7. -P. 187-191.</mixed-citation><mixed-citation xml:lang="en">Becker Y. Dendritic cell activity against primary tumors: an overview//In Vivo. -1993. -Vol. 7. -P. 187-191.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Chaperot L., Blum A., Manches O., Lui G., Angel J., Molens J-P., Plumas J. Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells//J. Immunol. -2006. -Vol. 176. -P. 248-255.</mixed-citation><mixed-citation xml:lang="en">Chaperot L., Blum A., Manches O., Lui G., Angel J., Molens J-P., Plumas J. Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells//J. Immunol. -2006. -Vol. 176. -P. 248-255.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chapoval A.I., Tamada K., Chen L. In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells//Blood. -2000. -Vol. 95. -P. 2346-2351.</mixed-citation><mixed-citation xml:lang="en">Chapoval A.I., Tamada K., Chen L. In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells//Blood. -2000. -Vol. 95. -P. 2346-2351.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chauvin C., Josien R. Dendritic cells as killers: mechanistic aspects and potential roles// J. Immunol. -2008. -Vol. 18. -P. 11-16.</mixed-citation><mixed-citation xml:lang="en">Chauvin C., Josien R. Dendritic cells as killers: mechanistic aspects and potential roles// J. Immunol. -2008. -Vol. 18. -P. 11-16.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Della Bella S., Nicola S., Riva A., Biasin M., Clerici M., Villa M.L. Functional repertoire of dendritic cells generated in granulocyte macrophage-colony stimulating factor and interferon-α//J. Leuk Biol. -2004. -Vol. 75. -P. 106-116.</mixed-citation><mixed-citation xml:lang="en">Della Bella S., Nicola S., Riva A., Biasin M., Clerici M., Villa M.L. Functional repertoire of dendritic cells generated in granulocyte macrophage-colony stimulating factor and interferon-α//J. Leuk Biol. -2004. -Vol. 75. -P. 106-116.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ehtesham M.P., Kabos M.A., Gutierrez K., Samoto K.L., Black J., Yu S. Intratumoral dendritic cell vaccination elicits potent tumoricidal immunity against malignant glioma in rats//J. Immunother. -2003. -Vol. 26. -P. 107-116.</mixed-citation><mixed-citation xml:lang="en">Ehtesham M.P., Kabos M.A., Gutierrez K., Samoto K.L., Black J., Yu S. Intratumoral dendritic cell vaccination elicits potent tumoricidal immunity against malignant glioma in rats//J. Immunother. -2003. -Vol. 26. -P. 107-116.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fanger N.A., Maliszewski C.R., Schooley K., Griffith T.S. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)//J. Exp. Med. -1999. -Vol. 190. -P. 1155-1164.</mixed-citation><mixed-citation xml:lang="en">Fanger N.A., Maliszewski C.R., Schooley K., Griffith T.S. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)//J. Exp. Med. -1999. -Vol. 190. -P. 1155-1164.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Jun S., Ikeda K., Maeda Y., Shinagawa K., Ohtsuka A., Yamamura H., Tanimoto M. Identification of CD123+ myeloid dendritic cells as anearly-stage immature subset with strong tumoristatic potential//Cancer Letters. -2008. -Vol. 270. -P. 19-29.</mixed-citation><mixed-citation xml:lang="en">Jun S., Ikeda K., Maeda Y., Shinagawa K., Ohtsuka A., Yamamura H., Tanimoto M. Identification of CD123+ myeloid dendritic cells as anearly-stage immature subset with strong tumoristatic potential//Cancer Letters. -2008. -Vol. 270. -P. 19-29.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Korthals M., Safaian N., Kronenwett R., Maihfer D., Schott M., Papewalis C., Blanco E.D., Winter M., Czibere A., Haas R., Kobbe G., Fenk R. Monocyte derived dendritic cells generated by IFNα acquire mature dendritic and natural killer cell properties as shown by gene expression analysis// J. Translational Med. -2007. -Vol. 5. -P. 46-57.</mixed-citation><mixed-citation xml:lang="en">Korthals M., Safaian N., Kronenwett R., Maihfer D., Schott M., Papewalis C., Blanco E.D., Winter M., Czibere A., Haas R., Kobbe G., Fenk R. Monocyte derived dendritic cells generated by IFNα acquire mature dendritic and natural killer cell properties as shown by gene expression analysis// J. Translational Med. -2007. -Vol. 5. -P. 46-57.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Larmonier K., Fraszczak J., Lakomy D., Bonnotte B., Katsanis E. Killer dendritic cells and their potential for cancer immunotherapy//Cancer Immunol &amp; Immunother. -2009. -Vol. 59. -P. 1-11.</mixed-citation><mixed-citation xml:lang="en">Larmonier K., Fraszczak J., Lakomy D., Bonnotte B., Katsanis E. Killer dendritic cells and their potential for cancer immunotherapy//Cancer Immunol &amp; Immunother. -2009. -Vol. 59. -P. 1-11.