mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2010-6-469-476mimmun-417Research ArticleОБЗОРЫREVIEWSСТРУКТУРА И ИММУНОАДЪЮВАНТНЫЕ СВОЙСТВА CPG-ДНКSTRUCTURE AND IMMUNE ADJUVANT PROPERTIES OF CPG-DПоловинкинаВ. С.PolovinkinaV. S.valerisa@list.ruМарковЕ. Ю.MarkovE. Yu.valerisa@list.ruФГУЗ «Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока»
Роспотребнадзора, г. ИркутскRussian Federation201021072014126469476Copyright © Половинкина В.С., Марков Е.Ю., 20142014Половинкина В.С., Марков Е.Ю.Polovinkina V.S., Markov E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/417бактериальная ДНКтолл-подобные рецепторыCpG динуклеотидыадъювантbacterial DNAtoll-like receptorsCpG dinucleotideadjuvant effectsReferencesКозлов И.Г., Тимаков М.А. Иммунотерапия: вчера, сегодня, завтра//Педиатрия. -2009. -Т. 87, № 4. -С. 140-149.Козлов И.Г., Тимаков М.А. Иммунотерапия: вчера, сегодня, завтра//Педиатрия. -2009. -Т. 87, № 4. -С. 140-149.Марков Е.Ю., Николаев В.Б., Загоскина Т.Ю., Половинкина В.С., Иванова Т.А., Саппо С.Г., Андреевская Н.М., Михайлова В.А., Голубинский Е.П. Протективная активность субклеточных фракций Yersinia pestis при экспериментальной чуме у белых мышей//Бюллетень ВСНЦ СО РАМН. -2004. -Т. 2, № 1. -С. 123-127.Марков Е.Ю., Николаев В.Б., Загоскина Т.Ю., Половинкина В.С., Иванова Т.А., Саппо С.Г., Андреевская Н.М., Михайлова В.А., Голубинский Е.П. Протективная активность субклеточных фракций Yersinia pestis при экспериментальной чуме у белых мышей//Бюллетень ВСНЦ СО РАМН. -2004. -Т. 2, № 1. -С. 123-127.Олишевский С.В., Козак В.В., Мазур О.В., Шляховенко В.А. Применение CpG ДНК Bacillus subtilis в экспериментальной иммунотерапии опухолей//Российский биотерапевтический журнал. -2007. -Т. 6, № 3. -С. 19-29.Олишевский С.В., Козак В.В., Мазур О.В., Шляховенко В.А. Применение CpG ДНК Bacillus subtilis в экспериментальной иммунотерапии опухолей//Российский биотерапевтический журнал. -2007. -Т. 6, № 3. -С. 19-29.Половинкина В.С., Иванова Т.А., Николаев В.Б., Марков Е.Ю. Получение микрокорпускулярного антигенного комплекса, способного формировать напряженный иммунитет против чумы на фоне экстренной неспецифической профилактики//Журнал инфекционной патологии. -2009. -Т. 16, № 3. -С. 178-179.Половинкина В.С., Иванова Т.А., Николаев В.Б., Марков Е.Ю. Получение микрокорпускулярного антигенного комплекса, способного формировать напряженный иммунитет против чумы на фоне экстренной неспецифической профилактики//Журнал инфекционной патологии. -2009. -Т. 16, № 3. -С. 178-179.Рыкова Е.Ю., Лактионов П.П., Власов В.В. Активирующее влияние ДНК на иммунную систему//Успехи современной биологии. -2001. -Т. 121, № 2. -С. 160-171.Рыкова Е.Ю., Лактионов П.П., Власов В.В. Активирующее влияние ДНК на иммунную систему//Успехи современной биологии. -2001. -Т. 121, № 2. -С. 160-171.Серебряная Н.Б., Новик А.А. ДНК как иммуностимулятор//Медицинская иммунология. -2001. -Т. 3, № 1. -С. 27-34.Серебряная Н.Б., Новик А.А. ДНК как иммуностимулятор//Медицинская иммунология. -2001. -Т. 3, № 1. -С. 27-34.Akira S., Hoshino K. Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling//J. Infect. Dis. -2003. -Vol. 187, N 2. -P. 356-363.Akira S., Hoshino K. Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling//J. Infect. Dis. -2003. -Vol. 187, N 2. -P. 356-363.Amemiya K., Meyers J.L., Rogers T.E., Fast R.L., Bassett A.D., Worsham P.L., Powell B.S., Norris S.L., Krieg A.M., Adamovicz J.J. CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague//Vaccine. -2009. -Vol. 27, N 16. -P. 2220-2229.Amemiya K., Meyers J.L., Rogers T.E., Fast R.L., Bassett A.D., Worsham P.L., Powell B.S., Norris S.L., Krieg A.M., Adamovicz J.J. CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague//Vaccine. -2009. -Vol. 27, N 16. -P. 2220-2229.Barton G. M., Kagan J. C. A cell biological view of Toll-like receptor function: regulation through compartmentalization//Nature Reviews. Immunology. -2009. -Vol. 9. -P. 535-542.Barton G. M., Kagan J. C. A cell biological view of Toll-like receptor function: regulation through compartmentalization//Nature Reviews. Immunology. -2009. -Vol. 9. -P. 535-542.Beutler B.A. TLRs and innate immunity//Blood. -2009. -Vol. 113. -P. 1399-1407.Beutler B.A. TLRs and innate immunity//Blood. -2009. -Vol. 113. -P. 1399-1407.Branda R.F., Moore A.L., Mathews L., Mc-Cormack J.J., Zon G. Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1//Biochem. Pharmacol. -1993. -Vol. 45, N 10. -P. 2037-2043.Branda R.F., Moore A.L., Mathews L., Mc-Cormack J.J., Zon G. Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1//Biochem. Pharmacol. -1993. -Vol. 45, N 10. -P. 2037-2043.Chuang T., Ulevitch R.J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9//Eur. Cytokine Netw. -2000. -Vol. 11. -P. 372-378.Chuang T., Ulevitch R.J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9//Eur. Cytokine Netw. -2000. -Vol. 11. -P. 372-378.Cooper C.L., Davis H.L., Angel J.B., Morris M.L., Elfer S.M., Seguin I., Krieg A.M., Cameron D.W. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults//AIDS. -2005. -Vol. 19, N 14. -P. 1473-1479.Cooper C.L., Davis H.L., Angel J.B., Morris M.L., Elfer S.M., Seguin I., Krieg A.M., Cameron D.W. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults//AIDS. -2005. -Vol. 19, N 14. -P. 1473-1479.De Francesco R., Migliaccio G. Challenges and successes in developing new therapies for hepatitis C//Nature. -2005. -Vol. 436, N 18. -P. 953-960.De Francesco R., Migliaccio G. Challenges and successes in developing new therapies for hepatitis C//Nature. -2005. -Vol. 436, N 18. -P. 953-960.Elkins K.L., Rhinehart-Jones T.R., Stibitz S., Conover J.S., Klinman D.M. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria//J. Immunol. -1999. -Vol. 162, N 4. -P. 2291-2298.Elkins K.L., Rhinehart-Jones T.R., Stibitz S., Conover J.S., Klinman D.M. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria//J. Immunol. -1999. -Vol. 162, N 4. -P. 2291-2298.Heit A., Schmitz F., O'Keeffe M., Staib C., Busch D.H., Wagner H., Huster K.M. Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines//J. Immunol. -2005. -Vol. 174, N 7. -P. 4373-4380.Heit A., Schmitz F., O'Keeffe M., Staib C., Busch D.H., Wagner H., Huster K.M. Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines//J. Immunol. -2005. -Vol. 174, N 7. -P. 4373-4380.Jin M.S., Lee J.O. Structures of the Toll-like receptor family and its ligand complexes//Immunity. -2008. -Vol. 29. -P. 182-191.Jin M.S., Lee J.O. Structures of the Toll-like receptor family and its ligand complexes//Immunity. -2008. -Vol. 29. -P. 182-191.Jurk M., Vollmer J. Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation//BioDrugs. -2007. -Vol. 21, N 6. -P. 387-401.Jurk M., Vollmer J. Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation//BioDrugs. -2007. -Vol. 21, N 6. -P. 387-401.Kaushik P., Singh D.K., Kumar S.V., Tiwari A.K., Shukla G., Dayal S., Chaudhuri P. Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides//Vet. Res. Commun. -2010. -Vol. 34, N 2. -P. 119-132.Kaushik P., Singh D.K., Kumar S.V., Tiwari A.K., Shukla G., Dayal S., Chaudhuri P. Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotides//Vet. Res. Commun. -2010. -Vol. 34, N 2. -P. 119-132.Kawai T., Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition//Int. Immunol. -2009. -Vol. 21, N 4. -P. 317-337.Kawai T., Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition//Int. Immunol. -2009. -Vol. 21, N 4. -P. 317-337.Kumar H., Kawai T., Akira S. Toll-like receptors and innate immunity//Biochemical and Biophysical Research Communications. -2009. -Vol. 388. -P. 621-625.Kumar H., Kawai T., Akira S. Toll-like receptors and innate immunity//Biochemical and Biophysical Research Communications. -2009. -Vol. 388. -P. 621-625.Markov E.Yu., Nikolaev V.B., Ivanova T.A., Golubinsky E.P., Innokenteva T.I., Dubrovina V.I., Polovinkina V.S., Popova Yu.O., Vitjazeva O.I., Kozlov S.N. Protective activity of Yersinia pestis EV antigenic complex with the immunostimulators and combined use of doxycyclin//Scientific Journal of Center for Infectious Diseases with Natural Foci. -2005. -P. 176-184.Markov E.Yu., Nikolaev V.B., Ivanova T.A., Golubinsky E.P., Innokenteva T.I., Dubrovina V.I., Polovinkina V.S., Popova Yu.O., Vitjazeva O.I., Kozlov S.N. Protective activity of Yersinia pestis EV antigenic complex with the immunostimulators and combined use of doxycyclin//Scientific Journal of Center for Infectious Diseases with Natural Foci. -2005. -P. 176-184.Matsumoto S., Matsumoto M., Umemori K., Ozeki Y., Furugen M., Tatsuo T., Hirayama Y., Yamamoto S., Yamada T., Kobayashi K. DNA augments antigenicity of mycobacterial DNA-binding protein 1 and confers protection against Mycobacterium tuberculosis infection in mice//J. Immunol. -2005. -Vol. 175, N 1. -P. 441-449.Matsumoto S., Matsumoto M., Umemori K., Ozeki Y., Furugen M., Tatsuo T., Hirayama Y., Yamamoto S., Yamada T., Kobayashi K. DNA augments antigenicity of mycobacterial DNA-binding protein 1 and confers protection against Mycobacterium tuberculosis infection in mice//J. Immunol. -2005. -Vol. 175, N 1. -P. 441-449.Medvedev A.E., Lentschat A., Kuhns D.B. Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections//J. Exp. Med. -2003. -Vol. 798. -P. 521-531.Medvedev A.E., Lentschat A., Kuhns D.B. Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections//J. Exp. Med. -2003. -Vol. 798. -P. 521-531.Medzhitov R. Recognition of microorganisms and activation of the immune response//Nature. -2007. -Vol. 449. -P. 819-826.Medzhitov R. Recognition of microorganisms and activation of the immune response//Nature. -2007. -Vol. 449. -P. 819-826.Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity//Nature. -1997. -Vol. 333. -P. 394-397.Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity//Nature. -1997. -Vol. 333. -P. 394-397.O'Neill L.A., Bryant C.E., Doyle S.L. Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer//Pharmacol. Rev. -2009. -Vol. 61, N 2. -P. 177-197.O'Neill L.A., Bryant C.E., Doyle S.L. Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer//Pharmacol. Rev. -2009. -Vol. 61, N 2. -P. 177-197.Pisetsky D.S., Reich C.F. The influence of base sequence on the immunological properties of defined oligonucleotides//Immunopharmacology. -1998. -Vol. 40, N 3. -P. 199-208.Pisetsky D.S., Reich C.F. The influence of base sequence on the immunological properties of defined oligonucleotides//Immunopharmacology. -1998. -Vol. 40, N 3. -P. 199-208.Ringwood L., Li L. The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation//Cytokine. -2008. -Vol. 42, N 1. -P. 