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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2012-4-5-279-288</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-416</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>АЛЛЕРГИЯ К КЛЕЩАМ ДОМАШНЕЙ ПЫЛИ С ПОЗИЦИЙ МОЛЕКУЛЯРНОЙ АЛЛЕРГОЛОГИИ</article-title><trans-title-group xml:lang="en"><trans-title>HOUSE DUST MITE ALLERGY IN VIEW OF MOLECULAR ALLERGOLOGY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коровкина</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Korovkina</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>105064, Москва, Малый Казенный пер., 5а. Тел.: (495) 917-08-91. Факс: (495) 917-49-00.</p></bio><email xlink:type="simple">elen208@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мокроносова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mokronosova</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">elen208@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ вакцин и сывороток им. И.И. Мечникова РАМН, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>21</day><month>07</month><year>2014</year></pub-date><volume>14</volume><issue>4-5</issue><fpage>279</fpage><lpage>288</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коровкина Е.С., Мокроносова М.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Коровкина Е.С., Мокроносова М.А.</copyright-holder><copyright-holder xml:lang="en">Korovkina E.S., Mokronosova M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/416">https://www.mimmun.ru/mimmun/article/view/416</self-uri><abstract/><trans-abstract xml:lang="en"><p>Abstract. Incidence of allergic diseases is increased over last years. House dust is considered a major risk factor of allergic sensitization which plays an important role in development of allergic rhinitis, bronchial asthma, atopic dermatitis. Dust mites in the home comprise a large part of domestic allergens. Dermatophagoides pteronyssinus, Dermatophagoides farinae, Euroglyphus maynei, Lepidoglyphus destructor, Blomia tropicalis are most important in this respect. Der p 1 and Der p 2 are regarded as major house dust mite allergens. Recent studies concerned induction of IgE responses against mite tropomyosin (Der p 10), an allergen occurring in mites which exhibits high cross-reactivity with tropomyosins from a variety of sea foods (e.g. shrimps), as well as human tropomyosins. Allergen-specific immunotherapy (ASIT) represents the only causative approach to allergy treatment in such cases. From this viewpoint, a quantitation of specific IgЕ against major house dust mite allergens would be necessary to predict ASIT efficiency. Treatment by house dust mites allergen extracts is effective in management of allergic rhinitis and mild asthma. A component-resolved diagnostic (CRD) with purified house-dust mites allergens allows to discriminate patients who were mostly sensitized to the major house dust mites allergens (e.g. Der p 10, tropomyosin). The component-resolved diagnostics could be performed before starting the allergen-specific immunotherapy by mite allergens, in order to avoid unresponsiveness to this mode of therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>клещи домашней пыли</kwd><kwd>Der p 1</kwd><kwd>Der p 2</kwd><kwd>тропомиозин</kwd><kwd>компонентная иммунологическая диагностика</kwd><kwd>аллерген-специфическая иммунотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>house dust mites</kwd><kwd>Der p 1</kwd><kwd>Der p 2</kwd><kwd>tropomyosin</kwd><kwd>component-resolved immune diagnostics</kwd><kwd>allergen-specific immunotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева О.В., Гущин И.С. Контролируемые исследования эффективности и безопасности аллергенспецифической иммунотерапии: исторический аспект // Российский аллергологический журнал. – 2011. – № 4. – С. 3-14.</mixed-citation><mixed-citation xml:lang="en">Воробьева О.В., Гущин И.С. Контролируемые исследования эффективности и безопасности аллергенспецифической иммунотерапии: исторический аспект // Российский аллергологический журнал. – 2011. – № 4. – С. 3-14.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Желтикова Т.