mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2011-2-3-121-132mimmun-520Research ArticleОБЗОРЫREVIEWSТОЛЕРАНТНОСТЬ МАТЕРИ И ПЛОДА КАК ПРОЯВЛЕНИЕ РЕГУЛЯТОРНОГО КОНТИНУУМА И ПЛАСТИЧНОСТИ ИХ ИММУННЫХ СИСТЕМ(Посвящается памяти И.П. Ашмарина)MATERNAL-FETAL TOLERANCE AS A MANIFESTATION OF REGULATORY CONTINUUM AND PLASTICITY OF THEIR IMMUNE SYSTEMS (in memory of I.P. Ashmarin)ХарченкоЕ. П.KharchenkoE. P.

198013, Санкт-Петербург, Московский пр., 20, кв. 55.

kharchen@iephb.ruУчреждение Российской академии наук Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН, Санкт-ПетербургРоссия201122072014132-3121132Copyright © Харченко Е.П., 20142014Харченко Е.П.Kharchenko E.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/520

Резюме. Рассматривается толерантность иммунных систем матери и плода в аспекте общего регуляторного континуума, формирующегося во время беременности под влиянием растущего плода. Для  объяснения  толерантности  вводится  понятие  пластичности  иммунной  системы,  аналогичной нервной системе и реагирующей на девятимесячный континуум изменений, происходящих в плоде и в самом женском организме, последовательно адаптируя все его системы. Пластичность иммунной системы женского организма предполагается как одна из возможных причин коллизий зачатия и протекания беременности.

Abstract. Relations of immune tolerance between mother and fetus are considered in view of a common regulatory continuum which is formed under the influence of a growing fetus. To explain such an immune tolerance, a notion of immune system plasticity is introduced, as an analogue to the nervous system plasticity, which develops in response to a continuum of changes occurring in fetal and maternal organisms during the nine months of pregnancy. The immune system plasticity in females is supposed to be among possible factors causing collisions upon conception and in the course of pregnancy. (Med. Immunol., 2011, vol. 13, N 2-3, pp 121-132)

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The authors declare that there are no conflicts of interest present.