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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2012-6-461-482</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-534</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>СОВРЕМЕННЫЕ МЕТОДЫ И ПОДХОДЫ К ИЗУЧЕНИЮ АПОПТОЗА В ЭКСПЕРИМЕНТАЛЬНОЙ БИОЛОГИИ</article-title><trans-title-group xml:lang="en"><trans-title>MODERN TECHNOLOGIES AND APPROACHES TO APOPTOSIS STUDIES IN EXPERIMENTAL BIOLOGY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудрявцев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudriavtsev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>К.б.н., отдел иммунологии, 197376, Санкт-Петербург, ул. акад. Павлова, 12.</p></bio><email xlink:type="simple">igorek1981@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головкин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovkin</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">igorek1981@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зурочка</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zurochka</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">igorek1981@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хайдуков</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khaidukov</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">igorek1981@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ «НИИ экспериментальной медицины» СЗО РАМН, Санкт-Петербург</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Федеральное бюджетное государственное учреждение науки Институт иммунологии и физиологии&#13;
Уральского отделения РАН, г. Екатеринбург</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>ФГБУ Федеральный Научно-Клинический Центр детской гематологии, онкологии и иммунологии им.&#13;
Дмитрия Рогачева, Москва; ФГБУН Институт биоорганической химии им. академиков М.М. Шемякина&#13;
и Ю.А. Овчинникова РАН, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>23</day><month>07</month><year>2014</year></pub-date><volume>14</volume><issue>6</issue><fpage>461</fpage><lpage>482</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кудрявцев И.В., Головкин А.С., Зурочка А.В., Хайдуков С.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Кудрявцев И.В., Головкин А.С., Зурочка А.В., Хайдуков С.В.</copyright-holder><copyright-holder xml:lang="en">Kudriavtsev I.V., Golovkin A.S., Zurochka A.V., Khaidukov S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/534">https://www.mimmun.ru/mimmun/article/view/534</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>апоптоз</kwd><kwd>критерии</kwd><kwd>методы оценки</kwd><kwd>межвидовые сравнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>apoptosis</kwd><kwd>criteria</kwd><kwd>evaluation techniques</kwd><kwd>interspecies comparisons.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Abdelwahid E., Rolland S., Teng X., Conradt B., Hardwick J.M., White K. Mitochondrial involvement in cell death of non-mammalian eukaryotes // Biochim. Biophys. Acta. – 2011. – Vol. 1813. – P. 597-607.</mixed-citation><mixed-citation xml:lang="en">Abdelwahid E., Rolland S., Teng X., Conradt B., Hardwick J.M., White K. Mitochondrial involvement in cell death of non-mammalian eukaryotes // Biochim. Biophys. Acta. – 2011. – Vol. 1813. – P. 597-607.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Adams S.L., Hessian P.A., Mladenov Ph.V. Flow cytometric evaluation of mitochondrial function and membrane integrity of marine invertebrate sperm // Invert. Reprod. Dev. – 2003. – Vol. 44. – P. 45-51.</mixed-citation><mixed-citation xml:lang="en">Adams S.L., Hessian P.A., Mladenov Ph.V. Flow cytometric evaluation of mitochondrial function and membrane integrity of marine invertebrate sperm // Invert. Reprod. Dev. – 2003. – Vol. 44. – P. 45-51.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Agnello M, Roccheri MC. Apoptosis: Focus on sea urchin development // Apoptosis. – 2010. – Vol. 15. – P. 322-330.</mixed-citation><mixed-citation xml:lang="en">Agnello M, Roccheri MC. Apoptosis: Focus on sea urchin development // Apoptosis. – 2010. – Vol. 15. – P. 322-330.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Baulny B.O., Vern Y., Kerboeuf D., Maisse G. Flow cytometric evaluation of mitochondrial activity and membrane integrity in fresh and cryopreserved rainbow trout (Oncorhynchus mykiss) spermatozoa // Cryobiology. – 1997. – Vol. 34. – P. 141-149.</mixed-citation><mixed-citation xml:lang="en">Baulny B.O., Vern Y., Kerboeuf D., Maisse G. Flow cytometric evaluation of mitochondrial activity and membrane integrity in fresh and cryopreserved rainbow trout (Oncorhynchus mykiss) spermatozoa // Cryobiology. – 1997. – Vol. 34. – P. 141-149.