<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2010-1-2-20-40</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-38</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>НАТУРАЛЬНЫЕ КИЛЛЕРЫ Т-КЛЕТКИ ЛЕЙКОЦИТАРНЫХ ИНФИЛЬТРАТОВ ПЕЧЕНИ БОЛЬНЫХ С ОПУХОЛЕВЫМ ПРОЦЕССОМ И ВИРУСНЫМ ГЕПАТИТОМ</article-title><trans-title-group xml:lang="en"><trans-title>NATURAL KILLER T CELLS IN HEPATIC LEUCOCYTE INFILTRATES IN PATIENTS WITH MALIGNANT PROCESS AND VIRAL HEPATITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебединская</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedinskaya</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">lebedinska@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кабановская</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kabanovskaja</surname><given-names>I. N.</given-names></name></name-alternatives><email xlink:type="simple">lebedinska@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахматова</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmatova</surname><given-names>N. K.</given-names></name></name-alternatives><email xlink:type="simple">lebedinska@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебединская</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedinskaya</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">lebedinska@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">lebedinska@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киселевский</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiselevsky</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">lebedinska@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО «Пермская государственная медицинская академия им. академика Е.А. Вагнера МЗ РФ», г. Пермь</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ГУ «Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН», Москва</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>ГОУ ВПО «Московская государственная медицинская академия им. И.М. Сеченова», Москва</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>ГУ «Российский онкологический научный центр им. Н.Н. Блохина», Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>08</day><month>07</month><year>2014</year></pub-date><volume>12</volume><issue>1-2</issue><fpage>20</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лебединская О.В., Кабановская И.Н., Ахматова Н.К., Лебединская Е.А., Лазарева А.В., Киселевский М.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Лебединская О.В., Кабановская И.Н., Ахматова Н.К., Лебединская Е.А., Лазарева А.В., Киселевский М.В.</copyright-holder><copyright-holder xml:lang="en">Lebedinskaya O.V., Kabanovskaja I.N., Akhmatova N.K., Lebedinskaya E.A., Lazareva A.V., Kiselevsky M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/38">https://www.mimmun.ru/mimmun/article/view/38</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>натуральные киллеры</kwd><kwd>натуральные киллеры Т-клетки</kwd><kwd>печень</kwd><kwd>лейкоцитарные инфильтраты</kwd><kwd>опухолевый процесс</kwd><kwd>вирусный гепатит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>natural killers</kwd><kwd>natural T-killer cells</kwd><kwd>liver</kwd><kwd>leicocyte infiltrates</kwd><kwd>tumor process</kwd><kwd>viral hepatitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chang Y.J., Huang J.R., Tsai Y.C., Hung J.T., Wu D., Fujio M., Wong C.H., Yu A.L. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids // Proc. Natl. Acad. Sci. USA. – 2007. – Vol. 104, N 25. – P. 10299-10304.</mixed-citation><mixed-citation xml:lang="en">Chang Y.J., Huang J.R., Tsai Y.C., Hung J.T., Wu D., Fujio M., Wong C.H., Yu A.L. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids // Proc. Natl. Acad. Sci. USA. – 2007. – Vol. 104, N 25. – P. 10299-10304.