1-7.Ringwood L., Li L. The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation//Cytokine. -2008. -Vol. 42, N 1. -P. 1-7.Samulowitz U., Weber M., Weeratna R., Uhlmann E., Noll B., Krieg A.M., Vollmer J.A. Novel Class of Immune-Stimulatory CpG Oligodeoxynucleotides Unifies High Potency in Type I Interferon Induction with Preferred Structural Properties//Oligonucleotides. -2010. -Vol. 20, N 2. -P. 93-101.Samulowitz U., Weber M., Weeratna R., Uhlmann E., Noll B., Krieg A.M., Vollmer J.A. Novel Class of Immune-Stimulatory CpG Oligodeoxynucleotides Unifies High Potency in Type I Interferon Induction with Preferred Structural Properties//Oligonucleotides. -2010. -Vol. 20, N 2. -P. 93-101.Taghavi A., Allan B., Mutwiri G., Foldvari M., Van Kessel A., Willson P., Babiuk L., Potter A., Gomis S. Enhancement of immunoprotective effect of CpG-ODN by formulation with polyphosphazenes against E. coli septicemia in neonatal chickens//Curr. Drug Deliv. -2009. -Vol. 6, N 1. -P. 76-82.Taghavi A., Allan B., Mutwiri G., Foldvari M., Van Kessel A., Willson P., Babiuk L., Potter A., Gomis S. Enhancement of immunoprotective effect of CpG-ODN by formulation with polyphosphazenes against E. coli septicemia in neonatal chickens//Curr. Drug Deliv. -2009. -Vol. 6, N 1. -P. 76-82.Tokunaga T., Yamamoto S., Namba K. A synthetic single-stranded DNA, poly (dG,dC), induces interferon-α/βand -γ, augments natural killer activity, and suppresses tumor growth//Jpn. J. Cancer Res. -1988. -Vol. 79, N 6. -P. 682-686.Tokunaga T., Yamamoto S., Namba K. A synthetic single-stranded DNA, poly (dG,dC), induces interferon-α/βand -γ, augments natural killer activity, and suppresses tumor growth//Jpn. J. Cancer Res. -1988. -Vol. 79, N 6. -P. 682-686.Uddowla S., Freytag L.C., Clements J.D. Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens//Vaccine. -2007. -Vol. 25, N 47. -P. 7984-7993.Uddowla S., Freytag L.C., Clements J.D. Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens//Vaccine. -2007. -Vol. 25, N 47. -P. 7984-7993.van Maren W.W., Jacobs J.F., de Vries I.J., Nierkens S., Adema G.J. Toll-like receptor signalling on Tregs: to suppress or not to suppress?//Immunology. -2008. -Vol. 124, N 4. -P. 445-452.van Maren W.W., Jacobs J.F., de Vries I.J., Nierkens S., Adema G.J. Toll-like receptor signalling on Tregs: to suppress or not to suppress?//Immunology. -2008. -Vol. 124, N 4. -P. 445-452.Vollmer J., Krieg A.M. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists//Advanced Drug Delivery Reviews. -2009. -Vol. 61. -P. 195-204.Vollmer J., Krieg A.M. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists//Advanced Drug Delivery Reviews. -2009. -Vol. 61. -P. 195-204.Yamamoto S., Yamamoto T., Shimada S., Kuramoto E., Yano O, Kataoka T., Tokunaga T. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth//Microbiol. Immunol. -1992. -Vol. 36, N 9. -P. 983-997.Yamamoto S., Yamamoto T., Shimada S., Kuramoto E., Yano O, Kataoka T., Tokunaga T. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth//Microbiol. Immunol. -1992. -Vol. 36, N 9. -P. 983-997.Yu P. Nucleic acid recognizing Toll-like receptors as therapeutic targets: a focus on autoimmunity and cancer//Journal of Receptor, Ligand and Channel Research. -2009. -Vol. 2. -P. 19-28.Yu P. Nucleic acid recognizing Toll-like receptors as therapeutic targets: a focus on autoimmunity and cancer//Journal of Receptor, Ligand and Channel Research. -2009. -Vol. 2. -P. 19-28.
The authors declare that there are no conflicts of interest present.