mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2006-4-523-530mimmun-481Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРОЛЬ ЭНДОТЕЛИАЛЬНЫХ КЛЕТОК В РЕГУЛЯЦИИ АПОПТОЗА ИНФИЦИРОВАННЫХ ВИЧ-1 СD4+ ЛИМФОЦИТОВROLE OF ENDOTHELIAL CELLS IN REGULATION OF APOPTOSIS OF HIV-1 INFECTED CD4+ LYMPHOCYTESБойчукС. В.BoichukS. V.

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boichuksergei@mail.ruМустафинИ. Г.MustafinI. G.boichuksergei@mail.ruМакароваМ. В.MakarovaM. V.boichuksergei@mail.ruКазанский государственный медицинский университет; Республиканский центр по профилактике и борьбе со СПИД и ИЗ МЗ РТРоссия20062207201484523530Copyright © Бойчук С.В., Мустафин И.Г., Макарова М.В., 20142014Бойчук С.В., Мустафин И.Г., Макарова М.В.Boichuk S.V., Mustafin I.G., Makarova M.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/481

Резюме. Эндотелиальные клетки (ЭК) обладают способностью индуцировать репликацию ВИЧ-1 в СD4 + Т-лимфоцитах (Лф) и обуславливают их резистентность к апоптозу. Выявленные факты являются специфичными и обусловлены особенностями межклеточных взаимодействий между ЭК и клетками-продуцентами ВИЧ-1 и также являются следствием активационного статуса "продуктивно инфицированных" Лф.

Abstract. Vascular endothelial cells (VECs) are able to induce HIV1 replication in СD4+ Tcells, thus determining their resistance for apoptosis. The revealed facts are specific to EC/Tcell culture and are stipulated by the cellcell interactions between the VECs and HIV1 producing cells, thus being a consequence of activation of ‘productively infected’ T cells.

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The authors declare that there are no conflicts of interest present.