mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2011-2-3-155-166mimmun-477Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВЫЯВЛЕНИЕ АНТИГЕНСПЕЦИФИЧЕСКИХ ГОРМОНОРЕЗИСТЕНТНЫХ ЛИМФОЦИТОВ КРОВИ ДЛЯ ПРОГНОЗИРОВАНИЯ ЭФФЕКТИВНОСТИ ГЛЮКОКОРТИКОИДНОЙ ТЕРАПИИ БРОНХИАЛЬНОЙ АСТМЫIDENTIFICATION OF ANTIGEN-SPECIFIC HORMONE-RESISTANT BLOOD LYMPHOCYTES TO PREDICT EFFICIENCY OF GLUCOCORTICOID THERAPY IN BRONCHIAL ASTHMAКалашниковаА. А.KalashnikovaA. A.BNV19692007@yandex.ruБычковаН. В.BychkovaN. V.

194044, Санкт-Петербург, ул. Академика Лебедева, 4/2.

BNV19692007@yandex.ruДавыдоваН. И.DavydovaN. I.BNV19692007@yandex.ruЖдановаМ. В.ZhdanovaM. V.BNV19692007@yandex.ruЕвлоеваМ. К.EvloevaM. K.BNV19692007@yandex.ruНовикГ. А.NovikG. A.BNV19692007@yandex.ruФГУЗ ВЦЭРМ им. А.М. Никифорова МЧС России, НИЛ клеточного и гуморального иммунитета, Санкт- ПетербургРоссияГОУ ВПО Санкт-Петербургская государственная педиатрическая медицинская академия Росздрава, Санкт-ПетербургРоссия201122072014132-3155166Copyright © Калашникова А.А., Бычкова Н.В., Давыдова Н.И., Жданова М.В., Евлоева М.К., Новик Г.А., 20142014Калашникова А.А., Бычкова Н.В., Давыдова Н.И., Жданова М.В., Евлоева М.К., Новик Г.А.Kalashnikova A.A., Bychkova N.V., Davydova N.I., Zhdanova M.V., Evloeva M.K., Novik G.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/477 

 

Abstract. At present time, the main therapeutic goal in bronchial asthma treatment is to achieve complete control of the disease. Appropriate medical evaluation involves  a  complex  system  of  clinical  criteria  and functional  parameters  obtained  by  instrumental  and laboratory  techniques.  Wide  application  of  inhalatory glucocorticosteroids (IGCS) in childhood bronchial asthma treatment, requirements for a long-term therapy, and common IGCS dose-escalation regimens determine an importance of searching novel objective criteria to  predict  efficiency  of  the  therapy  preformed.  In  present  work,  we  propose  a  method  aimed  to  identify glucocorticosteroid-resistant lymphocytes in peripheral blood of the patients with bronchial asthma undergoing IGCS therapy. The results of this study have shown that clinical efficiency of such treatment of bronchial asthma patients, independently on the IGCS dosage, may be evaluated by the degree of steroid-induced suppression of in vitro lymphocyte proliferation caused by a domestic dust antigen. The data obtained may be used in clinical settings to predict efficiency of IGCS therapy and adjust treatment regimens in bronchial asthma patients. (Med. Immunol., 2011, vol. 13, N 2-3, pp 157-166)

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The authors declare that there are no conflicts of interest present.