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Crowe N.Y., Uldrich A.P., Kyparissoudis K., Hammond K.J., Hayakawa Y., Sidobre S., Keating R., Kronenberg M., Smyth M.J., Godfrey D.I. Glycolipid antigen drives rapid expansion and sustained cytokine production by NKT cells // J. Immunol. – 2003. – Vol. 171. – P. 4020-4027.</mixed-citation><mixed-citation xml:lang="en">Crowe N.Y., Uldrich A.P., Kyparissoudis K., Hammond K.J., Hayakawa Y., Sidobre S., Keating R., Kronenberg M., Smyth M.J., Godfrey D.I. Glycolipid antigen drives rapid expansion and sustained cytokine production by NKT cells // J. Immunol. – 2003. – Vol. 171. – P. 4020-4027.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dhodapkar M.V., Geller M.D., Chang D.H., Shimizu K., Fujii S., Dhodapkar K.M., Krasovsky J. A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma // J. Exp. Med. – 2003. – Vol. 197. – P.1667-1676.</mixed-citation><mixed-citation xml:lang="en">Dhodapkar M.V., Geller M.D., Chang D.H., Shimizu K., Fujii S., Dhodapkar K.M., Krasovsky J. A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma // J. Exp. Med. – 2003. – Vol. 197. – P.1667-1676.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Exley M.A., Koziel M.J. To Be or Not to Be NKT: Natural Killer T Cells in the Liver // Hepatology. – 2004. – Vol. 40, N 5. – P. 1033-1040.</mixed-citation><mixed-citation xml:lang="en">Exley M.A., Koziel M.J. To Be or Not to Be NKT: Natural Killer T Cells in the Liver // Hepatology. – 2004. – Vol. 40, N 5. – P. 1033-1040.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Exley M.A., He Q., Cheng O., Wang R.J., Cheney C.P., Balk S.P., Koziel M.J. Cutting edge: compartmentalization of Th1-like noninvariant CD1dreactive T cells in hepatitis C virus-infected liver // J. Immunol. – 2002. – Vol. 168. – P. 1519-1523.</mixed-citation><mixed-citation xml:lang="en">Exley M.A., He Q., Cheng O., Wang R.J., Cheney C.P., Balk S.P., Koziel M.J. Cutting edge: compartmentalization of Th1-like noninvariant CD1dreactive T cells in hepatitis C virus-infected liver // J. Immunol. – 2002. – Vol. 168. – P. 1519-1523.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fuji N., Ueda Y., Fujiwara H., Toh T., Yoshimura T., Yamagishi H. Antitumor effect of a-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver // Clinical Cancer Research. – 2000. – Vol. 6, N 8. – P. 3380-3387.</mixed-citation><mixed-citation xml:lang="en">Fuji N., Ueda Y., Fujiwara H., Toh T., Yoshimura T., Yamagishi H. Antitumor effect of a-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver // Clinical Cancer Research. – 2000. – Vol. 6, N 8. – P. 3380-3387.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fuji S., Shimizu K., Smith C. Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein // J. Exp. Med. – 2003. – Vol. 198. – P. 267-279.</mixed-citation><mixed-citation xml:lang="en">Fuji S., Shimizu K., Smith C. Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein // J. Exp. Med. – 2003. – Vol. 198. – P. 267-279.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Godfrey D.I., MacDonald H.R., Kronenberg M.M., Smyth M.J., Van Kaer L. NKT cells: what’s in a name? // Nat. Rev. Immunol. – 2004. – Vol. 4. – P. 231-237.</mixed-citation><mixed-citation xml:lang="en">Godfrey D.I., MacDonald H.R., Kronenberg M.M., Smyth M.J., Van Kaer L. NKT cells: what’s in a name? // Nat. Rev. Immunol. – 2004. – Vol. 4. – P. 231-237.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hammond K.J.L., Pelikan S.B., Crowe N.Y., Randle-Barrett E., Nakayama T., Taniguchi M., Smyth M.J., van Driel I.R., Scollay R., Baxter A.G., Godfrey D.I. NKT cells are phenotypically and functionally diverse // Eur. J. Immunol. – 1999. – Vol. 29. – P. 3768-3781.</mixed-citation><mixed-citation xml:lang="en">Hammond K.J.L., Pelikan S.B., Crowe N.Y., Randle-Barrett E., Nakayama T., Taniguchi M., Smyth M.J., van Driel I.R., Scollay R., Baxter A.G., Godfrey D.I. NKT cells are phenotypically and functionally diverse // Eur. J. Immunol. – 1999. – Vol. 29. – P. 3768-3781.