mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2014-5-409-416mimmun-726Research ArticleОБЗОРЫREVIEWSРОЛЬ Т-РЕГУЛЯТОРНЫХ КЛЕТОК (Тreg) В ИММУНОМОДУЛЯЦИИ, АССОЦИИРОВАННОЙ С ТРАНСФУЗИЯМИ ГЕМОКОМПОНЕНТОВ (ОБЗОР ЛИТЕРАТУРЫ)ROLE OF T REGULATORY CELLS (Тreg) IN TRANSFUSION-ASSOCIATED IMMUNOMODULATION (REVIEW)ГлазановаТ. В.GlazanovaT. V.

д.м.н., главный научный сотрудник лаборатории иммуногематологии ФГБУ «РосНИИГТ ФМБА» России191024, Россия, Санкт-Петербург, ул. 2-я Советская, 16. Тел.: 8 (812) 717-08-90

PhD, MD, Principal Research Associate, Laboratory of Immunohematology, Russian Research Institute of Hematologyand Transfusiology, Russian Medical and Biological Agency191024, Russian Federation, St. Petersburg, 2nd Sovetskaya str., 16. Phone: 7 (812) 717-08-90.

tatyana-glazanova@yandex.ruРозановаО. Е.RozanovaO. E.

д.б.н., ведущий научный сотрудник лаборатории иммуногематологии ФГБУ «РосНИИГТ ФМБА» России, Санкт-Петербург, Россия

PhD, MD (Biology), Leading Research Associate, Laboratory of Immunohematology, Russian Research Institute of Hematology and Transfusiology, Russian Medical and Biological Agency, St. Petersburg, Russian Federation

БубноваЛ. Н.BubnovaL. N.

д.м.н., профессор, руководитель лаборатории иммуногематологии ФГБУ «РосНИИГТ ФМБА» России, Санкт-Петербург, Россия

PhD, MD (Medicine), Professor, Head, Laboratory of Immunohematology, Russian Research Institute of Hematology and Transfusiology, Russian Medical and Biological Agency, St. Petersburg, Russian Federation

ФГБУ «Российский научно-исследовательский институт гематологии и трансфузиологии федерального медико-биологического агентства», Санкт-Петербург, РоссияРоссияRussian Research Institute of Hematology and Transfusiology, Russian Medical and Biological Agency, St. Petersburg, Russian FederationRussian Federation201422112014165409416Copyright © Глазанова Т.В., Розанова О.Е., Бубнова Л.Н., 20142014Глазанова Т.В., Розанова О.Е., Бубнова Л.Н.Glazanova T.V., Rozanova O.E., Bubnova L.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/726

В обзорной статье приведены данные о воздействии трансфузий гемокомпонентов на иммунную систему реципиентов, об эффектах ассоциированной с гемотрансфузиями иммуномодуляции. Дано представление о Т-регуляторных лимфоцитах, их роли в развитии толерантности к собственным антигенам и снижении противоопухолевого и противоинфекционного иммунного ответа, и их вкладе в развитие ассоциированной с трансфузиями гемокомпонентов иммуномодуляции.

In this review article, we present current clinical data about the effects of transfused hemocomponents upon immune system of the recipients, and about transfusion-related immunomodulation, with emphasis on the role of T-regulatory (Treg) cells in these events. The article describes a role of Treg’s in development of tolerance to self-antigens, in decrease of anti-neoplastic and anti-infection immune response, and their proposed role in transfusion-related immunomodulatory effects.

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The authors declare that there are no conflicts of interest present.