<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2012-3-213-218</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-350</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ СУБМАКСИМАЛЬНОЙ ФИЗИЧЕСКОЙ НАГРУЗКИ НА КЛЕТОЧНЫЕ ПАРАМЕТРЫ КРОВИ СПОРТСМЕНОВ</article-title><trans-title-group xml:lang="en"><trans-title>INFLUENCE OF SUB-MAXIMAL PHYSICAL LOAD ON BLOOD CELL PARAMETERS IN ATHLETES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвинова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinova</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лаборатория иммунологии и клеточных биотехнологий Инновационного парка БФУ им. И. Канта236000, г. Калининград, ул. А. Невского, 14 (с пометкой: для Инновационного парка) Тел.: (4012) 59-55-95, 59-66-31</p></bio><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пельменев</surname><given-names>В. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Pelmenev</surname><given-names>V. К.</given-names></name></name-alternatives><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селедцова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Seledtsova</surname><given-names>I. А.</given-names></name></name-alternatives><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муравьева</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Muravyeva</surname><given-names>Yu. А.</given-names></name></name-alternatives><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шуплецова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Schupletsova</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Panin</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончаров</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharov</surname><given-names>A. G.</given-names></name></name-alternatives><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селедцов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Seledtsov</surname><given-names>V. I.</given-names></name></name-alternatives><email xlink:type="simple">larisalitvinova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Балтийский федеральный университет им. И. Канта, г. Калининград<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>20</day><month>07</month><year>2014</year></pub-date><volume>14</volume><issue>3</issue><fpage>213</fpage><lpage>218</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Литвинова Л.С., Пельменев В.К., Селедцова И.А., Муравьева Ю.А., Шуплецова В.В., Панин В.А., Гончаров А.Г., Селедцов В.И., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Литвинова Л.С., Пельменев В.К., Селедцова И.А., Муравьева Ю.А., Шуплецова В.В., Панин В.А., Гончаров А.Г., Селедцов В.И.</copyright-holder><copyright-holder xml:lang="en">Litvinova L.S., Pelmenev V.К., Seledtsova I.А., Muravyeva Y.А., Schupletsova V.V., Panin V.A., Goncharov A.G., Seledtsov V.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/350">https://www.mimmun.ru/mimmun/article/view/350</self-uri><abstract><p>Резюме. Реакции клеток крови на субмаксимальную физическую нагрузку были исследованы у спортсменов (9 мужчин от 18 до 22 лет), занимающихся единоборствами. Субпопуляционный анализ клеток проводили через 7, 35 и 60 мин после окончания физической нагрузки. Через 7 мин был выявлен абсолютный прирост в крови общего количества клеток, эритроцитов, нейтрофилов, моноцитов и T-лимфоцитов. В это время был выявлен не только абсолютный, но и относительный прирост естественных киллерных клеток (СD16+ и СD56+), В-клеток (CD19+), а также стволовых клеток (СD34+ СD133+). Важно то, что к 35 минуте после окончания нагрузки клеточные параметры возвращались к исходным значениям. Мы предполагаем, что изменения клеточного состава крови в первые минуты после завершения физической нагрузки могут характеризовать физический потенциал спортсмена, а их оценка может быть использована для оптимизации его тренировочного процесса.</p></abstract><trans-abstract xml:lang="en"><p>Abstract. Blood cell reactions to a submaximal physical load were studied in nine male athletes aged from 18 to 22 years, involved in wrestling sports. Subpopulational profiling of blood cell was performed 7, 35, and 60 min after completing the physical exercises. An absolute increase in total nucleated cells, erythrocytes, neutrophils, monocytes, and T-lymphocytes was noted in blood counts at the 7-min time-point. Both absolute and relative increases were revealed for СD16+ and СD56+ natural killer cells, CD19+ B-cells, as well as for stem-like cell population (CD34+CD133+) at this period. It is worth of mention that all the tested blood parameters returned to basal ranges within 35 min after the physical exercise was completed. We suggest that the changes in blood cell parameters observed during first minutes after the physical load may characterize a physical potential of athletes. Thus, evaluation of these indices may be used for optimizing their training efforts.