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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2005-5-6-575-578</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-628</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SHORT COMMUNICATIONS</subject></subj-group></article-categories><title-group><article-title>КРАТКИЕ СООБЩЕНИЯ СОДЕРЖАНИЕ РАСТВОРИМОГО РЕЦЕПТОРА TNF-P55, АЛЬФА-ДЕФЕНЗИНОВ И ИЗОФОРМ ИНТЕРЛЕЙКИНА-8, IL-877 И IL-872 В КРОВИ ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>THE LEVELS OF SOLUBLE RECEPTOR OF TUMOR NECROSIS FACTOR P55, TNF, NEUTROPHIL-DERIVED ALPHA-DEFENSINS AND BOTH ISOFORMS OF INTERLEUKIN-8 IN THE BLOOD AND CEREBROSPINAL FLUID (CSF) FROM CHILDREN WITH GENERALIZED FORMS OF MENINGOCOCCAL INFECTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акалович</surname><given-names>С. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Akalovich</surname><given-names>S. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>222720, г. Дзержинск, ул. Кирова, д.10, кв.30</p></bio><email xlink:type="simple">svkoleda@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нашкевич</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Nashkevich</surname><given-names>N. N.</given-names></name></name-alternatives><email xlink:type="simple">svkoleda@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудин</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudin</surname><given-names>A. P.</given-names></name></name-alternatives><email xlink:type="simple">svkoleda@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Астапов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Astapov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">svkoleda@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Войтенок</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Voitenok</surname><given-names>N. N.</given-names></name></name-alternatives><email xlink:type="simple">svkoleda@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>РНПЦ гематологии и трансфузиологии МЗ РБ, Минск</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Белорусский государственный медицинский университет, Минск</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-3"><institution>Фонд развития молекулярной гематологии и иммунологии, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2005</year></pub-date><pub-date pub-type="epub"><day>24</day><month>07</month><year>2014</year></pub-date><volume>7</volume><issue>5-6</issue><fpage>575</fpage><lpage>578</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Акалович С.Т., Нашкевич Н.Н., Кудин А.П., Астапов А.А., Войтенок Н.Н., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Акалович С.Т., Нашкевич Н.Н., Кудин А.П., Астапов А.А., Войтенок Н.Н.</copyright-holder><copyright-holder xml:lang="en">Akalovich S.T., Nashkevich N.N., Kudin A.P., Astapov A.A., Voitenok N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/628">https://www.mimmun.ru/mimmun/article/view/628</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>р55</kwd><kwd>TNF</kwd><kwd>IL–8</kwd><kwd>дефензины</kwd><kwd>системный воспалительный ответ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>р55</kwd><kwd>TNF</kwd><kwd>IL–8</kwd><kwd>defensins</kwd><kwd>systemic inflammatory response</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., Schein R.M., Sibbald W.J. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians / Society of Critical Care Medicine // Chest. — 1992. — V. 101. — P. 1644–1655.</mixed-citation><mixed-citation xml:lang="en">Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., Schein R.M., Sibbald W.J. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians / Society of Critical Care Medicine // Chest. — 1992. — V. 101. — P. 1644–1655.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Casey L.C. Immunologic response to infection and its role in septic shock // Crit. Care Clin. — 2000. — V. 16. — P. 193–213.</mixed-citation><mixed-citation xml:lang="en">Casey L.C. Immunologic response to infection and its role in septic shock // Crit. Care Clin. — 2000. — V. 16. — P. 193–213.