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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2010-1-2-115-124</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-52</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ПОЛНОРАЗМЕРНЫЙ ПЕПТИДНЫЙ АНАЛИЗ АНТИГЕННОГО ПРОФИЛЯ ПОВЕРХНОСТНЫХ БЕЛКОВ СИБИРСКИХ ИЗОЛЯТОВ ВИРУСА ГЕПАТИТА C</article-title><trans-title-group xml:lang="en"><trans-title>FULL-LENGTH PEPTIDE ASSAY OF ANTIGENIC PROFILE OF ENVELOPE PROTEINS FROM SIBERIAN ISOLATES OF HEPATITIS C VIRUS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гражданцева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grazhdantseva</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сиволобова</surname><given-names>Г. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivolobova</surname><given-names>G. F.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Major</surname><given-names>M.</given-names></name><name name-style="western" xml:lang="en"><surname>Major</surname><given-names>M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чуб</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chub</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Швалов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shvalov</surname><given-names>A. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдин</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudin</surname><given-names>P. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нетесов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Netesov</surname><given-names>S. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Локтев</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Loktev</surname><given-names>V. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кочнева</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kochneva</surname><given-names>G. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГУН Государственный научный центр вирусологии и биотехнологии «Вектор» Роспотребнадзора,&#13;
Новосибирская обл., г. Кольцово<country>Россия</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Центр по оценке и исследованиям биологических препаратов, Управление по контролю за пищевыми продуктами и лекарственными средствами США, Мэриленд, г. Бетезда<country>Россия</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГУН Государственный научный центр вирусологии и биотехнологии «Вектор» Роспотребнадзора,&#13;
Новосибирская обл., г. Кольцово&#13;
ГОУ ВПО «Новосибирский государственный университет», г. Новосибирск<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>10</day><month>07</month><year>2014</year></pub-date><volume>12</volume><issue>1-2</issue><fpage>115</fpage><lpage>124</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гражданцева А.А., Сиволобова Г.Ф., Major M., Чуб Е.В., Швалов А.Н., Юдин П.В., Нетесов С.В., Локтев В.Б., Кочнева Г.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Гражданцева А.А., Сиволобова Г.Ф., Major M., Чуб Е.В., Швалов А.Н., Юдин П.В., Нетесов С.В., Локтев В.Б., Кочнева Г.В.</copyright-holder><copyright-holder xml:lang="en">Grazhdantseva A.A., Sivolobova G.F., Major M., Chub E.V., Shvalov A.N., Yudin P.V., Netesov S.V., Loktev V.B., Kochneva G.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/52">https://www.mimmun.ru/mimmun/article/view/52</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>вирус гепатита С</kwd><kwd>генотип</kwd><kwd>пептидный анализ</kwd><kwd>антигенная детерминанта</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hepatitis C virus</kwd><kwd>genоtype</kwd><kwd>peptide analysis</kwd><kwd>antigenic determinant</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шустов А.В., Кочнева Г.В., Сиволобова Г.Ф., Гражданцева А.А., Гаврилова И.В., Нестеров А.Е., Стрельцова М.А., Пальцев А.И., Локтев А.В., Максютов А.З., Акинфеева Л.А., Торшин В.П., West T.E., Ryder R.W., Онищенко Г.Г. Частота встречаемости маркеров гепатита С и факторы риска у персонала больниц Новосибирской области // Журн. микробиол. эпидемиол. и иммунобиологии (ЖМЭИ). -2002. -T. 2. - C. 26-32.</mixed-citation><mixed-citation xml:lang="en">Шустов А.В., Кочнева Г.В., Сиволобова Г.Ф., Гражданцева А.А., Гаврилова И.В., Нестеров А.Е., Стрельцова М.А., Пальцев А.И., Локтев А.В., Максютов А.З., Акинфеева Л.А., Торшин В.П., West T.E., Ryder R.W., Онищенко Г.Г. Частота встречаемости маркеров гепатита С и факторы риска у персонала больниц Новосибирской области // Журн. микробиол. эпидемиол. и иммунобиологии (ЖМЭИ). -2002. -T. 2. - C. 26-32.