<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2010-1-2-21-28</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-35</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ЭКСПРЕССИЯ ТРАНСКРИПЦИОННОГО ФАКТОРА GATA-3 В ЛИМФОЦИТАХ ПЕРИФЕРИЧЕСКОЙ КРОВИ БОЛЬНЫХ БРОНХИАЛЬНОЙ АСТМОЙ</article-title><trans-title-group xml:lang="en"><trans-title>GATA-3 EXPRESSION IN PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH BRONCHIAL ASTHMA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минеев</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mineev</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">minvn@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокина</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokina</surname><given-names>L. N.</given-names></name></name-alternatives><email xlink:type="simple">minvn@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нёма</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nyoma</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">minvn@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimov</surname><given-names>V. I.</given-names></name></name-alternatives><email xlink:type="simple">minvn@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Кафедра госпитальной терапии имени акад. М.В. Черноруцкого Санкт-Петербургского государственного&#13;
медицинского университета имени акад. И.П. Павлова<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>08</day><month>07</month><year>2014</year></pub-date><volume>12</volume><issue>1-2</issue><fpage>21</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Минеев В.Н., Сорокина Л.Н., Нёма М.А., Трофимов В.И., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Минеев В.Н., Сорокина Л.Н., Нёма М.А., Трофимов В.И.</copyright-holder><copyright-holder xml:lang="en">Mineev V.N., Sorokina L.N., Nyoma M.A., Trofimov V.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/35">https://www.mimmun.ru/mimmun/article/view/35</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>Th2-цитокины</kwd><kwd>GATA-3</kwd><kwd>лимфоциты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bronchial asthma</kwd><kwd>Th2-cytokines</kwd><kwd>GATA-3</kwd><kwd>lymphocytes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лимфоциты: методы. / Под ред. Дж. Клауса. – М.: Мир, 1990. – 395 с.</mixed-citation><mixed-citation xml:lang="en">Лимфоциты: методы. / Под ред. Дж. Клауса. – М.: Мир, 1990. – 395 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Минеев В.Н., Сорокина Л.Н. Экспрессия STAT6 в лимфоцитах периферической крови больных аллергической бронхиальной астмой // Медицинская иммунология. – 2007. – Т. 9, № 4-5. – С. 405-410.</mixed-citation><mixed-citation xml:lang="en">Минеев В.Н., Сорокина Л.Н. Экспрессия STAT6 в лимфоцитах периферической крови больных аллергической бронхиальной астмой // Медицинская иммунология. – 2007. – Т. 9, № 4-5. – С. 405-410.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Минеев В.Н., Сорокина Л.Н., Нёма М.А. Влияние IL-4 на активность транскрипционного фактора STAT6 в лимфоцитах периферической крови больных бронхиальной астмой // Медицинская иммунология. – 2009. – Т. 11, № 2-3. –С. 177-184.</mixed-citation><mixed-citation xml:lang="en">Минеев В.Н., Сорокина Л.Н., Нёма М.А. Влияние IL-4 на активность транскрипционного фактора STAT6 в лимфоцитах периферической крови больных бронхиальной астмой // Медицинская иммунология. – 2009. – Т. 11, № 2-3. –С. 177-184.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Фрейдлин И.С., Тотолян А.А. Иммунологические механизмы аллергических реакций /Общая аллергология. Т. 1. – СПб.: Нордмед-Издат, 2001. – C. 169-381.</mixed-citation><mixed-citation xml:lang="en">Фрейдлин И.С., Тотолян А.А. Иммунологические механизмы аллергических реакций /Общая аллергология. Т. 1. – СПб.: Нордмед-Издат, 2001. – C. 169-381.