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Betti M., Ciacci C., Lorusso L.C., Canonico B., Falcioni T., Gallo G., Canesi L. Effects of tumour necrosis factor α (TNFα) on Mytilus haemocytes: role of stress-activated mitogenactivated protein kinases (MAPKs) // Biol. Cell. – 2006. – Vol. 98. – P. 233-244.</mixed-citation><mixed-citation xml:lang="en">Betti M., Ciacci C., Lorusso L.C., Canonico B., Falcioni T., Gallo G., Canesi L. Effects of tumour necrosis factor α (TNFα) on Mytilus haemocytes: role of stress-activated mitogenactivated protein kinases (MAPKs) // Biol. Cell. – 2006. – Vol. 98. – P. 233-244.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bihari N., Micic M., Batel R., Zahn R.K. Flow cytometric detection of DNA cell cycle alterations in hemocytes of mussels (Mytilus galloprovincialis) off the Adriatic coast, Croatia // Aquatic Toxicol. – 2003. – Vol. 64. – P. 121-129.</mixed-citation><mixed-citation xml:lang="en">Bihari N., Micic M., Batel R., Zahn R.K. Flow cytometric detection of DNA cell cycle alterations in hemocytes of mussels (Mytilus galloprovincialis) off the Adriatic coast, Croatia // Aquatic Toxicol. – 2003. – Vol. 64. – P. 121-129.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Blankenberg F.G. In vivo imaging of apoptosis // Cancer Biol. Ther. – 2008. – Vol. 7. – P. 1525-1532.</mixed-citation><mixed-citation xml:lang="en">Blankenberg F.G. In vivo imaging of apoptosis // Cancer Biol. Ther. – 2008. – Vol. 7. – P. 1525-1532.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Canesi L., Ciacci C., Betti M., Fabbri R., anonico B., Fantinati A., Marcomini A., Pojana G. Immunotoxicity of carbon black nanoparticles to blue mussel hemocytes // Envir. International. – 2008. – Vol. 34. – P. 1114-1119.</mixed-citation><mixed-citation xml:lang="en">Canesi L., Ciacci C., Betti M., Fabbri R., anonico B., Fantinati A., Marcomini A., Pojana G. Immunotoxicity of carbon black nanoparticles to blue mussel hemocytes // Envir. International. – 2008. – Vol. 34. – P. 1114-1119.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chang M.X., Wang Y.P., Nie P. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways // Fish Shellfish Immunol. – 2009. – Vol. 26. – P. 264-274.</mixed-citation><mixed-citation xml:lang="en">Chang M.X., Wang Y.P., Nie P. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways // Fish Shellfish Immunol. – 2009. – Vol. 26. – P. 264-274.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chowdhury I., Tharakan B., Bhat G.K. Caspases - An update // Comp. Biochem. Physiol., Part B. – 2008. – Vol. 151. – P. 10-27.</mixed-citation><mixed-citation xml:lang="en">Chowdhury I., Tharakan B., Bhat G.K. Caspases - An update // Comp. Biochem. Physiol., Part B. – 2008. – Vol. 151. – P. 10-27.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Cima F., Manni L., Basso G., Fortunato E., Accordi B., Schiavon F., Ballarin L. Hovering between death and life: Natural apoptosis and phagocytes in the blastogenetic cycle of the colonial ascidian Botryllus schlosseri // Dev. Comp. Immunol. – 2010. – Vol. 34. – P. 272-285.</mixed-citation><mixed-citation xml:lang="en">Cima F., Manni L., Basso G., Fortunato E., Accordi B., Schiavon F., Ballarin L. Hovering between death and life: Natural apoptosis and phagocytes in the blastogenetic cycle of the colonial ascidian Botryllus schlosseri // Dev. Comp. Immunol. – 2010. – Vol. 34. – P. 272-285.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cooper D.M., Granville D.J., Lowenberger C. The insect caspases // Apoptosis. – 2009. – Vol. 14. – P. 247-256.</mixed-citation><mixed-citation xml:lang="en">Cooper D.M., Granville D.J., Lowenberger C. The insect caspases // Apoptosis. – 2009. – Vol. 14. – P. 247-256.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cottet-Rousselle C., Ronot X., Leverve X., Mayol J.-F. Cytometric assessment of mitochondria using fluorescent probes // Cytometry Part A. – 2011. – Vol. 79A. – P. 405-425.</mixed-citation><mixed-citation xml:lang="en">Cottet-Rousselle C., Ronot X., Leverve X., Mayol J.-F. Cytometric assessment of mitochondria using fluorescent probes // Cytometry Part A. – 2011. – Vol. 79A. – P. 405-425.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Darzynkiewicz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M.A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry // Cytometry. – 1992. – Vol. 13. – P. 795-808.</mixed-citation><mixed-citation xml:lang="en">Darzynkiewicz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M.A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry // Cytometry. – 1992. – Vol. 13. – P. 795-808.