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Liu S., Yu Y., Zhang M., Wang W., Cao X. The involvement of TNF-alpha-related apoptosis inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells// J. Immunol. -2001. -Vol. 166. -P. 5407-5415.</mixed-citation><mixed-citation xml:lang="en">Liu S., Yu Y., Zhang M., Wang W., Cao X. The involvement of TNF-alpha-related apoptosis inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells// J. Immunol. -2001. -Vol. 166. -P. 5407-5415.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Manna P.P., Mohanakumar T. Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro//J. Leuk Biol. -2002. -Vol. 72. -P. 312-320.</mixed-citation><mixed-citation xml:lang="en">Manna P.P., Mohanakumar T. Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro//J. Leuk Biol. -2002. -Vol. 72. -P. 312-320.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Melief C.J. Cancer immunotherapy by dendritic cells//Immunity. -2008. -Vol. 29. -P. 372-383.</mixed-citation><mixed-citation xml:lang="en">Melief C.J. Cancer immunotherapy by dendritic cells//Immunity. -2008. -Vol. 29. -P. 372-383.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Santini S., Pucchini T., Lapenta C., Parlato S., Logozzi M., Belardelli F. A new type 1 IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells//Stem cells. -2003. -Vol. 21. -P. 357-362.</mixed-citation><mixed-citation xml:lang="en">Santini S., Pucchini T., Lapenta C., Parlato S., Logozzi M., Belardelli F. A new type 1 IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells//Stem cells. -2003. -Vol. 21. -P. 357-362.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Shin J.Y., Lee C.D. Kang J.S., Chung E., Lee Y., Seo S.Y., Lee S.Y., Baek S.Y., Kim B.S., Kim J.B., Yoon S. Anti-tumor effect of intratumoral administration of dendritic cell combination with vincristine chemotherapy in a murine fibrosarcoma model//Histol. Histopathol. -2003. -Vol. 18. -P. 435-447.</mixed-citation><mixed-citation xml:lang="en">Shin J.Y., Lee C.D. Kang J.S., Chung E., Lee Y., Seo S.Y., Lee S.Y., Baek S.Y., Kim B.S., Kim J.B., Yoon S. Anti-tumor effect of intratumoral administration of dendritic cell combination with vincristine chemotherapy in a murine fibrosarcoma model//Histol. Histopathol. -2003. -Vol. 18. -P. 435-447.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tong Y., Song W., Crystal R.G. Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors//Cancer Res. -2001. -Vol. 61. -P. 7530-7535.</mixed-citation><mixed-citation xml:lang="en">Tong Y., Song W., Crystal R.G. Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors//Cancer Res. -2001. -Vol. 61. -P. 7530-7535.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Vanderheyde N., Vandenabeele P., Goldman M., Willems F. Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells//Immunol Lett. -2004. -Vol. 91. -P. 99-101.</mixed-citation><mixed-citation xml:lang="en">Vanderheyde N., Vandenabeele P., Goldman M., Willems F. Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells//Immunol Lett. -2004. -Vol. 91. -P. 99-101.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Vidalain P.O., Azocar O., Yagita H., Rabourdin-Combe C., Servet-Delprat C. Cytotoxic activity of human dendritic cells is differentially regulated by double-stranded RNA and CD40 ligand// J. Immunol. -2001. -Vol. 167, N 7. -P. 3765-3772.</mixed-citation><mixed-citation xml:lang="en">Vidalain P.O., Azocar O., Yagita H., Rabourdin-Combe C., Servet-Delprat C. Cytotoxic activity of human dendritic cells is differentially regulated by double-stranded RNA and CD40 ligand// J. Immunol. -2001. -Vol. 167, N 7. -P. 3765-3772.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wang M., Shi J., Wan Y., Li J., Yuan Y. A subset of myeloid dendritic cells derived from peripheral blood monocytes represented a predominant subset characterized by their potential tumor-inhibiting activity//In Vitro Cell. Dev. Biol.-Animal. -2009. -Vol. 45. -P. 398-404.</mixed-citation><mixed-citation xml:lang="en">Wang M., Shi J., Wan Y., Li J., Yuan Y. A subset of myeloid dendritic cells derived from peripheral blood monocytes represented a predominant subset characterized by their potential tumor-inhibiting activity//In Vitro Cell. Dev. Biol.-Animal. -2009. -Vol. 45. -P. 398-404.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Wesa A.K., Storkus W.J. Killer dendritic cells: mechanisms of action and therapeutic implications for cancer//Cell Death Differ. -2008. -Vol. 15. -P. 51-57.</mixed-citation><mixed-citation xml:lang="en">Wesa A.K., Storkus W.J. Killer dendritic cells: mechanisms of action and therapeutic implications for cancer//Cell Death Differ. -2008. -Vol. 15. -P. 51-57.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