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kakimi K., Guidotti L.G., Koezuka Y., Chisari F.V. Natural killer T cell activation inhibits hepatitis B virus replication in vivo // J. Exp. Med. – 2000. – Vol. 192, N 7. – P. 921-930.</mixed-citation><mixed-citation xml:lang="en">Kakimi K., Guidotti L.G., Koezuka Y., Chisari F.V. Natural killer T cell activation inhibits hepatitis B virus replication in vivo // J. Exp. Med. – 2000. – Vol. 192, N 7. – P. 921-930.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kenna T., Mason L.G., Porcelli S.A., Koezuka Y., Hegarty J.E., O’Farrelly C., Doherty D.G. NKT cells from normal and tumor-bearing human liver are phenotypically and functionally distinct from murine NKT cells // J. Immunol. – 2003. – Vol. 166, N 11. – P. 6578-6584.</mixed-citation><mixed-citation xml:lang="en">Kenna T., Mason L.G., Porcelli S.A., Koezuka Y., Hegarty J.E., O’Farrelly C., Doherty D.G. NKT cells from normal and tumor-bearing human liver are phenotypically and functionally distinct from murine NKT cells // J. Immunol. – 2003. – Vol. 166, N 11. – P. 6578-6584.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kenna T., Mason L.G., Porcelli S.A., Koezuka Y., Hegarty J.E., O’Farrelly C., Doherty D.G. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells // J. Immunol. – 2003. – Vol. 171. – P. 1775-1779.</mixed-citation><mixed-citation xml:lang="en">Kenna T., Mason L.G., Porcelli S.A., Koezuka Y., Hegarty J.E., O’Farrelly C., Doherty D.G. NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells // J. Immunol. – 2003. – Vol. 171. – P. 1775-1779.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kenna T., Golden-Mason L., Porcelli S.A., Koezuka Y., Hegarty J.E., O’Farrelly C., Doherty D.G. CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver // Cancer Immunol Immunother. – 2007. – Vol. 56, N 4. – P. 563-72.</mixed-citation><mixed-citation xml:lang="en">Kenna T., Golden-Mason L., Porcelli S.A., Koezuka Y., Hegarty J.E., O’Farrelly C., Doherty D.G. CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver // Cancer Immunol Immunother. – 2007. – Vol. 56, N 4. – P. 563-72.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kikuchi A., Nieda M., Koezuka Y., Ishihara S., IshikawaY., Tadokoro K., Durrant S., Boyd S., Juji T., Nicol A. In vitro anti-tumour activity of alphagalactosylceramide-stimulated human invariant Valpha24 + NKT cells against melanoma // Br. J. Cancer. – 2001. – Vol. 85. – P. 741-746.</mixed-citation><mixed-citation xml:lang="en">Kikuchi A., Nieda M., Koezuka Y., Ishihara S., IshikawaY., Tadokoro K., Durrant S., Boyd S., Juji T., Nicol A. In vitro anti-tumour activity of alphagalactosylceramide-stimulated human invariant Valpha24 + NKT cells against melanoma // Br. J. Cancer. – 2001. – Vol. 85. – P. 741-746.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kitamura H., Iwakabe K., Yahata T., Nishimura S., Ohta A., Ohmi Y., Sato M., Takeda K., Okumura K., Van Kaer L., Kawano T., Taniguchi M., Nishimura T. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells // J. Exp. Med. –1999. – Vol. 189. – P. 1121-1127.</mixed-citation><mixed-citation xml:lang="en">Kitamura H., Iwakabe K., Yahata T., Nishimura S., Ohta A., Ohmi Y., Sato M., Takeda K., Okumura K., Van Kaer L., Kawano T., Taniguchi M., Nishimura T. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells // J. Exp. Med. –1999. – Vol. 189. – P. 1121-1127.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes // Annual review of immunology. – 2005. – Vol. 23. – P. 877-900.</mixed-citation><mixed-citation xml:lang="en">Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes // Annual review of immunology. – 2005. – Vol. 23. – P. 877-900.