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Redl H., Schlag G., Adolf G.R., Natmessnig B., Davies J. Tumor necrosis factor (TNF) dependent shedding of the p55 TNF receptors in a baboon model of bacteremia // Infection and Immunity. — 1995. — V. 63. — Р. 12–16.</mixed-citation><mixed-citation xml:lang="en">Redl H., Schlag G., Adolf G.R., Natmessnig B., Davies J. Tumor necrosis factor (TNF) dependent shedding of the p55 TNF receptors in a baboon model of bacteremia // Infection and Immunity. — 1995. — V. 63. — Р. 12–16.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gogos C.A., Drosou E., Bassaris H.P., Skoutelis A. Pro– versus anti–inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options // J Infect Dis. — 2000. — V. 181. — P. 176–180.</mixed-citation><mixed-citation xml:lang="en">Gogos C.A., Drosou E., Bassaris H.P., Skoutelis A. Pro– versus anti–inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options // J Infect Dis. — 2000. — V. 181. — P. 176–180.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kornelisse R.F., Savelkoul H.F., Mulder P.H., Suur M.H., van der Straaten P.J., van der Heijden A.J., Sukhai R.N., Hahlen K., Neijens H.J., de Groot R. Interleukin10 and soluble tumor necrosis factor receptors in cerebrospinal fluid of children with bacterial meningitis // J Infect Dis. — 1996. — 173. — P. 1498–1502.</mixed-citation><mixed-citation xml:lang="en">Kornelisse R.F., Savelkoul H.F., Mulder P.H., Suur M.H., van der Straaten P.J., van der Heijden A.J., Sukhai R.N., Hahlen K., Neijens H.J., de Groot R. Interleukin10 and soluble tumor necrosis factor receptors in cerebrospinal fluid of children with bacterial meningitis // J Infect Dis. — 1996. — 173. — P. 1498–1502.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Warzocha K., Salles G., Bienvenu J., Barbier Y., Bastion Y., Doche C., Rieux C., Coiffier B. Prognostic significance of TNF alpha and its p55 soluble receptor in malignant lymphomas // Leukemia. — 1997. — V. 11. — P.441–443.</mixed-citation><mixed-citation xml:lang="en">Warzocha K., Salles G., Bienvenu J., Barbier Y., Bastion Y., Doche C., Rieux C., Coiffier B. Prognostic significance of TNF alpha and its p55 soluble receptor in malignant lymphomas // Leukemia. — 1997. — V. 11. — P.441–443.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fauci A.S. Host factors and the pathogenesis of HIV–induced disease // Nature. — 1996. — V. 384. — P. 529–534.</mixed-citation><mixed-citation xml:lang="en">Fauci A.S. Host factors and the pathogenesis of HIV–induced disease // Nature. — 1996. — V. 384. — P. 529–534.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshimura T., Robinson E.A., Appella E., Matsushima K., Showalter S.D., Skeel A., Leonard E.J. Three forms of monocyte–derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino–terminal sequence // Mol. Immunol. — 1989. — V. 26. — P. 87–93.</mixed-citation><mixed-citation xml:lang="en">Yoshimura T., Robinson E.A., Appella E., Matsushima K., Showalter S.D., Skeel A., Leonard E.J. Three forms of monocyte–derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino–terminal sequence // Mol. Immunol. — 1989. — V. 26. — P. 87–93.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Halstensen A., Ceska M., Brandtzaeg P., Redl H., Naess A., Waage A. Interleukin–8 in serum and cerebrospinal fluid from patients with meningococcal disease // J Infect Dis. — 1993. — V. 167. — P. 471–475.</mixed-citation><mixed-citation xml:lang="en">Halstensen A., Ceska M., Brandtzaeg P., Redl H., Naess A., Waage A. Interleukin–8 in serum and cerebrospinal fluid from patients with meningococcal disease // J Infect Dis. — 1993. — V. 167. — P. 471–475.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gudmundsson G.H., Agerberth B. Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system // J Immunol Methods. — 1999. — V. 232. — P. 45–54.</mixed-citation><mixed-citation xml:lang="en">Gudmundsson G.H., Agerberth B. Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system // J Immunol Methods. — 1999. — V. 232. — P. 45–54.