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Arakawa S., Hatano Y., Katagiri K. Differential expression of mRNA for Th1 and Th2 cytokineassociated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis // J. Clin. Exp. Immunol. – 2004. – Vol. 135. – P. 505-510.</mixed-citation><mixed-citation xml:lang="en">Arakawa S., Hatano Y., Katagiri K. Differential expression of mRNA for Th1 and Th2 cytokineassociated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis // J. Clin. Exp. Immunol. – 2004. – Vol. 135. – P. 505-510.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Asthma feature: Mechanisms in COPD compared with asthma // Breathe. – 2008. – Vol. 5, N 2. – P. 134-144.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Asthma feature: Mechanisms in COPD compared with asthma // Breathe. – 2008. – Vol. 5, N 2. – P. 134-144.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Role of GATA-3 in allergic diseases // Curr. Mol. Med. – 2008. – Vol. 8, N 5. –P. 330-334.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Role of GATA-3 in allergic diseases // Curr. Mol. Med. – 2008. – Vol. 8, N 5. –P. 330-334.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Caramori G., Lim S., Ito K., Tomita K., Oates T., Jazrawi E., Chung K.F., Barnes P.J., Adcock I.M. Expression of GATA family of transcription factors in T cells, monocytes and bronchial biopsies // Eur. Respir. J. – 2001. – Vol. 18. – P. 466-473.</mixed-citation><mixed-citation xml:lang="en">Caramori G., Lim S., Ito K., Tomita K., Oates T., Jazrawi E., Chung K.F., Barnes P.J., Adcock I.M. Expression of GATA family of transcription factors in T cells, monocytes and bronchial biopsies // Eur. Respir. J. – 2001. – Vol. 18. – P. 466-473.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cornejo-Garcia J. A., Fernandez T. D.,Torres M. J., Carballo M., Hernan I., Antunez C., Blanca M., Mayorga C. Differential cytokine and transcription factor expression in patients with allergic reactions to drugs // Allergy. – 2007. – Vol. 62, N 12. – P. 1429 - 1438.</mixed-citation><mixed-citation xml:lang="en">Cornejo-Garcia J. A., Fernandez T. D.,Torres M. J., Carballo M., Hernan I., Antunez C., Blanca M., Mayorga C. Differential cytokine and transcription factor expression in patients with allergic reactions to drugs // Allergy. – 2007. – Vol. 62, N 12. – P. 1429 - 1438.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Eman M., Manal E., Hoda B., Dalia E. GATA- 3 mRNA expression in bronchial asthma.Effect of inhaled corticosteroid therapy // Tanta Medical Sciences Journal. – 2007. – Vol. 2, N 2. –P. 5-15.</mixed-citation><mixed-citation xml:lang="en">Eman M., Manal E., Hoda B., Dalia E. GATA- 3 mRNA expression in bronchial asthma.Effect of inhaled corticosteroid therapy // Tanta Medical Sciences Journal. – 2007. – Vol. 2, N 2. –P. 5-15.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Finotto S., De Sanctis G.T., Lehr H.A., Herz U., Buerke M., Schipp M., Bartsch B., Atreya R., Schmitt E., Galle P.R., H. Renz H., Neurath M.F. Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-induced Local Blockade of GATA-3 Expression // J. Exp. Med. – 2001. – Vol. 193, N 11. – P. 1247-1260.</mixed-citation><mixed-citation xml:lang="en">Finotto S., De Sanctis G.T., Lehr H.A., Herz U., Buerke M., Schipp M., Bartsch B., Atreya R., Schmitt E., Galle P.R., H. Renz H., Neurath M.F. Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-induced Local Blockade of GATA-3 Expression // J. Exp. Med. – 2001. – Vol. 193, N 11. – P. 1247-1260.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Frederic F. Little, David M. Center. Induced sputum analysis for T-helper type 2 cell regulation // Chest. – 2003. – 123. – P. 1786-1788.