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bowen D.G., Walker C.M. Adaptive immune responses in acute and chronic hepatitis C virus infection // Nature. -2005. -Vol. 436. -P. 946-952.</mixed-citation><mixed-citation xml:lang="en">Bowen D.G., Walker C.M. Adaptive immune responses in acute and chronic hepatitis C virus infection // Nature. -2005. -Vol. 436. -P. 946-952.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bukh J., Miller R.H., Purcell R.H. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes // Semin Liver Dis. -1995. -Vol. 15. -P. 41-63.</mixed-citation><mixed-citation xml:lang="en">Bukh J., Miller R.H., Purcell R.H. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes // Semin Liver Dis. -1995. -Vol. 15. -P. 41-63.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Carlos M.P., Yamamura Y., Vu Q., Conzen K., Anderson D.E., Torres J.V. Humoral immunity to immunodominant epitopes of Hepatitis C virus in individuals infected with genotypes 1a or 1b // Clin. Immunol. -2004. -Vol. 111. -P. 22-27.</mixed-citation><mixed-citation xml:lang="en">Carlos M.P., Yamamura Y., Vu Q., Conzen K., Anderson D.E., Torres J.V. Humoral immunity to immunodominant epitopes of Hepatitis C virus in individuals infected with genotypes 1a or 1b // Clin. Immunol. -2004. -Vol. 111. -P. 22-27.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Farci P., Shimoda A., Wong D., Cabezon T., De Gioannis D., Strazzera A., Shimizu Y., Shapiro M., Alter H., Purcell R. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein // Proc. Natl. Acad. Sci. USA. -1996. -Vol. 93. -P. 15394-15399.</mixed-citation><mixed-citation xml:lang="en">Farci P., Shimoda A., Wong D., Cabezon T., De Gioannis D., Strazzera A., Shimizu Y., Shapiro M., Alter H., Purcell R. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein // Proc. Natl. Acad. Sci. USA. -1996. -Vol. 93. -P. 15394-15399.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gotto J., Dusheiko G.M. Hepatitis C and treatment with pegylated interferon and ribavirin // Int. J. Biochem. Cell Biol. -2004. -Vol. 36, N 10. -P. 1874-1877.</mixed-citation><mixed-citation xml:lang="en">Gotto J., Dusheiko G.M. Hepatitis C and treatment with pegylated interferon and ribavirin // Int. J. Biochem. Cell Biol. -2004. -Vol. 36, N 10. -P. 1874-1877.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ishida C., Matsumoto K., Fukada K., Matsushita K., Shiraki H., Maeda Y. Detection of antibodies to hepatitis C virus (HCV) structural proteins in anti-HCV-positive sera by an enzyme-linked immunosorbent assay using synthetic peptides as antigens // J. Clin. Microbiol. -1993. -Vol. 31. -P. 936-940.</mixed-citation><mixed-citation xml:lang="en">Ishida C., Matsumoto K., Fukada K., Matsushita K., Shiraki H., Maeda Y. Detection of antibodies to hepatitis C virus (HCV) structural proteins in anti-HCV-positive sera by an enzyme-linked immunosorbent assay using synthetic peptides as antigens // J. Clin. Microbiol. -1993. -Vol. 31. -P. 936-940.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Keck Z-Y., Sung V.M.H., Perkins S., Rowe J., Paul S., Liang T.J., Lai M.M.C., Foung S.K.H. Human monoclonal antibody to hepatitis C Virus E1 glycoprotein that blocks virus attachment and viral infectivity//J. Virol. -2004. -Vol. 78, N 13. -P. 7257-7263.</mixed-citation><mixed-citation xml:lang="en">Keck Z-Y., Sung V.M.H., Perkins S., Rowe J., Paul S., Liang T.J., Lai M.M.C., Foung S.K.H. Human monoclonal antibody to hepatitis C Virus E1 glycoprotein that blocks virus attachment and viral infectivity//J. Virol. -2004. -Vol. 78, N 13. -P. 7257-7263.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lecnmann M., Ihlenfeldt H.G., Braunschweiger I., Gierls G., Jung G., Matz B., Kaiser R., Sauberbruch T., Spengler U. T and B Cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia // Hepatology. -1996. -Vol. 24, N 4. -P. 790-795.</mixed-citation><mixed-citation xml:lang="en">Lecnmann M., Ihlenfeldt H.G., Braunschweiger I., Gierls G., Jung G., Matz B., Kaiser R., Sauberbruch T., Spengler U. T and B Cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia // Hepatology. -1996. -Vol. 24, N 4. -P. 790-795.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Donato G., Duenas-Carrera S., Alvarez-Lajonchere L., Morales J., Acosta-Rivero N., Martínez E., Viña A., Guerra I., Prez A., Musacchio A., García J., Reyes O., Garay H.E., González L.J., Alvarez J.C., Soria Y. Antigenicity and immunogenecity of the hepatitis C virus envelope E2 protein // Biotecnologia Aplicada. -2006. -Vol. 23, N 1. -P. 60-63.