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Darzynkiewicz Z., Huang X., Okafuji M. Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication) // Methods Mol. Biol. – 2006. – Vol. 314. – P. 81-93.</mixed-citation><mixed-citation xml:lang="en">Darzynkiewicz Z., Huang X., Okafuji M. Detection of DNA strand breaks by flow and laser scanning cytometry in studies of apoptosis and cell proliferation (DNA replication) // Methods Mol. Biol. – 2006. – Vol. 314. – P. 81-93.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Delaporte M., Synard S., Pariseau J., McKenna P., Tremblay R., Davidson J., Berthe F.C.J. Assessment of haemic neoplasia in different soft shell clam Mya arenaria populations from eastern Canada by flow cytometry // J. Invert. Pathol. – 2008. – Vol. 98. – P. 190-197.</mixed-citation><mixed-citation xml:lang="en">Delaporte M., Synard S., Pariseau J., McKenna P., Tremblay R., Davidson J., Berthe F.C.J. Assessment of haemic neoplasia in different soft shell clam Mya arenaria populations from eastern Canada by flow cytometry // J. Invert. Pathol. – 2008. – Vol. 98. – P. 190-197.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Deveraux Q.L., Reed J.C. IAP family proteins – suppressors of apoptosis // Genes Dev. – 1999. – Vol. 13. – P. 239-252.</mixed-citation><mixed-citation xml:lang="en">Deveraux Q.L., Reed J.C. IAP family proteins – suppressors of apoptosis // Genes Dev. – 1999. – Vol. 13. – P. 239-252.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Devitt A., Marshall L.J. The innate immune system and the clearance of apoptotic cells // J. Leukoc. Biol. – 2011. – Vol. 90. – P. 447-457.</mixed-citation><mixed-citation xml:lang="en">Devitt A., Marshall L.J. The innate immune system and the clearance of apoptotic cells // J. Leukoc. Biol. – 2011. – Vol. 90. – P. 447-457.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dive C., Gregory C.D., Phipps D.J., Evans D.L., Milner A.E., Wyllieч A.H. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry // Biochim. Biophys. Acta. – 1992. – Vol. 1133. – P. 275-285.</mixed-citation><mixed-citation xml:lang="en">Dive C., Gregory C.D., Phipps D.J., Evans D.L., Milner A.E., Wyllieч A.H. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry // Biochim. Biophys. Acta. – 1992. – Vol. 1133. – P. 275-285.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ducoroy P., Lesourd M., Padros M.R., Tournefier A. Natural and induced apoptosis during lymphocyte development in the axolotl // Dev. Comp. Immunol. – 1999. – Vol. 23. – P. 241-252.</mixed-citation><mixed-citation xml:lang="en">Ducoroy P., Lesourd M., Padros M.R., Tournefier A. Natural and induced apoptosis during lymphocyte development in the axolotl // Dev. Comp. Immunol. – 1999. – Vol. 23. – P. 241-252.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Elliott M.R., Ravichandran K.S. Clearance of apoptotic cells: implications in health and disease // J. Cell Biol. – 2010. – Vol. 189. – P. 1059-1070.</mixed-citation><mixed-citation xml:lang="en">Elliott M.R., Ravichandran K.S. Clearance of apoptotic cells: implications in health and disease // J. Cell Biol. – 2010. – Vol. 189. – P. 1059-1070.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Elmore S. Apoptosis: a review of programmed cell death // Toxicol. Pathol. – 2007. – Vol. 35. – P. 495-516.</mixed-citation><mixed-citation xml:lang="en">Elmore S. Apoptosis: a review of programmed cell death // Toxicol. Pathol. – 2007. – Vol. 35. – P. 495-516.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Engelsma M.Y., Hougee S., Nap D., Hofenk M., Rombout J.H.W.M., van Muiswinkel W.B., Verburg-van Kemenade B.M.L. Multiple acute temperature stress affects leucocyte populations and antibody responses in common carp, Cyprinus carpio L. // Fish Shellfish Immunol. – 2003. – Vol. 15. – P. 397-410.</mixed-citation><mixed-citation xml:lang="en">Engelsma M.Y., Hougee S., Nap D., Hofenk M., Rombout J.H.W.M., van Muiswinkel W.B., Verburg-van Kemenade B.M.L. Multiple acute temperature stress affects leucocyte populations and antibody responses in common carp, Cyprinus carpio L. // Fish Shellfish Immunol. – 2003. – Vol. 15. – P. 397-410.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fan Т., Han L., Cong R., Liang J. Caspase family proteases and apoptosis // Acta Biochim. Biophys. Sin. (Shanghai). – 2005. – Vol. 37. – P. 719-727.</mixed-citation><mixed-citation xml:lang="en">Fan Т., Han L., Cong R., Liang J. Caspase family proteases and apoptosis // Acta Biochim. Biophys. Sin. (Shanghai). – 2005. – Vol. 37. – P. 719-727.