mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2006-1-23-30mimmun-414Research ArticleОБЗОРЫREVIEWSДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ КЛИНИЧЕСКОЙ АБЗИМОЛОГИИADVANCES AND PERSPECTIVES OF CLINICAL ABZYMOLOGYСучковС. В.SuchkovS. V.khitrov@wolga.msk.ruАлекбероваЗ. С.AlekberovaZ. S.khitrov@wolga.msk.ruХитровА. Н.HitrovA. N.

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khitrov@wolga.msk.ruШогеновЗ. С.ShogenovZ. S.khitrov@wolga.msk.ruВоскресенскаяО. В.VoskresenskayaO. V.khitrov@wolga.msk.ruГнучевН. В.GnuchevN. V.khitrov@wolga.msk.ruГабибовА. Г.GabibovA. G.khitrov@wolga.msk.ruМОНИКИ им. М.Ф. Владимирского, МоскваРоссияГУ Институт ревматологии РАМН, МоскваРоссияММА им. И.М. Сеченова, МоскваРоссияГКБ №81, МоскваРоссияИнститут биоорганической химии им. М.М. Шемякина и Ю.А. Овчинникова РАН, МоскваРоссияМГУ им. М.В. Ломоносова, МоскваРоссияИнститут биологии гена РАН, МоскваРоссия200621072014812330Copyright © Сучков С.В., Алекберова З.С., Хитров А.Н., Шогенов З.С., Воскресенская О.В., Гнучев Н.В., Габибов А.Г., 20142014Сучков С.В., Алекберова З.С., Хитров А.Н., Шогенов З.С., Воскресенская О.В., Гнучев Н.В., Габибов А.Г.Suchkov S.V., Alekberova Z.S., Hitrov A.N., Shogenov Z.S., Voskresenskaya O.V., Gnuchev N.V., Gabibov A.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/414

Резюме. Природные каталитические аутоантитела (абзимы), обладающие протеолитической (протабзимы) и ДНК-гидролизующей активностью (ДНК-абзимы) выявляются при аутоиммунной патологии в клинике и в эксперименте. Описана каталитическая активность абзимов у больных с различными формами системной (органонеспецифической) и органоспецифической аутоиммунной патологии, а также возможность их использования для мониторинга активности аутоиммунных заболеваний.

Abstract. Natural catalytic autoantibodies (abzymes) posessing proteolytic (protoabzymes) and DNA-hydrolysing (DNA-abzymes) activities are detectable in clinical and experimental autoimmune disorders. Catalytic activity of abzymes is revealed in the patients with different forms of systemic (nonspecific) and organ-specific autoimmune pathology. The opportunity of assaying the abzymes for intensity monitoring of autoimmune disease is also described.

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The authors declare that there are no conflicts of interest present.