</mixed-citation><mixed-citation xml:lang="en">Martinez-Donato G., Duenas-Carrera S., Alvarez-Lajonchere L., Morales J., Acosta-Rivero N., Martínez E., Viña A., Guerra I., Prez A., Musacchio A., García J., Reyes O., Garay H.E., González L.J., Alvarez J.C., Soria Y. Antigenicity and immunogenecity of the hepatitis C virus envelope E2 protein // Biotecnologia Aplicada. -2006. -Vol. 23, N 1. -P. 60-63.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Meunier J.C., Russell R.S., Goossens V., Priem S., Walter H., Depla E., Union A., Faulk K.N., Bukh J., Emerson S.U., Purcell R.H. Isolation and characterization of broadly neutralizing human monoclonal antibodies to the E1 glycoprotein of hepatitis C virus // J. Virol. -2008. -Vol. 82, N 2. -P. 966-973.</mixed-citation><mixed-citation xml:lang="en">Meunier J.C., Russell R.S., Goossens V., Priem S., Walter H., Depla E., Union A., Faulk K.N., Bukh J., Emerson S.U., Purcell R.H. Isolation and characterization of broadly neutralizing human monoclonal antibodies to the E1 glycoprotein of hepatitis C virus // J. Virol. -2008. -Vol. 82, N 2. -P. 966-973.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Olenina L.V., Nikolaeva L.I., Sobolev B.N., Blokhina N.P., Archakov A.I., Kolesanova E.F. Mapping and characterization of B cell linear epitopes in the conservative regions of hepatitis C virus envelope glycoproteins // J. Viral. Hepat. -2002. -Vol. 9. -P. 174-182.</mixed-citation><mixed-citation xml:lang="en">Olenina L.V., Nikolaeva L.I., Sobolev B.N., Blokhina N.P., Archakov A.I., Kolesanova E.F. Mapping and characterization of B cell linear epitopes in the conservative regions of hepatitis C virus envelope glycoproteins // J. Viral. Hepat. -2002. -Vol. 9. -P. 174-182.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Perotti M., Mancini N., Diotti R.A., Tarr A.W., Ball J.K., Owsianka A., Adair R., Patel A.H., Clementi M., Burioni R. Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein // J. Virol. -2008. -Vol. 82, N 2. - P. 1047-1052.</mixed-citation><mixed-citation xml:lang="en">Perotti M., Mancini N., Diotti R.A., Tarr A.W., Ball J.K., Owsianka A., Adair R., Patel A.H., Clementi M., Burioni R. Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein // J. Virol. -2008. -Vol. 82, N 2. - P. 1047-1052.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Petit M.-A., Jolivet-Reynaud C., Peronnet E., Michal Y., Tre'po C. Mapping of a conformational epitope shared between E1 and E2 on the serum-derived human hepatitis C virus envelope // J. Biol. Chem. -2003. -Vol. 278, N 45. -P. 44385-44392.</mixed-citation><mixed-citation xml:lang="en">Petit M.-A., Jolivet-Reynaud C., Peronnet E., Michal Y., Tre'po C. Mapping of a conformational epitope shared between E1 and E2 on the serum-derived human hepatitis C virus envelope // J. Biol. Chem. -2003. -Vol. 278, N 45. -P. 44385-44392.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Petrik J., Alexander G.J.M., Pearson G., Allain J.P. Reactivity of synthetic peptides representing selected sections of hepatitis C virus Core and envelope proteins with a panel of hepatitis C virus-seropositive human plasma//J. Med. Virol. -1997. -Vol. 51. -P. 67-79.</mixed-citation><mixed-citation xml:lang="en">Petrik J., Alexander G.J.M., Pearson G., Allain J.P. Reactivity of synthetic peptides representing selected sections of hepatitis C virus Core and envelope proteins with a panel of hepatitis C virus-seropositive human plasma//J. Med. Virol. -1997. -Vol. 51. -P. 67-79.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sallberg M., Ruden U., Wahren B., Magnius L.O. Antigenic regions within the hepatitis C virus envelope 1 and structural proteins: identification of an IgG3-restricted recognition site within the envelope 1 protein // Clin. Exp. Imunol. -1993. -Vol. 91. -P. 489-494.</mixed-citation><mixed-citation xml:lang="en">Sallberg M., Ruden U., Wahren B., Magnius L.O. Antigenic regions within the hepatitis C virus envelope 1 and structural proteins: identification of an IgG3-restricted recognition site within the envelope 1 protein // Clin. Exp. Imunol. -1993. -Vol. 91. -P. 489-494.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Seeff L.B. Natural history of chronic hepatitis C // Hepatology. -2002. -Vol. 36, N 5. - P. 35-46.</mixed-citation><mixed-citation xml:lang="en">Seeff L.B. Natural history of chronic hepatitis C // Hepatology. -2002. -Vol. 36, N 5. - P. 35-46.