М., Антропова А.Б., Петрова-Никитина А.Д., Мокеева В.Л., Биланенко Е.Н., Чекунова Л.Н. Экология жилых помещений и аллергия // Аллергология. – 2004. – № 3. – C. 20-28.</mixed-citation><mixed-citation xml:lang="en">Желтикова Т.М., Антропова А.Б., Петрова-Никитина А.Д., Мокеева В.Л., Биланенко Е.Н., Чекунова Л.Н. Экология жилых помещений и аллергия // Аллергология. – 2004. – № 3. – C. 20-28.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Желтикова Т.М., Мокроносова М.А. Распространение клещей амбарно-зернового комплекса и их роль в сенсибилизации жителей г. Москвы // Бюллетень экспериментальной медицины и биологии. – 1991. – № 4. – С. 396-398.</mixed-citation><mixed-citation xml:lang="en">Желтикова Т.М., Мокроносова М.А. Распространение клещей амбарно-зернового комплекса и их роль в сенсибилизации жителей г. Москвы // Бюллетень экспериментальной медицины и биологии. – 1991. – № 4. – С. 396-398.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Коровкина Е.С., Курбачева О.М., Ильина Н.И. Стандартные подходы к диагностике и лечению аллергического ринита // Российский аллергологический журнал. – 2005. – № 3. – С. 21-26.</mixed-citation><mixed-citation xml:lang="en">Коровкина Е.С., Курбачева О.М., Ильина Н.И. Стандартные подходы к диагностике и лечению аллергического ринита // Российский аллергологический журнал. – 2005. – № 3. – С. 21-26.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Курбачева О.М., Ильина Н.И., Лусс Л.В. Современная диагностика и терапия аллергического ринита: рациональность и обоснованность выбора // Аллергология. – 2003. – № 3. – C. 51-54.</mixed-citation><mixed-citation xml:lang="en">Курбачева О.М., Ильина Н.И., Лусс Л.В. Современная диагностика и терапия аллергического ринита: рациональность и обоснованность выбора // Аллергология. – 2003. – № 3. – C. 51-54.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Мокроносова М.А. Сенсибилизация к клещам амбарно-зернового комплекса // Терапевтический архив. – 1991. – № 3. – С. 53-55. 7. Сергеев А.В., Мокроносова М.А. Синдром оральной аллергии // Медицинская иммунология. – 2011. – Т. 13, № 1. – C. 17-28.</mixed-citation><mixed-citation xml:lang="en">Мокроносова М.А. Сенсибилизация к клещам амбарно-зернового комплекса // Терапевтический архив. – 1991. – № 3. – С. 53-55. 7. Сергеев А.В., Мокроносова М.А. Синдром оральной аллергии // Медицинская иммунология. – 2011. – Т. 13, № 1. – C. 17-28.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Читаева В.Г., Гущин И.С. Диагностическая значимость кожных проб и определения аллерген-cпецифического IgE при респираторной и пищевой аллергии // Российский аллергологический журнал. – 2008. – № 3. – C. 3-14.</mixed-citation><mixed-citation xml:lang="en">Читаева В.Г., Гущин И.С. Диагностическая значимость кожных проб и определения аллерген-cпецифического IgE при респираторной и пищевой аллергии // Российский аллергологический журнал. – 2008. – № 3. – C. 3-14.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Akdemir C., Soyucen E. Sensitization of children to storage mites in Kutahya, Turkey // Korean. J. Parasitol. – 2009. – Vol. 47 (4). – P. 387-391.</mixed-citation><mixed-citation xml:lang="en">Akdemir C., Soyucen E. Sensitization of children to storage mites in Kutahya, Turkey // Korean. J. Parasitol. – 2009. – Vol. 47 (4). – P. 387-391.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Allergic Rhinitis and its Impact on Asthma (ARIA) in collaboration with the World Health Organization (WHO) // J. Allergy Clin. Immunol. – 2001. – Vol. 108. – Suppl. – P. 147-336.</mixed-citation><mixed-citation xml:lang="en">Allergic Rhinitis and its Impact on Asthma (ARIA) in collaboration with the World Health Organization (WHO) // J. Allergy Clin. Immunol. – 2001. – Vol. 108. – Suppl. – P. 147-336.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Allergen immunotherapy therapeutic vaccines for allergic diseases. WHO Position Paper // Allergy. – 1998. – Vol. 53. – P. 1-42 .</mixed-citation><mixed-citation xml:lang="en">Allergen immunotherapy therapeutic vaccines for allergic diseases. WHO Position Paper // Allergy. – 1998. – Vol. 53. – P. 1-42 .