mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2013-2-119-130mimmun-79Research ArticleОБЗОРЫREVIEWSЭНДОКАННАБИНОИДЫ И ЭЙКОЗАНОИДЫ: БИОСИНТЕЗ, МЕХАНИЗМЫ ИХ ВЗАИМОСВЯЗИ, РОЛЬ В ИММУННЫХ ПРОЦЕССАХENDOCANNABINOIDS AND EICOSAMOIDS: BIOSYNTHESIS AND INTERACTIONS WITH IMMUNE RESPONSEКараманЮ. К.KaramanYu. K.

к.б.н., cтарший научный сотрудник лаборатории биомедицинских исследований

Senior Research Associate

karaman@inbox.ruЛобановаЕ. Г.LobanovaE. G.

к.м.н., cтарший научный сотрудник лаборатории биомедицинских исследований

Senior Research Associate

karaman@inbox.ruВладивостокский филиал ФГБУ «Дальневосточный научный центр физиологии и патологии дыхания» СО РАМН – НИИ медицинской климатологии и восстановительного лечения, г. ВладивостокРоссияFederal State Budget Institution «Far Eastern Scientific Centre of Physiology and Pathology of Respiration», Vladivostok Branch Siberian Branch of Russian Academy of Medical Sciences – Research Institute of Medical Climatology and Rehabilitation Treatment, VladivostokRussian Federation201314072014152119130Copyright © Караман Ю.К., Лобанова Е.Г., 20142014Караман Ю.К., Лобанова Е.Г.Karaman Y.K., Lobanova E.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/79

Обзор посвящен современным представлениям о метаболитах арахидоновой кислоты – эндоканнабиноидам и эйкозаноидам, путях их биосинтеза, механизмах взаимодействия и роли в иммунных процессах. Приводятся новые данные литературы и результаты собственных исследований о перекрестности ферментативных путей биосинтеза эндоканнабиноидов и эйкозаноидов; влиянии синтетических лигандов каннабиноидных рецепторов на активность продукции провоспалительных цитокинов, эйкозаноидов; взаимосвязи между реактивностью иммунной системы и  уровнем экспрессии эндоканнабиноидных рецепторов.

The review is dedicated to modern concepts of arachidonic acid metabolites, i.e., endocannabinoids and eicosanoids, their biosynthetic pathways, cross-talk mechanisms and participation in immune response. New information from literature and own results include data concerning overlapping enzymatic pathways controlling biosynthesis of endocannabinoids and eicosanoids. Impact of synthetic cannabinoid receptor ligands upon production rates of proinflammatory cytokines and eicosanoids is discussed, as like as relationships among immune system reactivity and expression levels of cannabinoid receptors.

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The authors declare that there are no conflicts of interest present.