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Favret K.P., Lynn J.W. Flow-cytometric analyses of viability biomarkers in pesticide-exposed sperm of three aquatic invertebrates // Arch. Environ. Contam. Toxicol. – 2010. – Vol. 58. – P. 973-984.</mixed-citation><mixed-citation xml:lang="en">Favret K.P., Lynn J.W. Flow-cytometric analyses of viability biomarkers in pesticide-exposed sperm of three aquatic invertebrates // Arch. Environ. Contam. Toxicol. – 2010. – Vol. 58. – P. 973-984.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ferlini C., Scambia G.. Assay for apoptosis using the mitochondrial probes, Rhodamine123 and 10-N-nonyl acridine orange // Nature Protocols. – 2007. – Vol. 2. – P. 3111-3114.</mixed-citation><mixed-citation xml:lang="en">Ferlini C., Scambia G.. Assay for apoptosis using the mitochondrial probes, Rhodamine123 and 10-N-nonyl acridine orange // Nature Protocols. – 2007. – Vol. 2. – P. 3111-3114.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Filipiak M., Bilska E., Tylko G., Pyza E. Effects of zinc on programmed cell death of Musca domestica and Drosophila melanogaster blood cells // J. Insect Physiol. – 2010. – Vol. 56. – P. 383-390.</mixed-citation><mixed-citation xml:lang="en">Filipiak M., Bilska E., Tylko G., Pyza E. Effects of zinc on programmed cell death of Musca domestica and Drosophila melanogaster blood cells // J. Insect Physiol. – 2010. – Vol. 56. – P. 383-390.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Friedl F.E., Alvarez M.R., Johnson J.S., Gratzner H.G. Cytometric investigations on hemocytes of the American oyster, Crassostrea virginica // Tissue Cell. – 1988. – Vol. 20. – P. 933-939.</mixed-citation><mixed-citation xml:lang="en">Friedl F.E., Alvarez M.R., Johnson J.S., Gratzner H.G. Cytometric investigations on hemocytes of the American oyster, Crassostrea virginica // Tissue Cell. – 1988. – Vol. 20. – P. 933-939.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Galliot B., Chera S. The Hydra model: disclosing an apoptosis-driven generator of Wnt-based regeneration // Trends Cell Biol. – 2010. – Vol. 20. – P. 514-523.</mixed-citation><mixed-citation xml:lang="en">Galliot B., Chera S. The Hydra model: disclosing an apoptosis-driven generator of Wnt-based regeneration // Trends Cell Biol. – 2010. – Vol. 20. – P. 514-523.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Garner D.L., Johnson L.A. Viability assessment of mammalian sperm using SYBR-14 and propidium iodide // Biol. Reprod. – 1995. – Vol. 53. – P. 276-284.</mixed-citation><mixed-citation xml:lang="en">Garner D.L., Johnson L.A. Viability assessment of mammalian sperm using SYBR-14 and propidium iodide // Biol. Reprod. – 1995. – Vol. 53. – P. 276-284.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Garner D.L., Johnson L.A., Yue S.T., Roth B.L., Haugland R.P. Dual DNA staining assessment of bovine sperm viability using SYBR-14 and propidium iodide // J. Androl. – 1994. – Vol. 15. – P. 620-629.</mixed-citation><mixed-citation xml:lang="en">Garner D.L., Johnson L.A., Yue S.T., Roth B.L., Haugland R.P. Dual DNA staining assessment of bovine sperm viability using SYBR-14 and propidium iodide // J. Androl. – 1994. – Vol. 15. – P. 620-629.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gorczyca W., Gong J., Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays // Cancer Res. – 1993. – Vol. 53. – P. 1945-1951.</mixed-citation><mixed-citation xml:lang="en">Gorczyca W., Gong J., Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays // Cancer Res. – 1993. – Vol. 53. – P. 1945-1951.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hood K.A., West L.M., Northcote P.T., Berridge M.V., Miller J.H. Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine // Apoptosis. – 2001. – Vol. 6. – P. 207-219.</mixed-citation><mixed-citation xml:lang="en">Hood K.A., West L.M., Northcote P.T., Berridge M.V., Miller J.H. Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine // Apoptosis. – 2001. – Vol. 6. – P. 207-219.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson L.V., Walsh M.L., Chen, L.B. Localization of mitochondria in living cells with rhodamine 123 // PNAS. – 1980. – Vol. 77. – P. 990-994.</mixed-citation><mixed-citation xml:lang="en">Johnson L.V., Walsh M.L., Chen, L.B. Localization of mitochondria in living cells with rhodamine 123 // PNAS. – 1980. – Vol. 77. – P. 990-994.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Kerr J., Wyllie A., Сurrie A. Apoptosis: a basic biological phenomenon with wide-ranging applications in tissue kinetic // British J. Cancer. – 1972. – Vol. 26. – P. 237-251.