</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez-Cuesta E., Bousquet J., Canonica G.W., Durham S.R., Malling H.J., Valovirta E.; EAACI, Immunotherapy Task Force. Standarts for practical allergen-specific immunotherapy // Allergy. – 2006. – Vol. 61. – P. 1-23.</mixed-citation><mixed-citation xml:lang="en">Alvarez-Cuesta E., Bousquet J., Canonica G.W., Durham S.R., Malling H.J., Valovirta E.; EAACI, Immunotherapy Task Force. Standarts for practical allergen-specific immunotherapy // Allergy. – 2006. – Vol. 61. – P. 1-23.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Arlian L.G., Neal J.S., Morgan M.S., Vyszenski-Moher D.L., Rapp C.M., Alexander A.K. Reducing relative humidity is a practical way to control dust mites and their allergens in homes in temperate climates // J. Allergy Clin. Immunol. – 2001. – Vol. 107, N 1. – P. 99-104.</mixed-citation><mixed-citation xml:lang="en">Arlian L.G., Neal J.S., Morgan M.S., Vyszenski-Moher D.L., Rapp C.M., Alexander A.K. Reducing relative humidity is a practical way to control dust mites and their allergens in homes in temperate climates // J. Allergy Clin. Immunol. – 2001. – Vol. 107, N 1. – P. 99-104.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Arlian L.G., Platts-Mills T.A. The biology of dust mites and the remediation of mite allergens in allergic disease // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (3 Suppl). – P. 406-413.</mixed-citation><mixed-citation xml:lang="en">Arlian L.G., Platts-Mills T.A. The biology of dust mites and the remediation of mite allergens in allergic disease // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (3 Suppl). – P. 406-413.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Asturias J.A., Arilla M.C., Gomez-Bayon N.N., Mart nez A., Mart nez J., Palacios R. Sequencing and high level expression in Escherichia coli of the tropomyosin allergen (Der p 10) from Dermatophagoides pteronyssinus // Biochim. Biophys.Acta. – 1998. –Vol. 1397. – P. 27-30.</mixed-citation><mixed-citation xml:lang="en">Asturias J.A., Arilla M.C., Gomez-Bayon N.N., Mart nez A., Mart nez J., Palacios R. Sequencing and high level expression in Escherichia coli of the tropomyosin allergen (Der p 10) from Dermatophagoides pteronyssinus // Biochim. Biophys.Acta. – 1998. –Vol. 1397. – P. 27-30.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Asyuso R., Reese G., Leong-Kee S., Plante M., Lehrer S.B. Molecular basis of arthropod cross-reactivity: IgE-binding cross-reactive epitopes of srimp, hous-dust mite and cockroach tropomyosins // Int. Arch. Allergy Immunol. – 2002. – Vol. 129. – P. 38-48.</mixed-citation><mixed-citation xml:lang="en">Asyuso R., Reese G., Leong-Kee S., Plante M., Lehrer S.B. Molecular basis of arthropod cross-reactivity: IgE-binding cross-reactive epitopes of srimp, hous-dust mite and cockroach tropomyosins // Int. Arch. Allergy Immunol. – 2002. – Vol. 129. – P. 38-48.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bush R.K., Portnoy J.M. The role and abatement of fungal allergens in allergic diseases // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (3 Suppl). – P. 430-440 18. Chapman M.D. Environmental allergen monitoring and control // Allergy. – 1998. – Vol. 53. – P. 48-53.</mixed-citation><mixed-citation xml:lang="en">Bush R.K., Portnoy J.M. The role and abatement of fungal allergens in allergic diseases // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (3 Suppl). – P. 430-440 18. Chapman M.D. Environmental allergen monitoring and control // Allergy. – 1998. – Vol. 53. – P. 48-53.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Choi S.Y., Lee I.Y., Sohn J.H., Lee Y.W., Shin Y.S., Yong T.S., Hong C.S., Park J.W. Optimal conditions for the removal of house dust mite, dog dander, and pollen allergens using mechanical laundry // Ann. Allergy Asthma Immunol. – 2008. – Vol. 100, N 6. – Р. 583-588.</mixed-citation><mixed-citation xml:lang="en">Choi S.Y., Lee I.Y., Sohn J.H., Lee Y.W., Shin Y.S., Yong T.S., Hong C.S., Park J.W. Optimal conditions for the removal of house dust mite, dog dander, and pollen allergens using mechanical laundry // Ann. Allergy Asthma Immunol. – 2008. – Vol. 100, N 6. – Р. 583-588.