mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2014-3-295-300mimmun-696Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT COMMUNICATIONSСРАВНИТЕЛЬНАЯ ОЦЕНКА ТЕЧЕНИЯ ХРОНИЧЕСКОГО РЕЦИДИВИРУЮЩЕГО ФУРУНКУЛЕЗА И ФАГОЦИТАРНОГО ЗВЕНА ИММУНИТЕТА В ГРУППАХ БОЛЬНЫХ С РАЗЛИЧНЫМ УРОВНЕМ СЫВОРОТОЧНОГО ИММУНОГЛОБУЛИНА ЕCOMPARATIVE EVALUATION OF CHRONIC RECURRENT FURUNCULOSIS AND PHAGOCYTIC COMPONENT OF IMMUNITY AMONG PATIENTS DIFFERING IN IgE LEVELSДружининаТ. А.DruzhininaT. A.

к.б.н., старший научный сотрудник, ГБОУ ДПО «Пензенский институт усовершенствования врачей» Минздрава России

PhD (Biology), Senior Research Associate, Penza Institute of Postgraduate Education, Russian Ministry of Health Care

DrugininaM1992@mail.ruАлексееваН. Ю.AlekseevaN. Yu.

к.м.н., доцент кафедры аллергологии и иммунологии ГБОУ ДПО «Пензенский институт усовершенствования врачей» Минздрава России

PhD (Medicine), Assistant Professor, Allergology and Immunology Department, Penza Institute of Postgraduate Education, Russian Ministry of Health Care

ГБОУ ДПО «Пензенский институт усовершенствования врачей» Минздрава России, г. ПензаРоссияPenza Institute of Postgraduate Education, Russian Ministry of Health Care, PenzaRussian Federation201401082014163295300Copyright © Дружинина Т.А., Алексеева Н.Ю., 20142014Дружинина Т.А., Алексеева Н.Ю.Druzhinina T.A., Alekseeva N.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/696

Цель работы состояла в сравнительной оценке тяжести течения и основных показателей иммунного статуса у больных хроническим рецидивирующим фурункулезом (ХРФ) с различным уровнем сывороточного иммуноглобулина Е. В группе больных с повышенным уровнем IgE, по сравнению с группой больных с нормальными значениями указанного иммуноглобулина, выявлено статистически значимое более тяжелое течение заболевания, характеризующееся непрерывно рецидивирующим характером с множественными фурункулами и слабой воспалительной реакцией организма. В то же время у больных этой группы статистически реже развивались дополнительные глубокие гнойно-воспалительные заболевания кожных покровов. Сравнительная оценка основных эффекторных звеньев защиты от пиогенной инфекции позволила установить статистически значимое снижение индуцированной хемилюминесценции цельной гепаринизированной крови (р < 0,05) в группе больных с повышенными значениями иммуноглобулина Е, что может служить одной из причин более тяжелого течения ХРФ у данной категории больных.

The aim of this work was to compare clinical features of severity and some basic indicators of immune state in the patients with chronic recurrent furunculosis (CRF), differing in levels of serum immunoglobulin E (IgE). In cases with increased IgE levels, the clinical course proved to be more severe, as characterized by persistent recurrence of infection, with multiple lesions and weak inflammatory reaction, as compared with patients with normal IgE levels. Meanwhile, additional purulent skin lesions were less common among patients from this group. Comparative evaluation of basic anti-pyogenic defense effects allowed us to show a significant decrease of induced chemiluminescence of whole heparinized blood (p < 0.05) in patients with increased IgE levels, thus regarding it as a potential factor of more severe CRF clinical course in this cohort of patients.

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The authors declare that there are no conflicts of interest present.