References

mimmun

Медицинская иммунология

Medical Immunology (Russia)

1563-06252313-741X

SPb RAACI

10.15789/1563-0625-2005-4-355-364

mimmun-478

Research Article

ОБЗОРЫ

REVIEWS

ИНТЕРЛЕЙКИН–18 И ЕГО РОЛЬ В ИММУННОМ ОТВЕТЕ

IL–18 AND IMMUNITY

Якушенко

Е. В.

Yakushenko

E. V.

г. Новосибирск, ул. Ядринцевская, д. 14

e-yakushenko@mail.ru

Лопатникова

Ю. А.

Lopatnikova

J. A.

e-yakushenko@mail.ru

Сенников

С. В.

Sennikov

S. V.

e-yakushenko@mail.ru

ГУ НИИ Клинической Иммунологии СО РАМН, НовосибирскRussian Federation

2005

22072014

74355364

2014

Якушенко Е.В., Лопатникова Ю.А., Сенников С.В.

Yakushenko E.V., Lopatnikova J.A., Sennikov S.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.mimmun.ru/mimmun/article/view/478

Резюме. Интерлейкин–18 один из основных иммунорегуляторных цитокинов, индуцирующий продукцию IFNγ, что обуславливает его важное значение как фактора противоинфенкционной и противоопухолевой защиты организма. В представленном обзоре рассматриваются молекулярно–генетические и биохимические характеристики IL–18. Приведены данные о клетках продуцентах, строении рецептора и IL–18 связывающего белка, пути передачи сигнала в клетке. Кроме того, рассматриваются основные иммунорегуляторные эффекты IL–18.

Abstract. Interleukin–18 is one of the main cytokines, inducing production of IFNg. It is the important factor of anti–infectious and anti–tumor immunity. The review represent molecular–genetic and biochemical characteristics of IL–18. The data about producers, the structure of the receptor and of IL–18 binding protein, as well as signal transduction in the cell are considered. Besides that, the main immune effects of IL–18 are discussed. (Med. Immunol., 2005, vol.7, № 4, pp 355–364)

цитокиныинтерлейкин-18иммунитет

cytokinesIL-18immunity

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The authors declare that there are no conflicts of interest present.