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cuesta C., Pl cido J.L., Delgado L., Miranda M., Moreira Silva J.P., Castel-Branco M.G., Vaz M. Cockroach allergy: a study of its prevalence using skin tests with commercial extracts // Allergol. Immunopathol. (Madr). – 1995. – Nov-Dec. – Vol. 23 (6). – P. 295-300.</mixed-citation><mixed-citation xml:lang="en">Cuesta C., Pl cido J.L., Delgado L., Miranda M., Moreira Silva J.P., Castel-Branco M.G., Vaz M. Cockroach allergy: a study of its prevalence using skin tests with commercial extracts // Allergol. Immunopathol. (Madr). – 1995. – Nov-Dec. – Vol. 23 (6). – P. 295-300.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Custovic A., Chapman M. Risk levels for mite allergens. Are they meaningful? // Allergy. – 1998. – Vol. 53 (Suppl. 48). – P. 71-76.</mixed-citation><mixed-citation xml:lang="en">Custovic A., Chapman M. Risk levels for mite allergens. Are they meaningful? // Allergy. – 1998. – Vol. 53 (Suppl. 48). – P. 71-76.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandez-Caldas E. Mite species of allergologie importance in Europe // Allergy. – 1997. – Vol. 52. – P. 383-387.</mixed-citation><mixed-citation xml:lang="en">Fernandez-Caldas E. Mite species of allergologie importance in Europe // Allergy. – 1997. – Vol. 52. – P. 383-387.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gafvelin G., Johansson E., Lundin A., Smith A.M., Chapman M.D., Benjamin D.C., Derewenda U., van Hage-Hamsten M. Cross-reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus, Gly d 2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae with recombinant allergens // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (3). – P. 511-518</mixed-citation><mixed-citation xml:lang="en">Gafvelin G., Johansson E., Lundin A., Smith A.M., Chapman M.D., Benjamin D.C., Derewenda U., van Hage-Hamsten M. Cross-reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus, Gly d 2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae with recombinant allergens // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (3). – P. 511-518</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">G mez C., S nchez-Garc a S., Ib ez M.D., L pez R., Aguado E., L pez E., Sastre B., Sastre J., Del Pozo V. Tropomyosin IgE-positive results are a good predictor of shrimp allergy // Allergy. – 2011 – Vol. 66 (10). – P. 1375-1383</mixed-citation><mixed-citation xml:lang="en">G mez C., S nchez-Garc a S., Ib ez M.D., L pez R., Aguado E., L pez E., Sastre B., Sastre J., Del Pozo V. Tropomyosin IgE-positive results are a good predictor of shrimp allergy // Allergy. – 2011 – Vol. 66 (10). – P. 1375-1383</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">GINA Report, Global Strategy for Asthma Management and Prevention. Published November 2006 // http://www.ginasthma.org.</mixed-citation><mixed-citation xml:lang="en">GINA Report, Global Strategy for Asthma Management and Prevention. Published November 2006 // http://www.ginasthma.org.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Gr nlund H., Saarne T., Gafvelin G., van Hage M. The major cat allergen, Fel d 1, in diagnosis and therapy // Int. Arch. Allergy Immunol. – 2010. – Vol. 151 (4). – P. 265-274.</mixed-citation><mixed-citation xml:lang="en">Gr nlund H., Saarne T., Gafvelin G., van Hage M. The major cat allergen, Fel d 1, in diagnosis and therapy // Int. Arch. Allergy Immunol. – 2010. – Vol. 151 (4). – P. 265-274.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hage-Hamsten M. van, Johansson E. Clinical and immunologic aspects of storage mite allergy // Allergy. – 1998. – Vol. 53 (Suppl. 48). – P. 49-53.</mixed-citation><mixed-citation xml:lang="en">Hage-Hamsten M. van, Johansson E. Clinical and immunologic aspects of storage mite allergy // Allergy. – 1998. – Vol. 53 (Suppl. 48). – P. 49-53.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hales B.J., Shen H.D, Thomas W.R. Crossreactivity of T-cell responses to Dermatophagoides pteronyssinus and D. farinae. Studies with group 1 and 7 allergens // Clin. Exp. Allergy. – 2000. – Vol. 30 (7). – P. 927-933.