mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2013-3-247-254mimmun-632Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESЦИТОКИНПРОДУЦИРУЮЩИЙ ПОТЕНЦИАЛ КЛЕТОК КРОВИ И ЦИТОКИНЫ СЫВОРОТКИ БОЛЬНЫХ ХРОНИЧЕСКИМ АТРОФИЧЕСКИМ ГАСТРИТОМCYTOKINE-PRODUCING POTENTIAL OF BLOOD CELLS AND SERUM CYTOKINES IN PATIENTS WITH CHRONIC ATROPHIC GASTRITISСоснинаА. В.SosninaA. V.

к.м.н., ведущий научный сотрудник лаборатории физико-химической индикации иммунных процессов

630105, ул. Линейная, 43, кв. 29. Тел.: 8 (383) 226-39-20

PhD (Medicine), Leading Research Associate, Laboratory of Physico-Chemical Indication of Immune Processes,

lpciip@211.ruМихайловаЕ. С.MikhailovaE. S.

старший научный сотрудник лаборатории физико-химической индикации иммунных процессов

Senior Research Associate, Laboratory of Physico-Chemical Indication of Immune Processes

lpciip@211.ruАутеншлюсА. И.AutenshlyusA. I.

д.б.н., профессор, заведующий лабораторией физико-химической индикации иммунных процессов

PhD, MD (Biology), Professor, Chief, Laboratory of Physico-Chemical Indication of Immune Processes

lpciip@211.ruВараксинН. А.VaraksinN. A.

заведующий лабораторией цитокинов

Chief, The Cytokine Laboratory

lpciip@211.ruДотолеваН. А.DotolevaN. A.

врач-эндоскопист

Physician (Endoscopist)

lpciip@211.ruМихноИ. П.MikhnoI. P.

врач-патологоанатом

Pathologist

lpciip@211.ruАгееваТ. А.AgeevaT. A.

д.м.н., профессор, профессор кафедры патологической анатомии лечебного факультета

MD, Professor, Department of Pathological Anatomy, Therapeutic Faculty

lpciip@211.ruШпагинаЛ. А.ShpaginaL. A.

д.м.н., профессор, заведующая кафедрой госпитальной терапии и медицинской реабилитации педиатрического факультета

PhD, MD (Medicine), Professor, Chief, Department of Hospital Therapy and Medical Rehabilitation, Pediatric Faculty

lpciip@211.ruФГБУ «Научно-исследовательский институт молекулярной биологии и биофизики» СО РАМН, г. НовосибирскРоссияResearch Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Branch, NovosibirskRussian FederationЗАО «Вектор-Бест», Новосибирская обл.РоссияVector Best Ltd, Novosibirsk RegionRussian FederationГБОУ ВПО «Новосибирский государственный медицинский университет», г. НовосибирскРоссияNovosibirsk State Medical University, NovosibirskRussian Federation201324072014153247254Copyright © Соснина А.В., Михайлова Е.С., Аутеншлюс А.И., Вараксин Н.А., Дотолева Н.А., Михно И.П., Агеева Т.А., Шпагина Л.А., 20142014Соснина А.В., Михайлова Е.С., Аутеншлюс А.И., Вараксин Н.А., Дотолева Н.А., Михно И.П., Агеева Т.А., Шпагина Л.А.Sosnina A.V., Mikhailova E.S., Autenshlyus A.I., Varaksin N.A., Dotoleva N.A., Mikhno I.P., Ageeva T.A., Shpagina L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/632

Резюме. Исследовали цитокинпродуцирующий потенциал клеток крови, оцениваемый по индексу влияния поликлональных активаторов, представляющему собой отношение уровня стимулированной поликлональными активаторами продукции цитокина к уровню его спонтанной продукции, а также концентрацию цитокинов в сыворотке крови больных хроническим атрофическим гастритом. Было выявлено, что у больных с дисплазией слизистой оболочки желудка повышены индексы влияния поликлональных активаторов на продукцию клетками крови TNFα, IL-1β, IL-6, IL-8 и IL- 10 и концентрация IL-8 и IL-18BP в сыворотке крови по сравнению с больными без дисплазии. Установлено, что пациенты с величинами индексов влияния поликлональных активаторов на продукцию клетками крови IL-6 не ниже 164 условных единиц и IL-8 не ниже 38 условных единиц должны быть отнесены к группе риска по развитию дисплазии эпителия слизистой оболочки желудка.

Abstract. Cytokine-producing potential of peripheral blood cells was determined as a stimulation index with polyclonal activators (i.e., a cytokine production ratio of stimulated versus resting cells), as well as concentrations of cytokines were investigated in blood serum of patients with chronic atrophic gastritis. It was revealed that the stimulation indices concerning production of TNFα, IL-1β, IL-6, IL-8 and IL-10 by whole blood cells, along with serum concentrations of IL-8 and IL-18BP were increased in patients with epithelial dysplasia of stomach mucosa, as compared to patients without dysplasia. It was sahown, that the patients with higher polyclonal stimulation indices for IL-6 and IL-8 (resp., > 164 and > 38 arbitrary units) should be referred to a high-risk group for development of mucous epithelial dysplasia of stomach.

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The authors declare that there are no conflicts of interest present.