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>физическая нагрузка</kwd><kwd>клеточные параметры крови</kwd></kwd-group><kwd-group xml:lang="en"><kwd>physical load</kwd><kwd>blood cell parameters</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Федеральная целевая программа «Научные и научно-педагогические кадры инновационной России» на 2009-2013 годы (ГК № П329; № П405</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лакин Г.Ф. Биометрия. – М.: Высшая школа, 1980. – 296 с.</mixed-citation><mixed-citation xml:lang="en">Лакин Г.Ф. Биометрия. – М.: Высшая школа, 1980. – 296 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Чередеев А.Н. CD-маркеры в практике клинико-диагностических лабораторий // Клин. лаб. диагностика. – 1999. – № 6. – С. 25-32.</mixed-citation><mixed-citation xml:lang="en">Чередеев А.Н. CD-маркеры в практике клинико-диагностических лабораторий // Клин. лаб. диагностика. – 1999. – № 6. – С. 25-32.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Clarke A.W., Alyas F., Morris T., Robertson C.J., Bell J., Connell D.A. Skin-derived tenocyte-like cells for the treatment of patellar tendinopathy // Am. J. Sports Med. – 2011. – Vol. 39, N 3. – Р. 614-23.</mixed-citation><mixed-citation xml:lang="en">Clarke A.W., Alyas F., Morris T., Robertson C.J., Bell J., Connell D.A. Skin-derived tenocyte-like cells for the treatment of patellar tendinopathy // Am. J. Sports Med. – 2011. – Vol. 39, N 3. – Р. 614-23.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Graca L., Cobbold S.P., Waldmann H. Identification of regulatory T cells in tolerated allografts // J. Exp. Med. – 2002. – Vol. 195, N 12. – P. 1641-1646.</mixed-citation><mixed-citation xml:lang="en">Graca L., Cobbold S.P., Waldmann H. Identification of regulatory T cells in tolerated allografts // J. Exp. Med. – 2002. – Vol. 195, N 12. – P. 1641-1646.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gulotta L.V., Kovacevic D., Montgomery S., Ehteshami J.R., Packer J.D., Rodeo S.A. Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site // Am. J. Sports Med. – 2010. – Vol. 38, N 7. – Р. 1429-1437.</mixed-citation><mixed-citation xml:lang="en">Gulotta L.V., Kovacevic D., Montgomery S., Ehteshami J.R., Packer J.D., Rodeo S.A. Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site // Am. J. Sports Med. – 2010. – Vol. 38, N 7. – Р. 1429-1437.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hoetzer G.L., Van Guilder G.P., Irmiger H.M., Keith R.S., Stauffer B.L., DeSouza C.A.J. Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men // Appl. Physiol. – 2007. – Vol. 102, N 3. – P. 847-52.</mixed-citation><mixed-citation xml:lang="en">Hoetzer G.L., Van Guilder G.P., Irmiger H.M., Keith R.S., Stauffer B.L., DeSouza C.A.J. Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men // Appl. Physiol. – 2007. – Vol. 102, N 3. – P. 847-52.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Karim M., Bushell A.R., Wood K.J. Regulatory T-cells in transplantation // Current Opinion in immunology. – 2002. – Vol. 14, N 5. – P. 584-591.</mixed-citation><mixed-citation xml:lang="en">Karim M., Bushell A.R., Wood K.J. Regulatory T-cells in transplantation // Current Opinion in immunology. – 2002. – Vol. 14, N 5. – P. 584-591.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mathiasen A.B., Haack-Sørensen M., Kastrup J. Mesenchymal stromal cells for cardiovascular repair: current status and future challenges // Future Cardiol. – 2009. – Vol. 5, N 6. – Р. 605-17.</mixed-citation><mixed-citation xml:lang="en">Mathiasen A.B., Haack-Sørensen M., Kastrup J. Mesenchymal stromal cells for cardiovascular repair: current status and future challenges // Future Cardiol. – 2009. – Vol. 5, N 6. – Р. 605-17.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">M bius-Winkler S., Hilberg T., Menzel K., Golla E., Burman A., Schuler G., Adams V. Timedependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals // J. Appl. Physiol. – 2009. – Vol. 107, N 6. – P. 1943-50.</mixed-citation><mixed-citation xml:lang="en">M bius-Winkler S., Hilberg T., Menzel K., Golla E., Burman A., Schuler G., Adams V. Timedependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals // J. Appl. Physiol. – 2009. – Vol. 107, N 6. – P. 1943-50.