mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2012-4-5-305-312mimmun-421Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСУБПОПУЛЯЦИИ МОНОЦИТОВ КРОВИ ПРИ НЕОСЛОЖНЕННОМ ТЕЧЕНИИ ПЕРИОПЕРАЦИОННОГО ПЕРИОДА КОРОНАРНОГО ШУНТИРОВАНИЯBLOOD MONOCYTE SUBPOPULATIONS DURING UNCOMPLICATED CORONARY ARTERY BYPASS SURGERYГоловкинА. С.GolovkinA. S.

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golovkin_a@mail.ruМатвееваВ. Г.MatveevaV. G.golovkin_a@mail.ruКудрявцевИ. В.KudryavtsevI. V.golovkin_a@mail.ruГригорьевЕ. В.GrigorievE. V.golovkin_a@mail.ruВеликановаЕ. А.VelikanovaE. A.golovkin_a@mail.ruБайраковаЮ. В.BairakovaYu. V.golovkin_a@mail.ruНИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. КемеровоРоссияНИИ экспериментальной медицины СЗО РАМН, Санкт-ПетербургРоссия201221072014144-5305312Copyright © Головкин А.С., Матвеева В.Г., Кудрявцев И.В., Григорьев Е.В., Великанова Е.А., Байракова Ю.В., 20142014Головкин А.С., Матвеева В.Г., Кудрявцев И.В., Григорьев Е.В., Великанова Е.А., Байракова Ю.В.Golovkin A.S., Matveeva V.G., Kudryavtsev I.V., Grigoriev E.V., Velikanova E.A., Bairakova Y.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/421

Abstract. We have observed thirty-six patients with coronary artery disease (CAD) who have undergone coronary artery bypass graft (CABG) surgery. In patients with uncomplicated clinical course post-CABG, total lymphocyte counts, T-, B- and NK-cell contents did not significantly differ from baseline levels. Meanwhile, the numbers of CD14HIGH and CD14LOW monocyte subpopulations showed significant differences from initial levels at day 1 and day 7 after surgery. The changes in monocyte subsets in blood of patients with and absence of post-surgical septic complications reflected severity of inflammatory response, and development of systemic inflammatory syndrome. In such a case, further studies of peripheral blood monocytes can be both a useful tool for studying the mechanisms of systemic inflammation, as well as a good diagnostic system, in order to assess the patient’s condition and to predict post-surgical clinical outcomes.

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The authors declare that there are no conflicts of interest present.