mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2011-1-87-92mimmun-431Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT COMMUNICATIONSОСОБЕННОСТИ ПОЛИМОРФИЗМА HSP70-2 И HSP70-НОМ ГЕНОВ У ПАЦИЕНТОВ С ИНФАРКТОМ МИОКАРДА В АНАМНЕЗЕFEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTIONШевченкоА. В.ShevchenkoA. V.

630117, г. Новосибирск, ул. Академика Тимакова, 2

ГоловановаО. В.GolovanovaO. V.КоненковВ. И.KonenkovV. I.ВоеводаМ. И.VoevodaM. I.МаксимовВ. Н.MaximovV. N.Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. НовосибирскRussian FederationУчреждение Российской академии медицинских наук Научно-исследовательский институт терапии Сибирского отделения РАМН, г. НовосибирскRussian Federation2011210720141318792Copyright © Шевченко А.В., Голованова О.В., Коненков В.И., Воевода М.И., Максимов В.Н., 20142014Шевченко А.В., Голованова О.В., Коненков В.И., Воевода М.И., Максимов В.Н.Shevchenko A.V., Golovanova O.V., Konenkov V.I., Voevoda M.I., Maximov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/431

Резюме. Мы провели анализ ассоциированности аллельного полиморфизма генов белков теплового шока HSP70-2 в позиции 1267А→G и HSP70-НОМ гена в позиции 2437 Т→С у пациентов европеоидного происхождения, перенесших острый инфаркт миокарда (ИМ) с классическими факторами риска его развития.

Частота HSP70-HOM*TC гетерозиготного варианта достоверно выше в группе с индексом массы тела (ИМТ) выше 25 относительно здоровых, а частота HSP70-HOM*CC гомозиготного варианта, напротив, достоверно снижена в группе пациентов с ИМТ выше 25 относительно здоровых. При сравнении частот генотипов между группами пациентов с ИМТ выше 25 и пациентов с нормальным индексом массы тела достоверные различия сохраняются как для частот HSP70-HOM*TC гетерозиготного варианта, так и для HSP70-HOM*CC гомозиготного варианта.

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The authors declare that there are no conflicts of interest present.