<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2010-1-2-95-102</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-50</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ ПОЛИМОРФИЗМА ГЕНА CD14 НА ТЕЧЕНИЕ И ИСХОД НОЗОКОМИАЛЬНОЙ ПНЕВМОНИИ</article-title><trans-title-group xml:lang="en"><trans-title>INFLUENCE OF CD14 GENE POLYMORHISM ON CLINIC AL COURSE AND OUTCOME OF NOSOCOMIAL PNEUMONIA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байгозина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baygozina</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">pulmonology55@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Совалкин</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sovalkin</surname><given-names>V. I.</given-names></name></name-alternatives><email xlink:type="simple">pulmonology55@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Областная клиническая больница, г. Омск<country>Россия</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Омская государственная медицинская академия, г. Омск<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>10</day><month>07</month><year>2014</year></pub-date><volume>12</volume><issue>1-2</issue><fpage>95</fpage><lpage>102</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Байгозина Е.А., Совалкин В.И., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Байгозина Е.А., Совалкин В.И.</copyright-holder><copyright-holder xml:lang="en">Baygozina E.A., Sovalkin V.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/50">https://www.mimmun.ru/mimmun/article/view/50</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>полиморфизм</kwd><kwd>ген</kwd><kwd>CD14</kwd><kwd>нозокомиальная пневмония</kwd></kwd-group><kwd-group xml:lang="en"><kwd>polymorphism</kwd><kwd>gene</kwd><kwd>CD14</kwd><kwd>nosocomial pneumonia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Симбирцев А.С., Громова А.Ю. Функциональный полиморфизм генов регуляторных молекул воспаления// Цитокины и воспаление. -2005. -Т. 4, № 1. -С. 3-10.</mixed-citation><mixed-citation xml:lang="en">Симбирцев А.С., Громова А.Ю. Функциональный полиморфизм генов регуляторных молекул воспаления// Цитокины и воспаление. -2005. -Т. 4, № 1. -С. 3-10.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Agnese D.M., Calvano J.E., Hahm S.J. Human toll-like receptor 4 mutation but not CD14 polymorphisms are associated with an increased risk of gram-negative infections// J. Infect. Dis. -2002. -Vol. 186. -P. 1522-1525.</mixed-citation><mixed-citation xml:lang="en">Agnese D.M., Calvano J.E., Hahm S.J. Human toll-like receptor 4 mutation but not CD14 polymorphisms are associated with an increased risk of gram-negative infections// J. Infect. Dis. -2002. -Vol. 186. -P. 1522-1525.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Antal-Szalmas P., van Strijp J.A.G., Weersink A.J.L., Verhoef J., van Kessel K.P.M. Quantitation of surface CD14 on human monocytes and neutrophils// J. Leukoc. Biol. -1997. - Vol. 62. -P. 721-728.</mixed-citation><mixed-citation xml:lang="en">Antal-Szalmas P., van Strijp J.A.G., Weersink A.J.L., Verhoef J., van Kessel K.P.M. Quantitation of surface CD14 on human monocytes and neutrophils// J. Leukoc. Biol. -1997. - Vol. 62. -P. 721-728.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Arcaroli J., Fessler M.B., Abraham E. Genetic polymorphisms and sepsis// Shock. -2005. -Vol. 24, N 4. -P. 300-312.</mixed-citation><mixed-citation xml:lang="en">Arcaroli J., Fessler M.B., Abraham E. Genetic polymorphisms and sepsis// Shock. -2005. -Vol. 24, N 4. -P. 300-312.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Von Aulock S., Rupp J., Gueinzius K., Maass M., Hermann C. Critical investigation of the CD14 promoter polymorphism: lack of a role for in vitro cytokine response and membrane CD14 expression// Clinical and Diagnostic Laboratory Immunology. -2005. -Vol. 12, N 10. -P. 1254-1256.</mixed-citation><mixed-citation xml:lang="en">Von Aulock S., Rupp J., Gueinzius K., Maass M., Hermann C. Critical investigation of the CD14 promoter polymorphism: lack of a role for in vitro cytokine response and membrane CD14 expression// Clinical and Diagnostic Laboratory Immunology. -2005. -Vol. 12, N 10. -P. 1254-1256.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Barber R.C., Chang L.Y.E., Arnoldo B.D., Purdue G.F., Hunt J.L., Horton J.W., Aragaki C.C. Innate immunity SNPs are associated with risk for severe sepsis after burn injury// Clinical Medicine. -2006. -Vol. 4, N 4. -P. 250-255.</mixed-citation><mixed-citation xml:lang="en">Barber R.C., Chang L.Y.E., Arnoldo B.D., Purdue G.F., Hunt J.L., Horton J.W., Aragaki C.C. Innate immunity SNPs are associated with risk for severe sepsis after burn injury// Clinical Medicine. -2006. -Vol. 4, N 4. -P. 250-255.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ebong S.J., Goyert S.M., Nemzek J.A., Kim J., Bolgos G.L., Remick D. Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality// Infection and Immunity. -2001. -P. 2099-2106.</mixed-citation><mixed-citation xml:lang="en">Ebong S.J., Goyert S.M., Nemzek J.A., Kim J., Bolgos G.L., Remick D. Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality// Infection and Immunity. -2001. -P. 2099-2106.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Eng H.L., Chen C.H., Kuo C.C., Wu J.S., Wang C.H., Lin T.M. Association of CD14 promoter gene polymorphism and Chlamydia pneumoniae infectio// J. Infect. Dis. -2003. -Vol. 188. -P. 90-97.</mixed-citation><mixed-citation xml:lang="en">Eng H.L., Chen C.H., Kuo C.C., Wu J.S., Wang C.H., Lin T.M. Association of CD14 promoter gene polymorphism and Chlamydia pneumoniae infectio// J. Infect. Dis. -2003. -Vol. 188. -P. 90-97.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Eng H.L., Wang C.H., Chen C.H., Chou M.H., Cheng C.T., Lin T.M. A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia -stimulated TNF alpha production// Genes Immun. -2004. -Vol. 5. -P. 426-430.</mixed-citation><mixed-citation xml:lang="en">Eng H.L., Wang C.H., Chen C.H., Chou M.H., Cheng C.T., Lin T.M. A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia -stimulated TNF alpha production// Genes Immun. -2004. -Vol. 5. -P. 426-430.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrero E., Jiao D., Tsuberi B.Z., Tesio L., Wei Rong G., Haziot A. Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide// Proc. Natl. Acad. Sci. USA. -1993. -Vol. 90. -P. 2380-2384.</mixed-citation><mixed-citation xml:lang="en">Ferrero E., Jiao D., Tsuberi B.Z., Tesio L., Wei Rong G., Haziot A. Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide// Proc. Natl. Acad. Sci. USA. -1993. -Vol. 90. -P. 2380-2384.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gibot S., Cariou A., Drouet L., Rossignol M., Ripoll L. Association between a genomic polymorphism within the CD 14 locus and septic shock susceptibility and mortality rate// Crit. Care Med. -2002. -Vol. 30. -P. 969-973.</mixed-citation><mixed-citation xml:lang="en">Gibot S., Cariou A., Drouet L., Rossignol M., Ripoll L. Association between a genomic polymorphism within the CD 14 locus and septic shock susceptibility and mortality rate// Crit. Care Med. -2002. -Vol. 30. -P. 969-973.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Haziot A., Ferrero E., Kntgen F., Hijiya N., Yamamoto S., Silver J., Stewart C.L., Goyert S.M. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria on CD14-deficient mice// Immunity. -1996. - Vol. 4. -P. 407-414.</mixed-citation><mixed-citation xml:lang="en">Haziot A., Ferrero E., Kntgen F., Hijiya N., Yamamoto S., Silver J., Stewart C.L., Goyert S.M. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria on CD14-deficient mice// Immunity. -1996. - Vol. 4. -P. 407-414.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Haziot A., Hijiya N., Schultz K., Zhang F., Gangloff S.C., Goyert S.M. CD14 plays no major role in shock induced by Staphylococcus aureus but down-regulates TNF-alpha production// J. Immunol. -1999. -Vol. 162. -P. 4801-4805.</mixed-citation><mixed-citation xml:lang="en">Haziot A., Hijiya N., Schultz K., Zhang F., Gangloff S.C., Goyert S.M. CD14 plays no major role in shock induced by Staphylococcus aureus but down-regulates TNF-alpha production// J. Immunol. -1999. -Vol. 162. -P. 4801-4805.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Heesen M., Blomeke B., Schluter B., Heussen N., Rossaint R., Kunz D. Lack of association between the -260 C→T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels// Intens. Care Med. -2001. -Vol. 27. -P. 1770-1775.</mixed-citation><mixed-citation xml:lang="en">Heesen M., Blomeke B., Schluter B., Heussen N., Rossaint R., Kunz D. Lack of association between the -260 C→T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels// Intens. Care Med. -2001. -Vol. 27. -P. 1770-1775.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Heesen M., Bloemeke B., Schade U., Obertacke U., Majetschak M. The -260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients// Intensive Care Med. -2002. -Vol. 28. -P. 1161-1163.</mixed-citation><mixed-citation xml:lang="en">Heesen M., Bloemeke B., Schade U., Obertacke U., Majetschak M. The -260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients// Intensive Care Med. -2002. -Vol. 28. -P. 1161-1163.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hoshido K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., Akira S. Cutting edge: toll-like receptor 4 (TLR4) -deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product// J. Immunol. -1999. -Vol. 162. -P. 3749-3752.</mixed-citation><mixed-citation xml:lang="en">Hoshido K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., Akira S. Cutting edge: toll-like receptor 4 (TLR4) -deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product// J. Immunol. -1999. -Vol. 162. -P. 3749-3752.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hubacek J.A., Pit’ha J., Skodova Z., Stanek V., Poledne R. C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction// Circulation. -1999. -Vol. 99. -P. 3218-3220.</mixed-citation><mixed-citation xml:lang="en">Hubacek J.A., Pit’ha J., Skodova Z., Stanek V., Poledne R. C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction// Circulation. -1999. -Vol. 99. -P. 3218-3220.