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Morici G., Zangla D., Santoro A., Pelosi E., Petrucci E., Gioia M., Bonanno A., Profita M., Bellia V., Testa U., Bonsignore M.R. Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes // Am. J. Physiol. Regul. Integr. Comp. Physiol. – 2005. – Vol. 289, N 5. – P. 1496-503.</mixed-citation><mixed-citation xml:lang="en">Morici G., Zangla D., Santoro A., Pelosi E., Petrucci E., Gioia M., Bonanno A., Profita M., Bellia V., Testa U., Bonsignore M.R. Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes // Am. J. Physiol. Regul. Integr. Comp. Physiol. – 2005. – Vol. 289, N 5. – P. 1496-503.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Schoenfeld B.J. The mechanisms of muscle hypertrophy and their application to resistance training // J. Strength Cond. Res. – 2010. –Vol. 24, N 10. – Р. 2857-2872.</mixed-citation><mixed-citation xml:lang="en">Schoenfeld B.J. The mechanisms of muscle hypertrophy and their application to resistance training // J. Strength Cond. Res. – 2010. –Vol. 24, N 10. – Р. 2857-2872.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Spiropoulos A., Theodosaki M., Stefanaki K. et al. Rapid clinical-scale propagation of mesenchymal stem cells using cultures initiated with immunoselected bone marrow CD105(+) cells // J. Cell Mol. Med. – 2011. – Vol. 15, N 9. – P. 1983-1988.</mixed-citation><mixed-citation xml:lang="en">Spiropoulos A., Theodosaki M., Stefanaki K. et al. Rapid clinical-scale propagation of mesenchymal stem cells using cultures initiated with immunoselected bone marrow CD105(+) cells // J. Cell Mol. Med. – 2011. – Vol. 15, N 9. – P. 1983-1988.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Van Craenenbroeck E.M., Conraads V.M., Van Bockstaele D.R., Haine S.E., Vermeulen K., Van Tendeloo V.F., Vrints C.J., Hoymans V.Y. Quantification of circulating endothelial progenitor cells: a methodological comparison of six flow cytometric approaches // J. Immunol. Methods. – 2008. – Vol. 332, N (1-2). – Р. 31-40.</mixed-citation><mixed-citation xml:lang="en">Van Craenenbroeck E.M., Conraads V.M., Van Bockstaele D.R., Haine S.E., Vermeulen K., Van Tendeloo V.F., Vrints C.J., Hoymans V.Y. Quantification of circulating endothelial progenitor cells: a methodological comparison of six flow cytometric approaches // J. Immunol. Methods. – 2008. – Vol. 332, N (1-2). – Р. 31-40.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Van Craenenbroeck E.M., Vrints C.J., Haine S.E., Vermeulen K., Goovaerts I., Van Tendeloo V.F., Hoymans V.Y., Conraads V.M. A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile // J. Appl. Physiol. – 2008. – Vol. 104, N 4. – Р. 1006-13.</mixed-citation><mixed-citation xml:lang="en">Van Craenenbroeck E.M., Vrints C.J., Haine S.E., Vermeulen K., Goovaerts I., Van Tendeloo V.F., Hoymans V.Y., Conraads V.M. A maximal exercise bout increases the number of circulating CD34+/KDR+ endothelial progenitor cells in healthy subjects. Relation with lipid profile // J. Appl. Physiol. – 2008. – Vol. 104, N 4. – Р. 1006-13.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Walther M., Herold D., Sinderhauf A., Morrison R. Children sport shoes-a systematic review of current literature // Foot Ankle Surg. – 2008. – Vol. 14, N 4. – P. 180-9.</mixed-citation><mixed-citation xml:lang="en">Walther M., Herold D., Sinderhauf A., Morrison R. Children sport shoes-a systematic review of current literature // Foot Ankle Surg. – 2008. – Vol. 14, N 4. – P. 180-9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.fitness-online.by/2008/08/25/page,2,rabotosposobnost.html</mixed-citation><mixed-citation xml:lang="en">http://www.fitness-online.by/2008/08/25/page,2,rabotosposobnost.html</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.medicinform.net/cardio/cardio_pop6.htm</mixed-citation><mixed-citation xml:lang="en">http://www.medicinform.net/cardio/cardio_pop6.htm</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">http://bestlibraryonline.net/taxonomy/term/3</mixed-citation><mixed-citation xml:lang="en">http://bestlibraryonline.net/taxonomy/term/3</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">http://medbookaide.ru/books/fold1002/book1004/p74.php</mixed-citation><mixed-citation xml:lang="en">http://medbookaide.ru/books/fold1002/book1004/p74.php</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.vera-lab.ru/info/49.html</mixed-citation><mixed-citation xml:lang="en">http://www.vera-lab.ru/info/49.html</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
