mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2014-3-273-280mimmun-693Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИЗУЧЕНИЕ НЕКОТОРЫХ ЦИТОКИНОВ КРОВИ У БОЛЬНЫХ РЕВМАТОИДНЫМ АРТРИТОМ: КЛИНИКО- ИММУНОЛОГИЧЕСКИЕ ВЗАИМОСВЯЗИSTUDIES OF SEVERAL BLOOD CYTOKINES IN PATIENTS WITH RHEUMATOID ARTHRITIS: CLINICAL AND IMMUNOLOGAL INTERRRELATIONSПачкуноваМ. В.PachkunovaM. V.

к.м.н., старший лаборант кафедры терапии ГБОУ ВПО «Ярославская государственная медицинская академия» Минздрава России

PhD (Medicine), Senior Laboratory Assistant, Department of Therapy, Institute of Postgraduate Education, Yaroslavl State Medical Academy

pachkunov@mail.ruДаниловаТ. Г.DanilovaT. G.

д.м.н., профессор кафедры терапии ГБОУ ВПО «Ярославская государственная медицинская академия» Минздрава России

PhD, MD (Medicine), Professor, Department of Therapy, Institute of Postgraduate Education, Yaroslavl State Medical Academy

ФеофановаЕ. В.FeofanovаE. V.

аспирант кафедры терапии ГБОУ ВПО «Ярославская государственная медицинская академия» Минздрава России

Research Fellow, Department of Therapy, Institute of Postgraduate Education, Yaroslavl State Medical Academy

ГБОУ ВПО «Ярославская государственная медицинская академия» Минздрава России, г. ЯрославльРоссияYaroslavl State Medical Academy, YaroslavlRussian Federation201401082014163273280Copyright © Пачкунова М.В., Данилова Т.Г., Феофанова Е.В., 20142014Пачкунова М.В., Данилова Т.Г., Феофанова Е.В.Pachkunova M.V., Danilova T.G., Feofanovа E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/693

У больных ревматоидным артритом повышено содержание фактора некроза опухоли-αи интерферона-γ крови по сравнению с нормой. Увеличение уровня фактора некроза опухоли-α отмечается по мере роста активности воспалительного процесса, а также у больных с внесуставнымипроявлениями заболевания. Концентрация интерферона-γ достоверно связана с активностью воспалительного процесса и продолжительностью ревматоидного артрита более 1 года. Содержание фактора некроза опухоли-α и интерферона-γ крови взаимосвязано с суставным синдромом и функциональным статусом больных ревматоидным артритом.

Blood levels of tumor necrosis factor-α (TNFα) and interferon γ (IFNγ) are shown to be increased in patients with rheumatoid arthritis, as compared to normal values. An increase of TNFα levels is shown to correlate with higher activity of inflammatory process, as well as with extra-articulate lesions in patients. Concentration of IFNγ proved to be significantly connected with activity of inflammatory process, and at later terms of the disorder ( > 1 year). TNFα and IFNγ levels are interconnected with joint lesions and functional scores of patients with rheumatoid arthritis.

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The authors declare that there are no conflicts of interest present.