mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2014-3-289-294mimmun-695Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT COMMUNICATIONSИЗМЕНЕНИЯ ИММУНОРЕГУЛЯТОРНЫХ ПЕПТИДОВ ПРИ ХИРУРГИЧЕСКОМ ЛЕЧЕНИИ РАКА ЖЕЛУДКАCHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCERМатвееваЛ. В.MatveevaL. V.

к.м.н., доцент кафедры иммунологии, микробиологии и вирусологии медицинского института ФГБОУ ВПО «Мордовский государственный университет им. Н.П. Огарёва»

PhD (Medicine), Associate Professor, Department of Immunology and Virology, Medical Institute, N.P. Ogarev Mordovsky State University

MatveevaLjubov1@mail.ruФГБОУ ВПО «Мордовский государственный университет им. Н.П. Огарёва», г. СаранскРоссияN.P. Ogarev Mordovsky State University, SaranskRussian Federation201401082014163289294Copyright © Матвеева Л.В., 20142014Матвеева Л.В.Matveeva L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/695

Проведено комплексное обследование 20 больных раком желудка на II стадии опухолевого процесса до и после хирургического лечения и 30 клинически здоровых добровольцев при получении информированного согласия. У больных раком желудка в сыворотке крови были выявлены изменения иммунорегуляторных пептидов, взаимосвязанные с гистологическим вариантом опухоли. Наибольшие предоперационные количества интерлейкина (IL)-1β, IL-2, IL-4, IL-10 определялись при высокодифференцированной аденокарциноме, IL-17, интерферона (IFN)-γ – при низкодифференцированной; уровень туморнекротизирующего фактора (TNF)-α не зависел от гистологического типа опухоли. После хирургического лечения сывороточные концентрации IL-1β, IL-2, IL-10 увеличивались при снижении количества IL-4, IL-17, IFNγ, TNFα. После лечения рака желудка развития гнойно-септических осложнений у пациентов в период наблюдения не отмечалось. Полученные результаты указывают на целесообразность определения цитокинового профиля у больных раком желудка на фоне лечения с проекцией на гистологический вариант опухоли для прогнозирования течения послеоперационного периода.

A complex clinical study included twenty patients with gastric cancer (tumor stage II) before and after surgical treatment, and 30 healthy volunteers, under appropriate informed consent. In patients with gastric cancer, we have revealed some changes of immunoregulatory peptides in blood serum that showed correlations with histological types of the tumors. Maximal baseline (pre-surgery) levels of interleukins (IL- 1β, IL-2, IL-4, IL-10) were found in highly differentiated adenocarcinoma, whereas IL-17, interferon (IFNγ) were more expressed in low differentiated carcinoma. TNFα levels were independent on histological type of the tumor. Following surgical treatment, serum concentrations of IL-1β, IL-2, IL-10 were found to be increased, along with decrease in IL-4, IL-17, IFNγ, TNFα. Following surgical treatment of gastric cancer, no septic complications were observed in the patients during the follow-up period. Our results indicate to usefulness of cytokine profile data in patients with gastric cancer during their treatment, taking into account a histological type of the tumor, in order to predict clinical course following surgical treatment.

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The authors declare that there are no conflicts of interest present.