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Levy O., Orange J.S., Hibberd P., Steinberg S., LaRussa P., Weinberg A., Wilson S.B., Shaulov A., Fleisher G., Geha R.S., Bonilla F.A., Exley M. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a ovel deficiency in natural killer T cells // J. Infect. Dis. – 2003. – Vol. 188. – P. 948-953.</mixed-citation><mixed-citation xml:lang="en">Levy O., Orange J.S., Hibberd P., Steinberg S., LaRussa P., Weinberg A., Wilson S.B., Shaulov A., Fleisher G., Geha R.S., Bonilla F.A., Exley M. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a ovel deficiency in natural killer T cells // J. Infect. Dis. – 2003. – Vol. 188. – P. 948-953.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuda J.L., Gapin L., Baron J.L., Sidobre S., Stetson D.B., Mohrs M., Locksley R.M., Kronenberg M. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo // Proc. Natl. Acad. Sci. U. S. A. – 2003. – Vol. 100. – P. 8395-8400.</mixed-citation><mixed-citation xml:lang="en">Matsuda J.L., Gapin L., Baron J.L., Sidobre S., Stetson D.B., Mohrs M., Locksley R.M., Kronenberg M. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo // Proc. Natl. Acad. Sci. U. S. A. – 2003. – Vol. 100. – P. 8395-8400.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Metelitsa L.S., Naidenko O.V., Kant A., Wu H.W., Loza M.J., Perussia B., Kronenberg M., Seeger R.C. Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells // J. Immunol. – 2001. – Vol. 167. – P. 3114-3122.</mixed-citation><mixed-citation xml:lang="en">Metelitsa L.S., Naidenko O.V., Kant A., Wu H.W., Loza M.J., Perussia B., Kronenberg M., Seeger R.C. Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells // J. Immunol. – 2001. – Vol. 167. – P. 3114-3122.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Motohashi S., Kobayashi S., Ito T., Magara K.K., Mikuni O., Kamada N., Iizasa T., Nakayama T., Fujisawa T., Taniguchi M. Preserved IFN-alpha production of circulating V alpha 24 NKT cells in primary lung cancer patients // Int. J. Cancer. – 2002. – Vol. 102. – P. 159-165.</mixed-citation><mixed-citation xml:lang="en">Motohashi S., Kobayashi S., Ito T., Magara K.K., Mikuni O., Kamada N., Iizasa T., Nakayama T., Fujisawa T., Taniguchi M. Preserved IFN-alpha production of circulating V alpha 24 NKT cells in primary lung cancer patients // Int. J. Cancer. – 2002. – Vol. 102. – P. 159-165.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pillai A.B., George T.I., Dutt S., Teo P., Strober S. NKT cells can prevent graft-versushost disease and permit graft antitumor activity after bone marrow transplantation. // J. Immunol. – 2007. – Vol. 178, N 10. – P. 6242-51.</mixed-citation><mixed-citation xml:lang="en">Pillai A.B., George T.I., Dutt S., Teo P., Strober S. NKT cells can prevent graft-versushost disease and permit graft antitumor activity after bone marrow transplantation. // J. Immunol. – 2007. – Vol. 178, N 10. – P. 6242-51.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Poulton L.D., Smyth M.J., Hawke C.G., Silveira P., Shepherd D., Naidenko O.V., Godfrey D.I., Baxter A.G. Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice // Int. Immunol. – 2001. – Vol. 13. – P. 887-896.</mixed-citation><mixed-citation xml:lang="en">Poulton L.D., Smyth M.J., Hawke C.G., Silveira P., Shepherd D., Naidenko O.V., Godfrey D.I., Baxter A.G. Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice // Int. Immunol. – 2001. – Vol. 13. – P. 887-896.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Seino K., Motohashi S., Fujisawa T., Nakayama T., Taniguchi M. Natural killer T cellmediated antitumor i mmune responses and their clinical applications // Cancer Sci. – 2006. – Vol. 97, N 9. – P. 807-812.</mixed-citation><mixed-citation xml:lang="en">Seino K., Motohashi S., Fujisawa T., Nakayama T., Taniguchi M. Natural killer T cellmediated antitumor i mmune responses and their clinical applications // Cancer Sci. – 2006. – Vol. 97, N 9. – P. 807-812.