</mixed-citation><mixed-citation xml:lang="en">Hales B.J., Shen H.D, Thomas W.R. Crossreactivity of T-cell responses to Dermatophagoides pteronyssinus and D. farinae. Studies with group 1 and 7 allergens // Clin. Exp. Allergy. – 2000. – Vol. 30 (7). – P. 927-933.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Johansson E., Aponno M., Lundberg M., Van Hage-Hamsten M. Allergenic cross-reactivity between the nematode Anisakis simplex and the dust mites Acarussiro, Lepidoglyphus destructor, Tyrophagus putrescentiae, and Dermatophagoides pteronyssinus // Allergy. – Vol. 56. – Issue 7. – P. 660-666.</mixed-citation><mixed-citation xml:lang="en">Johansson E., Aponno M., Lundberg M., Van Hage-Hamsten M. Allergenic cross-reactivity between the nematode Anisakis simplex and the dust mites Acarussiro, Lepidoglyphus destructor, Tyrophagus putrescentiae, and Dermatophagoides pteronyssinus // Allergy. – Vol. 56. – Issue 7. – P. 660-666.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kerkhof M., Droste J.H.J., de Monchf J.G.R., Schouten J.P., Rijcken B. Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20-70 years // Allergy. – 1996. – Vol. 51. – P. 770-776.</mixed-citation><mixed-citation xml:lang="en">Kerkhof M., Droste J.H.J., de Monchf J.G.R., Schouten J.P., Rijcken B. Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20-70 years // Allergy. – 1996. – Vol. 51. – P. 770-776.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kim Y.K., Lee M.H., Jee Y.K., Hong S.C., Bae J.M., Chang Y.S., Jung J.W., Lee B.J., Son J.W., Cho S.H., Min K.U., Kim Y.Y. Spider mite allergy in apple-cultivating farmers: European red mite (Panonychusulmi) and two-spotted spider mite (Tetranychusurticae) may be important allergens in the development of work-related asthma and rhinitis symptoms // J. Allergy Clin. Immunol. – 1999. – Vol. 104 (6). – P. 1285-1292.</mixed-citation><mixed-citation xml:lang="en">Kim Y.K., Lee M.H., Jee Y.K., Hong S.C., Bae J.M., Chang Y.S., Jung J.W., Lee B.J., Son J.W., Cho S.H., Min K.U., Kim Y.Y. Spider mite allergy in apple-cultivating farmers: European red mite (Panonychusulmi) and two-spotted spider mite (Tetranychusurticae) may be important allergens in the development of work-related asthma and rhinitis symptoms // J. Allergy Clin. Immunol. – 1999. – Vol. 104 (6). – P. 1285-1292.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">King C., Brennan S., Thompson P.J., Stewart G.A. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium // J. Immunol. – 1998. – Vol. 161. – P. 3645-3651.</mixed-citation><mixed-citation xml:lang="en">King C., Brennan S., Thompson P.J., Stewart G.A. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium // J. Immunol. – 1998. – Vol. 161. – P. 3645-3651.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">King T.P., Hoffman D., Lowenstein H., Marsh D.G., Platts-Mills T.A., Thomas W. Allergen nomenclature // Allergy. – 1995. – Vol. 50. – P. 765-774.</mixed-citation><mixed-citation xml:lang="en">King T.P., Hoffman D., Lowenstein H., Marsh D.G., Platts-Mills T.A., Thomas W. Allergen nomenclature // Allergy. – 1995. – Vol. 50. – P. 765-774.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lopata A.L., Lehrer S. New insights into seafood allergy // Curr. Opin. Allergy Clin. Immunol. – 2009. – Vol. 9. – P. 270-277.</mixed-citation><mixed-citation xml:lang="en">Lopata A.L., Lehrer S. New insights into seafood allergy // Curr. Opin. Allergy Clin. Immunol. – 2009. – Vol. 9. – P. 270-277.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mellerup M.T., Hahn G.W., Poulsen L.K., Malling H. Safety of allergen-specific immunotherapy. Relation between dosage regiment, allergen extract, disease and systemic side-effect during induction treatment // Clin. Exp. Allergy. – 2000. – Vol. 30. – P. 1423-1429.</mixed-citation><mixed-citation xml:lang="en">Mellerup M.T., Hahn G.W., Poulsen L.K., Malling H. Safety of allergen-specific immunotherapy. Relation between dosage regiment, allergen extract, disease and systemic side-effect during induction treatment // Clin. Exp. Allergy. – 2000. – Vol. 30. – P. 1423-1429.