mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2013-6-543-552mimmun-673Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРОЛЬ КОИНФЕКЦИИ ВИРУСНЫМ ГЕПАТИТОМ С В НАРУШЕНИИ ПРОДУКТИВНОЙ ФУНКЦИИ ТИМУСА У ВИЧ-ИНФИЦИРОВАННЫХ ПАЦИЕНТОВ НА ФОНЕ ИММУНОЛОГИЧЕСКИ НЕЭФФЕКТИВНОЙ АНТИРЕТРОВИРУСНОЙ ТЕРАПИИROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPYСайдаковаЕ. В.SaidakovaE. V.

аспирант лаборатории экологической иммунологии

614081, Россия, г. Пермь, ул. Голева, 13. Тел.: 8 (342) 280-83-34. Факс: 8 (342) 280-92-11

PhD candidate, Laboratory of Ecological Immunology

614081, Goleva str., 13. Phone: 7 (342) 280-83-34. Fax: 7 (342) 280-92-11

radimira@list.ruКоролевскаяЛ. Б.KorolevskayaL. B.

к.м.н., младший научный сотрудник лаборатории экологической иммунологии

PhD (Medicine), Research Associate, Laboratory of Ecological Immunology

radimira@list.ruШмагельН. Г.ShmagelN. G.

к.м.н., врач-иммунолог

PhD (Medicine), Clinical immunologist

radimira@list.ruШмагельК. В.ShmagelK. V.

д.м.н., заместитель директора по научной работе

PhD, MD (Medicine), Deputy Director for Research

radimira@list.ruЧерешневВ. А.ChereshnevV. A.

д.м.н., профессор, академик РАН и РАМН, директор

PhD, MD (Medicine), Professor, Full Member of Russian Academy of Sciences and Russian Academy of Medical Science, Director

radimira@list.ruФГУН «Институт экологии и генетики микроорганизмов» Уральского отделения РАН, г. ПермьРоссияInstitute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences, Ural branch, PermRussian FederationГКУЗ «Пермский краевой центр по профилактике и борьбе со СПИД и инфекционными заболеваниями», г. ПермьРоссияPerm Regional Center for Protection against AIDS and Infectious Diseases, PermRussian FederationФГБУН «Институт иммунологии и физиологии» Уральского отделения РАН, г. ЕкатеринбургРоссияInstitute of Immunology and Physiology, Russian Academy of Sciences, Ural branch, EkaterinburgRussian Federation201326072014156543552Copyright © Сайдакова Е.В., Королевская Л.Б., Шмагель Н.Г., Шмагель К.В., Черешнев В.А., 20142014Сайдакова Е.В., Королевская Л.Б., Шмагель Н.Г., Шмагель К.В., Черешнев В.А.Saidakova E.V., Korolevskaya L.B., Shmagel N.G., Shmagel K.V., Chereshnev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/673

Резюме. Исследована роль коинфекции вирусным гепатитом С (ВГС) в нарушении восстановления CD4+Т-лимфоцитов у ВИЧ-инфицированных больных, получающих антиретровирусную терапию (АРТ). Обследовано 78 пациентов с эффективным вирусологическим ответом на АРТ (вирусная нагрузка < 50 копий/мл), ответивших и не ответивших ростом числа CD4+Т-клеток на терапию через два года лечения. Контрольную группу составил 21 относительно здоровый доброволец. Проведена оценка количества основных субпопуляций Т-лимфоцитов, определены темпы их гибели. Продуктивная функция тимуса оценивалась по числу αTREC-положительных CD4+ и CD8+Т-клеток. Показано, что для ВИЧ/ВГС-коинфекции характерно более низкое, по сравнению с ВИЧ-моноинфекцией, количество CD4+T-лимфоцитов в крови, что не связано с увеличенными темпами их гибели. Также продемонстрировано, что коинфекция ВГС снижает продукцию CD4+, но не CD8+T-клеток вилочковой железой.

Abstract. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated. Seventy eight patients with effective virological response to ART (viral load < 50 copies/ml) who either had or had no good immunological CD4+Tcell response after two years of treatment were recruited. Twenty one relatively healthy volunteers served as controls. The numbers of main T-lymphocyte populations and their apoptosis rates were determined. Thymus productive function was assessed by the number of αTREC-positive CD4+ and CD8+T cells. It is shown that HIV/HCV co-infection is characterized by lower numbers of CD4+T-lymphocytes in patients’ blood compared with HIV-monoinfection. This is not associated with the cells’ increased death rates. We also demonstrate that HCV coinfection reduces the production of CD4+, but not CD8+T-lymphocytes, by the thymus.

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The authors declare that there are no conflicts of interest present.