References

mimmun

Медицинская иммунология

Medical Immunology (Russia)

1563-06252313-741X

SPb RAACI

10.15789/1563-0625-2015-3-203-210

mimmun-884

Research Article

ОБЗОРЫ

REVIEWS

РЕВМАТОИДНЫЙ АРТРИТ: ЛАБОРАТОРНЫЕ МОДЕЛИ ЗАБОЛЕВАНИЯ

RHEUMATOID ARTHRITIS: LABORATORY MODELS OF THE DISEASE

Орловская

И. А.

Orlovskaya

I. A.

Доктор медицинских наук, профессор, заведующая лабораторией иммунобиологии стволовой клетки ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии», г. Новосибирск.

Адрес для переписки: Орловская Ирина Анатольевна ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии» 630099, Россия, г. Новосибирск, ул. Ядринцевская, 14. Тел.: 8 (913) 748-60-99. E-mail:irorl@mail.ru

PhD, MD (Medicine), Professor, Head, Laboratory of Stem Cell Immunobiology,

Address for correspondence: Orlovskaya Irina Anatolievna Research Institute of Basic and Clinical Immunology,630099, Russian Federation, Novosibirsk, Yadrintsevskaya str., 14. Phone: 7 (913) 748-60-99. E-mail:irorl@mail.ru

irorl@mail.ru

Цырендоржиев

Д. Д.

Tsyrendorzhiev

D. D.

Доктор медицинских наук, профессор, ведущий научный сотрудник ФГБНУ «Научноисследовательский институт фундаментальной и клинической иммунологии», г. Новосибирск

irorl@mail.ru

Щелкунов

С. Н.

Shchelkunov

S. N.

Доктор биологических наук, профессор, заведующий отделом геномных исследований и разработки методов ДНК-диагностики поксвирусов ФГУН ГНЦ ВБ «Вектор» Роспотребнадзора, п. Кольцово, Новосибирская область

irorl@mail.ru

Научно-исследовательский институт фундаментальной и клинической иммунологии, г. НовосибирскРоссияResearch Institute of Basic and Clinical Immunology, NovosibirskRussian Federation

«Вектор», п. Кольцово, Новосибирская область,РоссияState Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk regionRussian Federation

2015

30062015

173203210

2015

Орловская И.А., Цырендоржиев Д.Д., Щелкунов С.Н.

Orlovskaya I.A., Tsyrendorzhiev D.D., Shchelkunov S.N.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.mimmun.ru/mimmun/article/view/884

Эффективным подходом к исследованию ревматоидного артрита (РА) является создание и использование моделей животных. Экспериментальное изучение различных аспектов формирования и течения РА, включая ранний РА, позволяют приблизиться к пониманию этиопатогенетических механизмов заболевания человека. В обзоре рассматриваются известные в настоящее время модели заболевания. Использование этих моделей для тестирования потенциальных терапевтических препаратов поможет прогнозировать их эффективность

The establishment and application of animal models represent effective tools for research in rheumatoid arthritis (RA) pathogenesis. Animal models that replicate various mechanisms reflecting all aspects of RA, including early RA pathology, have provided important insights into studying etiology and pathogenetic mechanisms of RA in humans. This review article was compiled in order to give an introduction to the current state of RA models. Application of these experimental disorders for testing potential therapeutic approaches will help to make better predictions for drug efficiency in human RA

: ревматоидный артритмоделипатогенезэтиологияживотныеиммунология

rheumatoid arthritisexperimental modelspathogenesisetiologyanimalsimmunology

Российский научный фонд

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The authors declare that there are no conflicts of interest present.