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hubacek J.A., Stuber F., Frohlich D. The common functional C(-159)→T polymorphism wihin the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality// Genes. Immun. -2000. -Vol. 1. -P. 405-407.</mixed-citation><mixed-citation xml:lang="en">Hubacek J.A., Stuber F., Frohlich D. The common functional C(-159)→T polymorphism wihin the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality// Genes. Immun. -2000. -Vol. 1. -P. 405-407.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ito D., Murata M., Tanahashi N. Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease// Stroke. -2000. -Vol. 31. -P. 2661-2664.</mixed-citation><mixed-citation xml:lang="en">Ito D., Murata M., Tanahashi N. Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease// Stroke. -2000. -Vol. 31. -P. 2661-2664.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kitchens R.L., Thompson P.A., Viriyakosol S., O’Keefe G.E., Munford R.S. Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins// J. Clin. Invest. -2001. -Vol. 108. -P. 485-493.</mixed-citation><mixed-citation xml:lang="en">Kitchens R.L., Thompson P.A., Viriyakosol S., O’Keefe G.E., Munford R.S. Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins// J. Clin. Invest. -2001. -Vol. 108. -P. 485-493.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kondo T., Ohno M., Shimokata K., Iino S., Inden Y., Murohara T., Hirai M. CD14 promoter polymorphism is associated with acute myocardial infarction resulting from insignificant coronary artery stenosis// Heart. -2003. -Vol. 89. -P. 931-932.</mixed-citation><mixed-citation xml:lang="en">Kondo T., Ohno M., Shimokata K., Iino S., Inden Y., Murohara T., Hirai M. CD14 promoter polymorphism is associated with acute myocardial infarction resulting from insignificant coronary artery stenosis// Heart. -2003. -Vol. 89. -P. 931-932.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Linden M.W., Huizinga T.W., Stoeken D.J., Sturk A., Westendorp R.G. Determination of tumor necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation// J. Immunol. Methods. -1998. -Vol. 218. -P. 63-71.</mixed-citation><mixed-citation xml:lang="en">Van der Linden M.W., Huizinga T.W., Stoeken D.J., Sturk A., Westendorp R.G. Determination of tumor necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation// J. Immunol. Methods. -1998. -Vol. 218. -P. 63-71.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Netea M.G., Galama J.M.D., Kullberg B.J., Stalenhoef A.F.H., Dinarello C.A., Van der Meer J.W.M. Non -LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways// Eur. J. Immunol. -2002. -Vol. 32. -P. 1188-1195.</mixed-citation><mixed-citation xml:lang="en">Netea M.G., Galama J.M.D., Kullberg B.J., Stalenhoef A.F.H., Dinarello C.A., Van der Meer J.W.M. Non -LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways// Eur. J. Immunol. -2002. -Vol. 32. -P. 1188-1195.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Poltorak A., Ricciardi-Castagnoli P., Citterio S., Beutler B. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation// Proc. Natl. Acad. Sci. USA. -2000. -Vol. 97. -P. 2163-2167.</mixed-citation><mixed-citation xml:lang="en">Poltorak A., Ricciardi-Castagnoli P., Citterio S., Beutler B. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation// Proc. Natl. Acad. Sci. USA. -2000. -Vol. 97. -P. 2163-2167.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Da Silva Correia J., Soldau K., Christen U., Tobias P.S., Ulevitch R.J. Lipopolysaccharide is in close proximity to each of the protein in its membrane receptor complex: transfer from CD14 to TLR4 and MD2// J. Biol. Chem. -2001. -Vol. 276. - P. 21129-21135.</mixed-citation><mixed-citation xml:lang="en">Da Silva Correia J., Soldau K., Christen U., Tobias P.S., Ulevitch R.J. Lipopolysaccharide is in close proximity to each of the protein in its membrane receptor complex: transfer from CD14 to TLR4 and MD2// J. Biol. Chem. -2001. -Vol. 276. - P. 21129-21135.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Temple S.E.L., Cheong K.Y., Almeida C.M., Price P., Waterer G.W. Polymorphisms in lymphotoxin alpha and CD14 genes influence TNFα production induced by gram-positive and gram-negative bacteria// Genes and Immunity. -2003. -Vol. 4. -P. 283-288.</mixed-citation><mixed-citation xml:lang="en">Temple S.E.L., Cheong K.Y., Almeida C.M., Price P., Waterer G.W. Polymorphisms in lymphotoxin alpha and CD14 genes influence TNFα production induced by gram-positive and gram-negative bacteria// Genes and Immunity. -2003. -Vol. 4. -P. 283-288.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Le Van T.D, Bloom J.W., Bailey T.J. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity// J. Immunol. -2001. -Vol. 167. -P. 5838-5844.</mixed-citation><mixed-citation xml:lang="en">Le Van T.D, Bloom J.W., Bailey T.J. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity// J. Immunol. -2001. -Vol. 167. -P. 5838-5844.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