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller G. A., Edwards L.L., Aloor J.J., Fessler M.B., Glesner J., Pomes A., Chapman M.D., London R.E., Pedersen L.C. The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins // J. Allergy Clin. Immunol. – 2010. – Vol. 125 (4). – P. 909-917.</mixed-citation><mixed-citation xml:lang="en">Mueller G. A., Edwards L.L., Aloor J.J., Fessler M.B., Glesner J., Pomes A., Chapman M.D., London R.E., Pedersen L.C. The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins // J. Allergy Clin. Immunol. – 2010. – Vol. 125 (4). – P. 909-917.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Partti-Pellinen K., Marttila O., MaèkinenKiljunen S., Haahtela T. Occurrence of dog, cat, and mite allergens in public transport vehicles // Allergy. – 2000. – Vol. 55. – P. 65-68.</mixed-citation><mixed-citation xml:lang="en">Partti-Pellinen K., Marttila O., MaèkinenKiljunen S., Haahtela T. Occurrence of dog, cat, and mite allergens in public transport vehicles // Allergy. – 2000. – Vol. 55. – P. 65-68.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Pauli G. Evolution of understanding of cross-reactivities of respiratory allergens: the role of recombinant allergens // Int. Arch. Allergy Immunol. – 2000. – Vol. 123. – P. 183-195.</mixed-citation><mixed-citation xml:lang="en">Pauli G. Evolution of understanding of cross-reactivities of respiratory allergens: the role of recombinant allergens // Int. Arch. Allergy Immunol. – 2000. – Vol. 123. – P. 183-195.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Peake H.L., Currie A.J., Stewart G.A, McWilliam A.S. Nitric oxide production by alveolar macrophages in response to house dust mite fecal pellets and the mite allergens, Der p 1 and Der p 2 //</mixed-citation><mixed-citation xml:lang="en">Peake H.L., Currie A.J., Stewart G.A, McWilliam A.S. Nitric oxide production by alveolar macrophages in response to house dust mite fecal pellets and the mite allergens, Der p 1 and Der p 2 //</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">J. Allergy Clin. Immunol. – 2003. – Vol. 112 (3). – P. 531-537.</mixed-citation><mixed-citation xml:lang="en">J. Allergy Clin. Immunol. – 2003. – Vol. 112 (3). – P. 531-537.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Pittner G., Vrtala S., Thomas W.R., Weghofer M., Kundi M., Horak F., Kraft D., Valenta R. Component-resolved diagnosis of house-dust mite allergy with purified natural and recombinant mite allergens // Clin. Exp. Allergy. – 2004. – Vol. 34 (4). – P. 597-603.</mixed-citation><mixed-citation xml:lang="en">Pittner G., Vrtala S., Thomas W.R., Weghofer M., Kundi M., Horak F., Kraft D., Valenta R. Component-resolved diagnosis of house-dust mite allergy with purified natural and recombinant mite allergens // Clin. Exp. Allergy. – 2004. – Vol. 34 (4). – P. 597-603.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Platts-Mills T.A., Vervloet D., Thomas W.R., Aalberse R.C., Chapman M.D. Indoor allergens and asthma: report of the Third International Workshop // J. Allergy Clin. Immunol. – 1997. – Vol. 100 (6). – P. 2-24.</mixed-citation><mixed-citation xml:lang="en">Platts-Mills T.A., Vervloet D., Thomas W.R., Aalberse R.C., Chapman M.D. Indoor allergens and asthma: report of the Third International Workshop // J. Allergy Clin. Immunol. – 1997. – Vol. 100 (6). – P. 2-24.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Pongracic J.A., O’Connor G.T., Muilenberg M.L., Vaughn B., Gold D.R., Kattan M., Morgan W.J., Gruchalla R.S., Smartt E., Mitchell H.E. Differential effects of outdoor versus indoor fungal spores on asthma morbidity in innercity children // J. Allergy Clin. Immunol. – 2010. – Vol. 125 (3). – P. 593-599.</mixed-citation><mixed-citation xml:lang="en">Pongracic J.A., O’Connor G.T., Muilenberg M.L., Vaughn B., Gold D.R., Kattan M., Morgan W.J., Gruchalla R.S., Smartt E., Mitchell H.E. Differential effects of outdoor versus indoor fungal spores on asthma morbidity in innercity children // J. Allergy Clin. Immunol. – 2010. – Vol. 125 (3). – P. 593-599.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ree R. van. Analytic aspects of the standardization of allergenic extracts // Allergy. – 1997. – Vol. 52. – P. 795-805.