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ganz T. Antimicrobial polypeptides in host defense of the respiratory tract // J Clin Invest. — 2002. — V. 109. — P. 693–697.</mixed-citation><mixed-citation xml:lang="en">Ganz T. Antimicrobial polypeptides in host defense of the respiratory tract // J Clin Invest. — 2002. — V. 109. — P. 693–697.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Panyutich A.V., Panyutich E.A., Krapivin V.A., Baturevich E.A., Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis // J. Lab. Clin. Med. — 1993. — V. 122. — P. 202–207.</mixed-citation><mixed-citation xml:lang="en">Panyutich A.V., Panyutich E.A., Krapivin V.A., Baturevich E.A., Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis // J. Lab. Clin. Med. — 1993. — V. 122. — P. 202–207.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Н.В.Петёвка, Н.Н.Нашкевич, И.И.Тихонов, Т.С.Колесникова, С.Т.Коледа, С.С.Бутенко, Т.М.Дорошенко, Н.Н.Войтенок. Иммуноферментный метод определения растворимого Р55 рецептора TNF человека // Клиническая аллергология и иммунология. Иммунодиагностика и иммунореабилитация. Сб. трудов 2–й Международной конференции и 1 съезда БААКИ. / Минск–Витебск, 1998. – С. 193–195.</mixed-citation><mixed-citation xml:lang="en">Н.В.Петёвка, Н.Н.Нашкевич, И.И.Тихонов, Т.С.Колесникова, С.Т.Коледа, С.С.Бутенко, Т.М.Дорошенко, Н.Н.Войтенок. Иммуноферментный метод определения растворимого Р55 рецептора TNF человека // Клиническая аллергология и иммунология. Иммунодиагностика и иммунореабилитация. Сб. трудов 2–й Международной конференции и 1 съезда БААКИ. / Минск–Витебск, 1998. – С. 193–195.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Panyutich A.V., Voitenok N.N., Lehrer R.I., Ganz T. An enzyme immunoassay for human defensins // J. Immunol. Methods. — 1991. — V. 141. — P. 149–155.</mixed-citation><mixed-citation xml:lang="en">Panyutich A.V., Voitenok N.N., Lehrer R.I., Ganz T. An enzyme immunoassay for human defensins // J. Immunol. Methods. — 1991. — V. 141. — P. 149–155.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nashkevich N.N., Akalovich S., Louneva N., Heavner G.A., Voitenok N. N. A monoclonal antibody and an enzyme immunoassay for human Ala–IL–8(77) // J Immunol Methods. — 2002. — V. 270. — P. 37–51.</mixed-citation><mixed-citation xml:lang="en">Nashkevich N.N., Akalovich S., Louneva N., Heavner G.A., Voitenok N. N. A monoclonal antibody and an enzyme immunoassay for human Ala–IL–8(77) // J Immunol Methods. — 2002. — V. 270. — P. 37–51.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Petyovka N., Lyakh, L., Voitenok N.N. Homologous ELISA for detection of oligomeric human TNF: properties of the assay // J. Immunol. Methods. — 1995. – V. 186. — P. 161–170.</mixed-citation><mixed-citation xml:lang="en">Petyovka N., Lyakh, L., Voitenok N.N. Homologous ELISA for detection of oligomeric human TNF: properties of the assay // J. Immunol. Methods. — 1995. – V. 186. — P. 161–170.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ganz T., Selsted M.E., Szklarek D., Harwig S.S., Daher K., Bainton D.F., Lehrer R.I. Dens. Natural peptide antibiotics of human neutrophils // J. Clin. Invest. – 1985. — V. 76. — P. 1427–1435.</mixed-citation><mixed-citation xml:lang="en">Ganz T., Selsted M.E., Szklarek D., Harwig S.S., Daher K., Bainton D.F., Lehrer R.I. Dens. Natural peptide antibiotics of human neutrophils // J. Clin. Invest. – 1985. — V. 76. — P. 1427–1435.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sylvester I., Yoshimura T., Sticherling M., Schroder J.M., Ceska M., Peichl P., Leonard E.J. Neutrophil attractant protein–1–immunoglobulin G immune and free anti–NAP–1 antibody in normal human serum // J. Clin. Invest. — 1992. — V. 90. — P. 471–481.</mixed-citation><mixed-citation xml:lang="en">Sylvester I., Yoshimura T., Sticherling M., Schroder J.M., Ceska M., Peichl P., Leonard E.J. Neutrophil attractant protein–1–immunoglobulin G immune and free anti–NAP–1 antibody in normal human serum // J. Clin. Invest. — 1992. — V. 90. — P. 471–481.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