</mixed-citation><mixed-citation xml:lang="en">Kerr J., Wyllie A., Сurrie A. Apoptosis: a basic biological phenomenon with wide-ranging applications in tissue kinetic // British J. Cancer. – 1972. – Vol. 26. – P. 237-251.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kiss T. Apoptosis and its functional significance in mollusks // Apoptosis. – 2010. – Vol. 15. – P. 313-321.</mixed-citation><mixed-citation xml:lang="en">Kiss T. Apoptosis and its functional significance in mollusks // Apoptosis. – 2010. – Vol. 15. – P. 313-321.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kitazumi I., Tsukahara M. Regulation of DNA fragmentation: the role of caspases and phosphorylation // FEBS J. – 2011. – Vol. 278. – P. 427-441.</mixed-citation><mixed-citation xml:lang="en">Kitazumi I., Tsukahara M. Regulation of DNA fragmentation: the role of caspases and phosphorylation // FEBS J. – 2011. – Vol. 278. – P. 427-441.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Lasi M., David C.N., Bottger A. Apoptosis in pre-Bilaterians: Hydra as a model // Apoptosis. – 2010. – Vol. 15. – P. 269-278.</mixed-citation><mixed-citation xml:lang="en">Lasi M., David C.N., Bottger A. Apoptosis in pre-Bilaterians: Hydra as a model // Apoptosis. – 2010. – Vol. 15. – P. 269-278.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Le Grand F., Kraffe E., de Montaudouin X., Villalba A., Marty Y., Soudant P. Prevalence, intensity, and aneuploidy patterns of disseminated neoplasia in cockles (Cerastoderma edule) from Arcachon Bay: Seasonal variation and position in sediment // J. Invert. Pathol. – 2010. – Vol. 104. – P. 110-118.</mixed-citation><mixed-citation xml:lang="en">Le Grand F., Kraffe E., de Montaudouin X., Villalba A., Marty Y., Soudant P. Prevalence, intensity, and aneuploidy patterns of disseminated neoplasia in cockles (Cerastoderma edule) from Arcachon Bay: Seasonal variation and position in sediment // J. Invert. Pathol. – 2010. – Vol. 104. – P. 110-118.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Lee B.W., Olin M.R., Johnson G.L., Griffin R.J. In vitro and in vivo apoptosis detection using membrane permeant fluorescent-labeled inhibitors of caspases // Meth. Mol. Biol. – 2008. – Vol. 414. – P. 109-135.</mixed-citation><mixed-citation xml:lang="en">Lee B.W., Olin M.R., Johnson G.L., Griffin R.J. In vitro and in vivo apoptosis detection using membrane permeant fluorescent-labeled inhibitors of caspases // Meth. Mol. Biol. – 2008. – Vol. 414. – P. 109-135.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Lezcano M., Granja C., Salazar M. The use of flow cytometry in the evaluation of cell viability of cryopreserved sperm of the marine shrimp (Litopenaeus vannamei) // Cryobiology. – 2004. – Vol. 48. – P. 349-356.</mixed-citation><mixed-citation xml:lang="en">Lezcano M., Granja C., Salazar M. The use of flow cytometry in the evaluation of cell viability of cryopreserved sperm of the marine shrimp (Litopenaeus vannamei) // Cryobiology. – 2004. – Vol. 48. – P. 349-356.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Li X., Darzynkiewicz Z. Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation // Cell Prolif. – 1995. – Vol. 28. – P. 571-579.</mixed-citation><mixed-citation xml:lang="en">Li X., Darzynkiewicz Z. Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation // Cell Prolif. – 1995. – Vol. 28. – P. 571-579.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Liu L., Wu C., Chen T., Zhang X., Lia F., Luo W., Xiang J. Effects of infection of EGFP-expressing Escherichia coli on haemocytes in Ciona intestinalis // J. Exp. Mar. Biol. Ecol. – 2006. – Vol. 332. – P. 121-134.</mixed-citation><mixed-citation xml:lang="en">Liu L., Wu C., Chen T., Zhang X., Lia F., Luo W., Xiang J. Effects of infection of EGFP-expressing Escherichia coli on haemocytes in Ciona intestinalis // J. Exp. Mar. Biol. Ecol. – 2006. – Vol. 332. – P. 121-134.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Lu X.Y., Wu R.S.S. Ultraviolet damages sperm mitochondrial function and membrane integrity in the sea urchin Anthocidaris crassispina // Ecotoxicol. Environmen. Safety. – 2005. – Vol. 61. – P. 53-59.</mixed-citation><mixed-citation xml:lang="en">Lu X.Y., Wu R.S.S. Ultraviolet damages sperm mitochondrial function and membrane integrity in the sea urchin Anthocidaris crassispina // Ecotoxicol. Environmen. Safety. – 2005. – Vol. 61. – P. 53-59.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Mamali I., Tatari M.N., Micheva I., Lampropoulou M., Marmaras V.J. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling // J. Biol. Chem. – 2007. – Vol. 101. – P. 331-347.</mixed-citation><mixed-citation xml:lang="en">Mamali I., Tatari M.N., Micheva I., Lampropoulou M., Marmaras V.J. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling // J. Biol. Chem. – 2007. – Vol. 101. – P. 331-347.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Maxwell W.M.C., Long C.R., Johnson L.A., Dobrinsky J.R., Welch G.R. The relationship between membrane status and fertility of boar spermatozoa after flow cytometric sorting in the presence or absence of seminal plasma // Reprod. Fertil. Dev. – 1998. – Vol. 10. – P. 433-440.</mixed-citation><mixed-citation xml:lang="en">Maxwell W.M.C., Long C.R., Johnson L.A., Dobrinsky J.R., Welch G.R. The relationship between membrane status and fertility of boar spermatozoa after flow cytometric sorting in the presence or absence of seminal plasma // Reprod. Fertil. Dev. – 1998. – Vol. 10. – P. 433-440.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Micic M., Bihari N., Labura Z., Muller W.E.G., Batel R. Induction of apoptosis in the blue mussel Mytilus galloprovincialis by tri-n-butyltin chloride // Aquatic Toxicol. – 2001. – Vol. 55. – P. 61-73.</mixed-citation><mixed-citation xml:lang="en">Micic M., Bihari N., Labura Z., Muller W.E.G., Batel R. Induction of apoptosis in the blue mussel Mytilus galloprovincialis by tri-n-butyltin chloride // Aquatic Toxicol. – 2001. – Vol. 55. – P. 61-73.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Morga B., Arzul I., Chollet B., Renault T. Infection with the protozoan parasite Bonamia ostreae modifies in vitro haemocyte activities of flat oyster Ostrea edulis // Fish Shellfish Immunol. – 2009. – Vol. 26. – P. 836-842.</mixed-citation><mixed-citation xml:lang="en">Morga B., Arzul I., Chollet B., Renault T. Infection with the protozoan parasite Bonamia ostreae modifies in vitro haemocyte activities of flat oyster Ostrea edulis // Fish Shellfish Immunol. – 2009. – Vol. 26. – P. 836-842.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Nagasaka K., Nakagawa S., Yano T., Takizawa S., Matsumoto Y., Tsuruga T., Nakagawa K., Minaguchi T., Oda K., Hiraike-Wada O., Ooishi H., Yasugi T., Taketani Y. Human homolog of Drosophila tumor suppressor Scribble negatively regulates cellcycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells // Cancer Sci. – 2006. – Vol. 97. – P. 1217-1225.</mixed-citation><mixed-citation xml:lang="en">Nagasaka K., Nakagawa S., Yano T., Takizawa S., Matsumoto Y., Tsuruga T., Nakagawa K., Minaguchi T., Oda K., Hiraike-Wada O., Ooishi H., Yasugi T., Taketani Y. Human homolog of Drosophila tumor suppressor Scribble negatively regulates cellcycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells // Cancer Sci. – 2006. – Vol. 97. – P. 1217-1225.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Orrenius S., Gogvadze V., Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death // Ann. Rev. Pharmacol. Toxicol. – 2007. – Vol. 47. – P. 143-183.</mixed-citation><mixed-citation xml:lang="en">Orrenius S., Gogvadze V., Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death // Ann. Rev. Pharmacol. Toxicol. – 2007. – Vol. 47. – P. 143-183.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Ottaviani E., Barbieri D., Malagoli D., Franchini A. Nitric oxide induces apoptosis in the fat body cell line IPLB-LdFB from the insect Lymantria dispar // Comp. Biochem. Physiol. Part B. – 2001 – Vol.128. – P. 247-254.</mixed-citation><mixed-citation xml:lang="en">Ottaviani E., Barbieri D., Malagoli D., Franchini A. Nitric oxide induces apoptosis in the fat body cell line IPLB-LdFB from the insect Lymantria dispar // Comp. Biochem. Physiol. Part B. – 2001 – Vol.128. – P. 247-254.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Paniagua-Chavez C.G., Jenkins J., Segovia M., Tiersch T.R. Assessment of gamete quality for the eastern oyster (Crassostrea virginica) by use of fluorescent dyes // Cryobiology. – 2006. – Vol. 53. – P. 128-138.</mixed-citation><mixed-citation xml:lang="en">Paniagua-Chavez C.G., Jenkins J., Segovia M., Tiersch T.R. Assessment of gamete quality for the eastern oyster (Crassostrea virginica) by use of fluorescent dyes // Cryobiology. – 2006. – Vol. 53. – P. 128-138.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Pozarowski P., Huang X., Halicka D.H., Lee B., Johnson G., Darzynkiewicz Z. Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation // Cytometry Part A. – 2003. – Vol. 55A. – P. 50-60.</mixed-citation><mixed-citation xml:lang="en">Pozarowski P., Huang X., Halicka D.H., Lee B., Johnson G., Darzynkiewicz Z. Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation // Cytometry Part A. – 2003. – Vol. 55A. – P. 50-60.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Xue Q.