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Smyth M.J., Godfrey D.I. NKT cells and tumor immunity-a double-edged sword // Nat. Immunol. – 2000. – Vol. 1. – P. 459-460.</mixed-citation><mixed-citation xml:lang="en">Smyth M.J., Godfrey D.I. NKT cells and tumor immunity-a double-edged sword // Nat. Immunol. – 2000. – Vol. 1. – P. 459-460.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Smyth M.J., Crowe N.Y., Takeda K. NKT cells – conductors of tumor immunity? // Curr. Opin. Immunol. – 2002. – Vol. 14. – P. 165-171.</mixed-citation><mixed-citation xml:lang="en">Smyth M.J., Crowe N.Y., Takeda K. NKT cells – conductors of tumor immunity? // Curr. Opin. Immunol. – 2002. – Vol. 14. – P. 165-171.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sonoda K.H., Taniguchi M., Stein-Streilein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells // J. Immunol. – 2002. – Vol. 168. – P. 2028-2034.</mixed-citation><mixed-citation xml:lang="en">Sonoda K.H., Taniguchi M., Stein-Streilein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells // J. Immunol. – 2002. – Vol. 168. – P. 2028-2034.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Spadaro M., Curcio C., Varadhachary A., Cavallo F., Engelmayer J., Blezinger P., Pericle F., Forni G. Requirement for IFN-gamma, CD8+ T lymphocytes, and NKT cells in talactoferrininduced inhibition of neu + tumors // Cancer Res. – 2007. – Vol. 67, N 13. – P. 6425-32.</mixed-citation><mixed-citation xml:lang="en">Spadaro M., Curcio C., Varadhachary A., Cavallo F., Engelmayer J., Blezinger P., Pericle F., Forni G. Requirement for IFN-gamma, CD8+ T lymphocytes, and NKT cells in talactoferrininduced inhibition of neu + tumors // Cancer Res. – 2007. – Vol. 67, N 13. – P. 6425-32.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Swann J.B., Coquet J.M., Smyth M.J., Godfrey D.I. CD1-restricted T cells and tumor immunity // Curr. Top. Microbiol. Immunol. –2007. – Vol. 314. – P. 293-323.</mixed-citation><mixed-citation xml:lang="en">Swann J.B., Coquet J.M., Smyth M.J., Godfrey D.I. CD1-restricted T cells and tumor immunity // Curr. Top. Microbiol. Immunol. –2007. – Vol. 314. – P. 293-323.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Trobonjaca Z., Leith user F., M ller P., Schirmbeck R., Reimann J. Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFNγ release by liver NKT cells // J. Immunol. – 2001. – Vol. 167, N 3. – P. 1413-1422.</mixed-citation><mixed-citation xml:lang="en">Trobonjaca Z., Leith user F., M ller P., Schirmbeck R., Reimann J. Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFNγ release by liver NKT cells // J. Immunol. – 2001. – Vol. 167, N 3. – P. 1413-1422.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Trobonjaca Z., Kroger A., Stober D., Leith user F., M ller P., Hauser H., Schirmbeck R., Reimann J. Activating immunity in the liver. II. IFNb attenuates NK cell-dependent liver injury triggered by liver NKT cell activation // J. Immunol. – 2002. – Vol. 168, N 8. – P. 3763-3770.</mixed-citation><mixed-citation xml:lang="en">Trobonjaca Z., Kroger A., Stober D., Leith user F., M ller P., Hauser H., Schirmbeck R., Reimann J. Activating immunity in the liver. II. IFNb attenuates NK cell-dependent liver injury triggered by liver NKT cell activation // J. Immunol. – 2002. – Vol. 168, N 8. – P. 3763-3770.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson S.B., Delovitch T.L. Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity // Nat. Rev. Immunol. – 2003. – Vol. 3. – P. 211-222.</mixed-citation><mixed-citation xml:lang="en">Wilson S.B., Delovitch T.L. Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity // Nat. Rev. Immunol. – 2003. – Vol. 3. – P. 211-222.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
