mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2013-6-503-512mimmun-670Research ArticleОБЗОРЫREVIEWSМАЛЫЕ СУБПОПУЛЯЦИИ Т-ХЕЛПЕРОВ (Th НАИВНЫЕ ТИМИЧЕСКИЕ, Th НАИВНЫЕ ЦЕНТРАЛЬНЫЕ, Th9, Th22 И CD4+CD8+ ДВАЖДЫ ПОЛОЖИТЕЛЬНЫЕ Т-КЛЕТКИ)MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)ХайдуковС. В.KhaidukovS. V.

д.б.н., заведующий лабораторией клеточной иммунологии, старший научный сотрудник 

117997, ГСП-7, ул. Миклухо-Маклая, 16/10. Тел.: 8 (985) 923-41-62

PhD, MD, Head of Laboratory of Cell Biology, Senior Research Associate

117997, GSP-7, Miklukho-Maklaya str., 16/10. Phone: 7 (985) 923-41-62

khsergey54@mail.ruФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РФ, Москва; Технопарк, ФГБУН «Институт биоорганической химии имени академиков М.М. Шемякина и Ю.А. Овчинникова» РАН, МоскваРоссияDmitry Rogachev Federal Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Russian Ministry of Health, Moscow; Technopark, M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, MoscowRussian Federation201326072014156503512Copyright © Хайдуков С.В., 20142014Хайдуков С.В.Khaidukov S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/670

Резюме. Одну из ключевых ролей в процессах, происходящих в организме при попадании чужеродного антигена, играют Т-клетки, а именно Т-хелперы (Th). Появление новых высокочувствительных инструментов позволило исследовать более тонкую структурную организацию Т-клеток, выявить среди них целый ряд функционально значимых малых субпопуляций. Данные Т-клетки были охарактеризованы как фенотипически, так и функционально. Представленный обзор посвящен Th наивным тимическим, Th наивным центральным, Th9, Th22 и CD4+CD8+ дважды положительным Т-клеткам, отражена их роль и функциональная значимость при различных патологических состояниях. В настоящее время имеются четкие данные о наличии определенных наборов мембранных молекул, транскрипционных факторов и продукции специфических медиаторов иммунной системы, отличающих эти субпопуляции.

Использование этих данных в лабораторных исследованиях, несомненно, скажется на качестве диагностики нарушений функционирования иммунной системы и адекватности назначаемой иммунотерапии.

Abstract. T cell populations, specifically, T helper (Th) cells, are among key players in the processes occurring in the body following exposure to a foreign antigen. Usage of new, highly sensitive instruments allowed of more detailed studies of their structural arrangement, as well as to detect a number of functionally significant minor subsets. These T cell subtypes were characterized both phenotypically and functionally. Present review article concerns Th thymic naїve subsets, Th central naїve subpoppulations, Th9, Th22, and CD4+CD8+ doublepositive T cells. Their role and functional significance is discussed in various pathological conditions. At present time, there are convincing data about specific arrays of membrane molecules, transcription factors, production of specific mediators typical to either of these subsets. Application of these markers in laboratory studies, will certainly improve diagnostic quality when evaluating functional alterations of immune system and adequacy of prescribed immunotherapy.

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The authors declare that there are no conflicts of interest present.