-G., Renault T., Chilmonczyk S. Flow cytometric assessment of haemocyte subpopulations in the European flat oyster, Ostrea edulis, haemolymph // Fish Shellfish Immunol. – 2001. – Vol. 11. – P. 557-567.</mixed-citation><mixed-citation xml:lang="en">Xue Q.-G., Renault T., Chilmonczyk S. Flow cytometric assessment of haemocyte subpopulations in the European flat oyster, Ostrea edulis, haemolymph // Fish Shellfish Immunol. – 2001. – Vol. 11. – P. 557-567.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Robertson A.J., Croce J., Carbonneau S., Voronina E., Miranda E., McClay D.R., Coffman J.A. The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus // Dev. Biol. – 2006. – Vol. 300. – P. 321-334.</mixed-citation><mixed-citation xml:lang="en">Robertson A.J., Croce J., Carbonneau S., Voronina E., Miranda E., McClay D.R., Coffman J.A. The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus // Dev. Biol. – 2006. – Vol. 300. – P. 321-334.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Romero A., Estevez-Calvar N., Dios S., Figueras A., Novoa B. New insights into the apoptotic process in mollusks: characterization of caspase genes in Mytilus galloprovincialis // PLoS ONE. – 2011. – Vol. 6,e17003. – P. 1-15.</mixed-citation><mixed-citation xml:lang="en">Romero A., Estevez-Calvar N., Dios S., Figueras A., Novoa B. New insights into the apoptotic process in mollusks: characterization of caspase genes in Mytilus galloprovincialis // PLoS ONE. – 2011. – Vol. 6,e17003. – P. 1-15.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Roy N., Deveraux Q.L., Takahashi R., Salvesen G.S., Reed J.C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases // EMBO J. – 1997. – Vol. 16. – P. 6914-6925.</mixed-citation><mixed-citation xml:lang="en">Roy N., Deveraux Q.L., Takahashi R., Salvesen G.S., Reed J.C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases // EMBO J. – 1997. – Vol. 16. – P. 6914-6925.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Russo J., Madec L. Haemocyte apoptosis as a general cellular immune response of the snail, Lymnaea stagnalis, to a toxicant // Cell Tissue Res. – 2007. – Vol. 328. – P. 431-441.</mixed-citation><mixed-citation xml:lang="en">Russo J., Madec L. Haemocyte apoptosis as a general cellular immune response of the snail, Lymnaea stagnalis, to a toxicant // Cell Tissue Res. – 2007. – Vol. 328. – P. 431-441.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Saha N.R., Suetake H., Kikuchi K., Suzuki Yu. Effects of steroid hormones on apoptosis and IgM production of LPS-stimulated lymphocytes in fugu Takifugu rubripes // Fisheries Science. – 2006. – Vol. 72. – P. 136-142.</mixed-citation><mixed-citation xml:lang="en">Saha N.R., Suetake H., Kikuchi K., Suzuki Yu. Effects of steroid hormones on apoptosis and IgM production of LPS-stimulated lymphocytes in fugu Takifugu rubripes // Fisheries Science. – 2006. – Vol. 72. – P. 136-142.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Saha N.R., Usami T., Suzuki Yu. A double staining flow cytometric assay for the detection of steroid induced apoptotic leucocytes in common carp (Cyprinus carpio) // Dev. Comp. Immunol. – 2003. – Vol. 27. – P. 351-363.</mixed-citation><mixed-citation xml:lang="en">Saha N.R., Usami T., Suzuki Yu. A double staining flow cytometric assay for the detection of steroid induced apoptotic leucocytes in common carp (Cyprinus carpio) // Dev. Comp. Immunol. – 2003. – Vol. 27. – P. 351-363.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Saha N.R., Usami T., Suzuki Yu. In vitro effects of steroid hormones on IgM-secreting cells and IgM secretion in common carp (Cyprinus carpio) // Fish Shellfish Immunol. – 2004. – Vol. 17. – P. 149-158.</mixed-citation><mixed-citation xml:lang="en">Saha N.R., Usami T., Suzuki Yu. In vitro effects of steroid hormones on IgM-secreting cells and IgM secretion in common carp (Cyprinus carpio) // Fish Shellfish Immunol. – 2004. – Vol. 17. – P. 149-158.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Salinas I., Rodrıguez A., Meseguer J., Esteban M.A. Adenosine arrests apoptosis in lymphocytes but not in phagocytes from primary leukocyte cultures of the teleost fish, Sparus aurata L. // Dev. Comp. Immunol. – 2007. – Vol. 31. – P. 1233-1241.</mixed-citation><mixed-citation xml:lang="en">Salinas I., Rodrıguez A., Meseguer J., Esteban M.A. Adenosine arrests apoptosis in lymphocytes but not in phagocytes from primary leukocyte cultures of the teleost fish, Sparus aurata L. // Dev. Comp. Immunol. – 2007. – Vol. 31. – P. 1233-1241.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Verhoven B., Schlegel R.A., Williamson P. Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes // J. Exp. Med. – 1995. – Vol. 182. – P. 1597-1601.</mixed-citation><mixed-citation xml:lang="en">Verhoven B., Schlegel R.A., Williamson P. Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes // J. Exp. Med. – 1995. – Vol. 182. – P. 1597-1601.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Vermes I., Haanen C., Reutelingsperger C. Flow cytometry of apoptotic cell death // J. Immunol. Meth. – 2000. – Vol. 243. – P. 167-190.</mixed-citation><mixed-citation xml:lang="en">Vermes I., Haanen C., Reutelingsperger C. Flow cytometry of apoptotic cell death // J. Immunol. Meth. – 2000. – Vol. 243. – P. 167-190.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Walsh C.M., Edinger A.L. The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis // Immunol. Rev. – 2010. – Vol. 236. – P. 95-109.</mixed-citation><mixed-citation xml:lang="en">Walsh C.M., Edinger A.L. The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis // Immunol. Rev. – 2010. – Vol. 236. – P. 95-109.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Wlodkowic D., Skommer J., Darzynkiewicz Z. Flow cytometry-based apoptosis detection // Meth. Mol. Biol. – 2009. – Vol. 559. – P. 19-32.</mixed-citation><mixed-citation xml:lang="en">Wlodkowic D., Skommer J., Darzynkiewicz Z. Flow cytometry-based apoptosis detection // Meth. Mol. Biol. – 2009. – Vol. 559. – P. 19-32.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Wlodkowic D., Telford W., Skommer J., Darzynkiewicz Z. Apoptosis and beyond: cytometry in studies of programmed cell death // Methods in Cell Biology. – 2011. – Vol. 103. – P. 55-98.</mixed-citation><mixed-citation xml:lang="en">Wlodkowic D., Telford W., Skommer J., Darzynkiewicz Z. Apoptosis and beyond: cytometry in studies of programmed cell death // Methods in Cell Biology. – 2011. – Vol. 103. – P. 55-98.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Wohllebe S., Ulbrich C., Grimm D., Pietsch J., Erzinger G., Richter R., Lebert M., Richter P.R., Hader D.P. Photodynamic treatment of Chaoborus crystallinus larvae with chlorophyllin induces necrosis and apoptosis // Photochem Photobiol. – 2011. – Vol. 87. – P. 1113-1122.</mixed-citation><mixed-citation xml:lang="en">Wohllebe S., Ulbrich C., Grimm D., Pietsch J., Erzinger G., Richter R., Lebert M., Richter P.R., Hader D.P. Photodynamic treatment of Chaoborus crystallinus larvae with chlorophyllin induces necrosis and apoptosis // Photochem Photobiol. – 2011. – Vol. 87. – P. 1113-1122.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Xiang L., Peng B., Dong W., Yang Z., Shao J. Lipopolysaccharide induces apoptosis in Carassius auratus lymphocytes, a possible role in pathogenesis of bacterial infection in fish // Dev. Comp. Immunol. – 2008. – Vol. 32. – P. 992-1001.</mixed-citation><mixed-citation xml:lang="en">Xiang L., Peng B., Dong W., Yang Z., Shao J. Lipopolysaccharide induces apoptosis in Carassius auratus lymphocytes, a possible role in pathogenesis of bacterial infection in fish // Dev. Comp. Immunol. – 2008. – Vol. 32. – P. 992-1001.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H., Zhang J., Zhu Y. In vitro investigations for the QSAR mechanism of lymphocytes apoptosis induced by substituted aromatic toxicants // Fish Shellfish Immunol. – 2008. – Vol. 25. – P. 710-717.</mixed-citation><mixed-citation xml:lang="en">Zhang H., Zhang J., Zhu Y. In vitro investigations for the QSAR mechanism of lymphocytes apoptosis induced by substituted aromatic toxicants // Fish Shellfish Immunol. – 2008. – Vol. 25. – P. 710-717.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang L., Li L., Zhang G. Gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system // Dev. Comp. Immunol. – 2011. – Vol. 35. – P. 603-610.</mixed-citation><mixed-citation xml:lang="en">Zhang L., Li L., Zhang G. Gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system // Dev. Comp. Immunol. – 2011. – Vol. 35. – P. 603-610.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Zhivotovsky B, Orrenius S. Current concepts in cell death // Curr. Protoc. Cell Biol. – 2001. – Chapter 18. – Unit 18.1.</mixed-citation><mixed-citation xml:lang="en">Zhivotovsky B, Orrenius S. Current concepts in cell death // Curr. Protoc. Cell Biol. – 2001. – Chapter 18. – Unit 18.1.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Zhivotovsky B. Apoptosis, necrosis and between // Cell Cycle. – 2004. – Vol. 3. – P. 64-66.</mixed-citation><mixed-citation xml:lang="en">Zhivotovsky B. Apoptosis, necrosis and between // Cell Cycle. – 2004. – Vol. 3. – P. 64-66.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