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Shimizu Y.K., Igarashi H., Kiyohara T. A hyperimmune constructs against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures // Virol. -1996. -Vol. 223. -P. 409-412.</mixed-citation><mixed-citation xml:lang="en">Shimizu Y.K., Igarashi H., Kiyohara T. A hyperimmune constructs against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures // Virol. -1996. -Vol. 223. -P. 409-412.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Simmonds P., Rose K.A., Graham S., Chan S.W., McOmish F., Dow B.C., Follet E.A., Yap P.L., Marsden H. Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3 // J. Clin. Microbiol. -1993. -Vol. 31. -P. 1493-1503.</mixed-citation><mixed-citation xml:lang="en">Simmonds P., Rose K.A., Graham S., Chan S.W., McOmish F., Dow B.C., Follet E.A., Yap P.L., Marsden H. Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3 // J. Clin. Microbiol. -1993. -Vol. 31. -P. 1493-1503.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Simmonds P. The origin and evolution of hepatitis viruses in humans // J. Gen. Virol. -2001. -Vol. 82. -P. 693-712.</mixed-citation><mixed-citation xml:lang="en">Simmonds P. The origin and evolution of hepatitis viruses in humans // J. Gen. Virol. -2001. -Vol. 82. -P. 693-712.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Tarr A.W., Owsianka A.M., Timms J.M., Patrick McClure C., Brown R.J.P., Hickling T.P., Pietschmann T., Bartenschlager R., Patel A.H., Ball J.K. Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33 // Hepatology. -2006. -Vol. 43, N 3. -P. 592-601.</mixed-citation><mixed-citation xml:lang="en">Tarr A.W., Owsianka A.M., Timms J.M., Patrick McClure C., Brown R.J.P., Hickling T.P., Pietschmann T., Bartenschlager R., Patel A.H., Ball J.K. Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33 // Hepatology. -2006. -Vol. 43, N 3. -P. 592-601.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Tarr A.W., Owsianka A.M., Szwejk A., Ball J.K., Patel A.H. Cloning, expression and functional analysis of patient-derived hepatitis C virus glycoproteins // Methods Mol. Biol. -2007. -Vol. 379. -P. 177-197.</mixed-citation><mixed-citation xml:lang="en">Tarr A.W., Owsianka A.M., Szwejk A., Ball J.K., Patel A.H. Cloning, expression and functional analysis of patient-derived hepatitis C virus glycoproteins // Methods Mol. Biol. -2007. -Vol. 379. -P. 177-197.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tarr A.W., Owsianka A.M., Jayaraj D., Brown R.J.P., Hickling T.P., Irving W.L., Patel A.H., Ball J.K. Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33 // J. Gen. Virol. -2007. -Vol. 88. -Р. 2991-3001.</mixed-citation><mixed-citation xml:lang="en">Tarr A.W., Owsianka A.M., Jayaraj D., Brown R.J.P., Hickling T.P., Irving W.L., Patel A.H., Ball J.K. Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33 // J. Gen. Virol. -2007. -Vol. 88. -Р. 2991-3001.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Z.-X., Sonnerborg A., Sallberg M. Antigenic structure of the hepatitis C virus envelope 2 protein // Clin. Exp. Immunol. -1994. -Vol. 98. -P. 382-387.</mixed-citation><mixed-citation xml:lang="en">Zhang Z.-X., Sonnerborg A., Sallberg M. Antigenic structure of the hepatitis C virus envelope 2 protein // Clin. Exp. Immunol. -1994. -Vol. 98. -P. 382-387.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Zang P., Wu C.G., Mihalik K., Virata-Theimer M.L., Yu M.W., Alter H.J., Feinstone S.M. Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma // Proc. Natl. Acad. Sci. USA. -2007. -Vol. 104, N 20. -P. 8449-8454.</mixed-citation><mixed-citation xml:lang="en">Zang P., Wu C.G., Mihalik K., Virata-Theimer M.L., Yu M.W., Alter H.J., Feinstone S.M. Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma // Proc. Natl. Acad. Sci. USA. -2007. -Vol. 104, N 20. -P. 8449-8454.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang P., Zhong L., Struble E. B., Watanabe H., Kachko A., Mihalik K., Virata-Theimer M.L., Alter H.J., Feinstone S., Major M. Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity // Proc. Natl. Acad. Sci. USA. -2009. -Vol. 106, N 18. -P. 537-541.</mixed-citation><mixed-citation xml:lang="en">Zhang P., Zhong L., Struble E. B., Watanabe H., Kachko A., Mihalik K., Virata-Theimer M.L., Alter H.J., Feinstone S., Major M. Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity // Proc. Natl. Acad. Sci. USA. -2009. -Vol. 106, N 18. -P. 537-541.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