</mixed-citation><mixed-citation xml:lang="en">Ree R. van. Analytic aspects of the standardization of allergenic extracts // Allergy. – 1997. – Vol. 52. – P. 795-805.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Santos A.B., Rocha G.M., Oliver C., Ferriani V.P., Lima R.C., Palma M.S., Sales V.S, Aalberse R.C, Chapman M.D., Arruda L.K. Crossreactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach // J. Allergy Clin. Immunol. – 2008 – Vol. 121 (4). – P. 1040-1046.</mixed-citation><mixed-citation xml:lang="en">Santos A.B., Rocha G.M., Oliver C., Ferriani V.P., Lima R.C., Palma M.S., Sales V.S, Aalberse R.C, Chapman M.D., Arruda L.K. Crossreactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach // J. Allergy Clin. Immunol. – 2008 – Vol. 121 (4). – P. 1040-1046.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Scala E., Alessandri C., Palazzo P., Pomponi D., Liso M., Bernardi M.L, Ferrara R., Zennaro D., Santoro M., Rasi C., Mari A. IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by fllergen microarray-based technology // PLoS One. – 2011. – Vol. 6 (9). – e24912.</mixed-citation><mixed-citation xml:lang="en">Scala E., Alessandri C., Palazzo P., Pomponi D., Liso M., Bernardi M.L, Ferrara R., Zennaro D., Santoro M., Rasi C., Mari A. IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by fllergen microarray-based technology // PLoS One. – 2011. – Vol. 6 (9). – e24912.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sever M.L., Arbes S.J., Gore J., Santangelo R.G., Vaughn B., Mitchell H., Schal C., Zeldin D.C. Cockroach allergen reduction by cockroach control alone in low-income urban homes: A randomized control trial // J. Allergy Clin. Immunol. – 2007. – Vol. 120. –P. 849-855.</mixed-citation><mixed-citation xml:lang="en">Sever M.L., Arbes S.J., Gore J., Santangelo R.G., Vaughn B., Mitchell H., Schal C., Zeldin D.C. Cockroach allergen reduction by cockroach control alone in low-income urban homes: A randomized control trial // J. Allergy Clin. Immunol. – 2007. – Vol. 120. –P. 849-855.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Sidenius K.E., Hallas T.E., Poulsen L.K., Mosbech H. Allergen cross-reactivity between house-dust mites and other invertebrates // Allergy. – 2001. – Vol. 56 (8). – P. 723-33.</mixed-citation><mixed-citation xml:lang="en">Sidenius K.E., Hallas T.E., Poulsen L.K., Mosbech H. Allergen cross-reactivity between house-dust mites and other invertebrates // Allergy. – 2001. – Vol. 56 (8). – P. 723-33.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Smith A.M., Benjamin D.C., Hozic N., Derewenda U., Smith W.A, Thomas W.R, Gafvelin G., van Hage-Hamsten M., Chapman M.D. The molecular basis of antigenic cross-reactivity between the group 2 mite allergens // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (6). – P. 977-84.</mixed-citation><mixed-citation xml:lang="en">Smith A.M., Benjamin D.C., Hozic N., Derewenda U., Smith W.A, Thomas W.R, Gafvelin G., van Hage-Hamsten M., Chapman M.D. The molecular basis of antigenic cross-reactivity between the group 2 mite allergens // J. Allergy Clin. Immunol. – 2001. – Vol. 107 (6). – P. 977-84.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Son J.W., Kim H.Y., Park H.S., Lee M.H., Cho S.H., Min K.U., Kim Y.Y. Citrus red mite (Panonychuscitri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers // Clin. Exp. Allergy. – 1999. – Vol. 29 (8). – P. 1102-1109.</mixed-citation><mixed-citation xml:lang="en">Son J.W., Kim H.Y., Park H.S., Lee M.H., Cho S.H., Min K.U., Kim Y.Y. Citrus red mite (Panonychuscitri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers // Clin. Exp. Allergy. – 1999. – Vol. 29 (8). – P. 1102-1109.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Strachan D., Sibbald B., Weiland S., A t-Khaled N., Anabwani G., Anderson H.R., Asher M.I., Beasley R., Bj rkst n B., Burr M., Clayton T., Crane J., Ellwood P., Keil U., Lai C., Mallol J., Martinez F., Mitchell E., Montefort S., Pearce N., Robertson C., Shah J., Stewart A., von Mutius E., Williams H. Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the international study of asthma and allergies in childhood (ISAAC) // Pediatr. Allergy Immunol. – 1997. – Vol. 8. – P. 161-176.</mixed-citation><mixed-citation xml:lang="en">Strachan D., Sibbald B., Weiland S., A t-Khaled N., Anabwani G., Anderson H.R., Asher M.I., Beasley R., Bj rkst n B., Burr M., Clayton T., Crane J., Ellwood P., Keil U., Lai C., Mallol J., Martinez F., Mitchell E., Montefort S., Pearce N., Robertson C., Shah J., Stewart A., von Mutius E., Williams H. Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the international study of asthma and allergies in childhood (ISAAC) // Pediatr. Allergy Immunol. – 1997. – Vol. 8. – P. 161-176.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas W.R., Smith W. House-dust mite allergens // Allergy. – 1998. – Vol. 53. – P. 821-832.</mixed-citation><mixed-citation xml:lang="en">Thomas W.R., Smith W. House-dust mite allergens // Allergy. – 1998. – Vol. 53. – P. 821-832.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas W.R, Smith W.A., Hales B.J. The allergenic specificities of the house dust mite // Chang. Gung. Med. J. – 2004. – Vol. 27 (8). – P. 563-569.</mixed-citation><mixed-citation xml:lang="en">Thomas W.R, Smith W.A., Hales B.J. The allergenic specificities of the house dust mite // Chang. Gung. Med. J. – 2004. – Vol. 27 (8). – P. 563-569.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas W.R., Smith W.A., Hales B.J., Mills K.L., O’Brien R.M. Characterization and immunobiology of house dust mite allergens // Int. Arch.Allergy Immunol. – 2002. – Vol. 129 (1). – P. 1-18.</mixed-citation><mixed-citation xml:lang="en">Thomas W.R., Smith W.A., Hales B.J., Mills K.L., O’Brien R.M. Characterization and immunobiology of house dust mite allergens // Int. Arch.Allergy Immunol. – 2002. – Vol. 129 (1). – P. 1-18.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Valenta R., Linholm J., Niederberger V., Hayek B., Kraft D., Gronlund H. The recombinant allergen-based concept of component-resolved diagnosis and immunotherapy (CD and CRIT) // Clin. Exp. Allergy. – 1999. – Vol. 29. – P. 896-904.</mixed-citation><mixed-citation xml:lang="en">Valenta R., Linholm J., Niederberger V., Hayek B., Kraft D., Gronlund H. The recombinant allergen-based concept of component-resolved diagnosis and immunotherapy (CD and CRIT) // Clin. Exp. Allergy. – 1999. – Vol. 29. – P. 896-904.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Vrtala S. From allergen genes to new forms of allergy diagnosis and treatment // Allergy. – 2008. – Vol. 63. – P. 299-309.</mixed-citation><mixed-citation xml:lang="en">Vrtala S. From allergen genes to new forms of allergy diagnosis and treatment // Allergy. – 2008. – Vol. 63. – P. 299-309.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Warner A., Bostrom S., Moller C., Kjellman N.-I.M. Mite fauna in the home and sensitivity to house dust and storage mites // Allergy. – 1999. – Vol. 54. – P. 681-690.</mixed-citation><mixed-citation xml:lang="en">Warner A., Bostrom S., Moller C., Kjellman N.-I.M. Mite fauna in the home and sensitivity to house dust and storage mites // Allergy. – 1999. – Vol. 54. – P. 681-690.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Zock J.P., Heinrich J., Jarvis D., Verlato G., Norb ck D., Plana E., Sunyer J., Chinn S., Olivieri M., Soon A., Villani S., Ponzio M., Dahlman-Hoglund A., Svanes C., Luczynska C. Indoor Working Group of the European Community Respiratory Health Survey Il. Distribution and determinants of house dust mite allergens in Europe: The European Community Respiratory Health Survey II // J. Allergy Clin. Immunol. – 2006. – Vol. 118, N 3. – P. 682-690.</mixed-citation><mixed-citation xml:lang="en">Zock J.P., Heinrich J., Jarvis D., Verlato G., Norb ck D., Plana E., Sunyer J., Chinn S., Olivieri M., Soon A., Villani S., Ponzio M., Dahlman-Hoglund A., Svanes C., Luczynska C. Indoor Working Group of the European Community Respiratory Health Survey Il. Distribution and determinants of house dust mite allergens in Europe: The European Community Respiratory Health Survey II // J. Allergy Clin. Immunol. – 2006. – Vol. 118, N 3. – P. 682-690.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
