References

mimmun

Медицинская иммунология

Medical Immunology (Russia)

1563-06252313-741X

SPb RAACI

10.15789/1563-0625-2013-5-399-412

mimmun-657

Research Article

ОБЗОРЫ

REVIEWS

СВОБОДНАЯ ВНЕКЛЕТОЧНАЯ ДНК В НОРМЕ И ПРИ ПАТОЛОГИИ

FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS

Козлов

В. А.

Kozlov

V. А.

д.м.н., профессор, академик РАМН, директор

630090, ул. Ядринцевская, 14. Тел.: 8 (383) 222-66-27. Факс: 8 (383) 222-70-28

PhD, MD, Professor, Full Member of Russian Academy of Medical Sciences, Director

630090, Yadrintsevskaya str., 14. Phone: 7 (383) 222-66-27. Fax: 7 (383) 222-70-28

vakoz40@yandex.ru

ФГБУ «Научно-исследовательский институт клинической иммунологии» СО РАМН, г. НовосибирскРоссияResearch Institute of Clinical Immunology, Russian Academy of Medical Sciences, Siberian Branch, NovosibirskRussian Federation

2013

25072014

155399412

2014

Козлов В.А.

Kozlov V.А.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.mimmun.ru/mimmun/article/view/657

Abstract. The paper represents a synopsis of current publications concerning existence of free extracellular DNA. Such DNAs are not associated with cells of the organism, being revealed in nearly all body fluids. Recent data show that the cell-free DNA is determined in normal, healthy organism as well. Increased level of free DNA plasma and serum are detectable in many diseases, including autoimmune disorders, malignant neoplasias, myocardial infarction, etc. In many cases, free DNA may be suggested as predictive markers for various distinct diseases, as well as worsening of their clinical course. Physiological role of free DNA is not yet clear, like as its importance in development of certain diseases. It was shown that free DNA may exert stimulatory or suppressive effects upon functions of immunocompetent cells. Free extracellular DNA may also perform an inducing role for autoimmune conditions. In addition, one may assume that free DNA may be a carrier of genetic information in the body between tumor and normal cells in the body, like as between normal cells in various organs and tissues.

свободная внеклеточная ДНКметилированиезлокачественные клетки

free extracellular DNAmethylationmalignant cells

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The authors declare that there are no conflicts of interest present.