mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2013-4-303-312mimmun-636Research ArticleОБЗОРЫREVIEWSПАТОГЕНЕТИЧЕСКАЯ РОЛЬ КООПЕРАТИВНЫХ ВЗАИМОДЕЙСТВИЙ ТРАНСКРИПЦИОННЫХ ФАКТОРОВ FOXP3, GATA-3, РАХ -5 ПРИ БРОНХИАЛЬНОЙ АСТМЕTRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMAМинеевВ. Н.MineevV. N.

д.м.н., профессор кафедры госпитальной терапии имени академика М.В. Черноруцкого

PhD, MD (Medicine), Professor, M.V. Chernorutsky Department of Hospital Therapy

annaeremeeva@list.ruСорокинаЛ. Н.SorokinaL. N.

д.м.н., доцент кафедры госпитальной терапии имени академика М.В. Черноруцкого

PhD, MD (Medicine), Assistant Professor, M.V. Chernorutsky Department of Hospital Therapy

annaeremeeva@list.ruЕремееваА. В.EremeevaA. V.

аспирант кафедры госпитальной терапии имени академика М.В. Черноруцкого

врач-терапевт

192284, Россия, Санкт-Петербург, Дунайский пр., 48, к. 1, кв. 243. Тел.: 8 (812) 772-23-67

PhD Candidate, M.V. Chernorutsky Department of Hospital Therapy

192284, Dunaisky pr., 48, bldg 1, apt 243. Phone: 7 (812) 772-23-67

annaeremeeva@list.ruНёмаМ. А.NyomaM. A.

аспирант кафедры госпитальной терапии имени академика М.В. Черноруцкого

PhD candidate, M.V. Chernorutsky Department of Hospital Therapy

annaeremeeva@list.ruБеденкоА. С.BedenkoA. S.

студентка 5 курса

Student

annaeremeeva@list.ruСанкт-Петербургский государственный медицинский университет имени академика И.П. Павлова, Санкт-ПетербургРоссияSt. Petersburg State I.P. Pavlov Medical University, St. PetersburgRussian FederationСанкт-Петербургский государственный медицинский университет имени академика И.П. Павлова, Санкт-Петербург СПбГБУЗ «Городская поликлиника № 109»РоссияSt. Petersburg State I.P. Pavlov Medical University, St. PetersburgRussian Federation201324072014154303312Copyright © Минеев В.Н., Сорокина Л.Н., Еремеева А.В., Нёма М.А., Беденко А.С., 20142014Минеев В.Н., Сорокина Л.Н., Еремеева А.В., Нёма М.А., Беденко А.С.Mineev V.N., Sorokina L.N., Eremeeva A.V., Nyoma M.A., Bedenko A.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/636

Резюме. В настоящем обзоре подробно рассматривается функциональная роль транскрипционных факторов лимфоцитов Foxp3, GATA-3, РАХ-5 и их кооперативных взаимодействий. Преобладание одного из данных факторов приводит к выработке соответствующих цитокинов Т- и В-лимфоцитами и последующему изменению их функций, что приводит к развитию определенного типа воспаления и характерной симптоматики. Изучение FохP3, GATA-3 и РАХ-5 важно для понимания патогенетических механизмов различных патологических процессов, в частности воспалительных заболеваний легких (бронхиальной астмы), поиска и разработки новых методов лечения этих патологий. Несмотря на внимание к этому вопросу во многих странах, до сих пор нет однозначного мнения о механизмах кооперативных взаимодействий транскрипционных факторов FохP3, GATA-3 и РАХ-5. В статье излагаются современные, порой диаметрально противоположные, взгляды на данную проблему. В частности, подробно освещается регуляция экспрессии FохP3, межмолекулярные взаимодействия, влияющие на выработку РАХ-5, а также рассматриваются возможные косвенные взаимодействия этих транскрипционных факторов через реализацию функций GATA-3 и STAT6.

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The authors declare that there are no conflicts of interest present.