</mixed-citation><mixed-citation xml:lang="en">Frederic F. Little, David M. Center. Induced sputum analysis for T-helper type 2 cell regulation // Chest. – 2003. – 123. – P. 1786-1788.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Georas S.N. Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases // Proc. Am. Thorac. Soc. – 2004. –Vol. 1. – P. 215-221.</mixed-citation><mixed-citation xml:lang="en">Georas S.N. Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases // Proc. Am. Thorac. Soc. – 2004. –Vol. 1. – P. 215-221.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Georas S.N., Guo J., De Fanis U., Casolaro V. T-helper cell type-2 regulation in allergic disease // Eur. Respir. J. – 2005. – Vol. 26. – P. 1119-1137.</mixed-citation><mixed-citation xml:lang="en">Georas S.N., Guo J., De Fanis U., Casolaro V. T-helper cell type-2 regulation in allergic disease // Eur. Respir. J. – 2005. – Vol. 26. – P. 1119-1137.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hayashi R., Wada H., Ito K., Adcock I.M. Effects of glucocorticoids on gene transcription // Eur. J. Pharmacology. – 2004. – Vol. 500, N 1-3. –P. 51-62.</mixed-citation><mixed-citation xml:lang="en">Hayashi R., Wada H., Ito K., Adcock I.M. Effects of glucocorticoids on gene transcription // Eur. J. Pharmacology. – 2004. – Vol. 500, N 1-3. –P. 51-62.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang E.S., Szabo S.J., Schwartzberg P.L.,Glimcher L.H. T-helper cell fate specified by kinasemediated interaction of T-bet with GATA-3 // Science. – 2005. – Vol. 307. – P. 430-433.</mixed-citation><mixed-citation xml:lang="en">Hwang E.S., Szabo S.J., Schwartzberg P.L.,Glimcher L.H. T-helper cell fate specified by kinasemediated interaction of T-bet with GATA-3 // Science. – 2005. – Vol. 307. – P. 430-433.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kay A.B. The role of T lymphocytes in asthma // Chem. Immunol. Allergy. – 2006. –Vol. 91. – P. 59- 75.</mixed-citation><mixed-citation xml:lang="en">Kay A.B. The role of T lymphocytes in asthma // Chem. Immunol. Allergy. – 2006. –Vol. 91. – P. 59- 75.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kowalski M. L., Alam R.. Signal transduction mechanisms as new targets for allergists // J. Allergy. – 2001. – Vol. 56. – P. 199-203.</mixed-citation><mixed-citation xml:lang="en">Kowalski M. L., Alam R.. Signal transduction mechanisms as new targets for allergists // J. Allergy. – 2001. – Vol. 56. – P. 199-203.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kurata H., Lee H.J., O’Garra A., Arai N. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1-cells //Immunity. – 1999. – Vol. 11. – P. 677-688.</mixed-citation><mixed-citation xml:lang="en">Kurata H., Lee H.J., O’Garra A., Arai N. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1-cells //Immunity. – 1999. – Vol. 11. – P. 677-688.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Maneechotesuwan K., Xin Y., Ito K., Jazrawi E., Lee K.-Y., Usmani O.S., Barnes P.J., Adcock I.M. Regulation of Th2 Cytokine Genes by p38 MAPKMediated Phosphorylation of GATA - 3 // The Journal of Immunology. – 2007. – Vol. 178. – P. 2491-2498.</mixed-citation><mixed-citation xml:lang="en">Maneechotesuwan K., Xin Y., Ito K., Jazrawi E., Lee K.-Y., Usmani O.S., Barnes P.J., Adcock I.M. Regulation of Th2 Cytokine Genes by p38 MAPKMediated Phosphorylation of GATA - 3 // The Journal of Immunology. – 2007. – Vol. 178. – P. 2491-2498.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mantel P.-Y., Kuipers H., Boyman O., Rhyner C., Ouaked N., Ruckert B., Karagiannidis Ch., Lambrecht B.N., Hendriks R.W.,Crameri R., Akdis C.A., Blaser K., Schmidt- Weber C.B. GATA - 3- Driven Th2 ResponsesInhibit TGF-b1-Induced FOXP3 Expression and the Formation of Regulatory T Cells // J. PLoS. Biology. – 2007. – Vol. 5, N 12. – P. 2847-2861.</mixed-citation><mixed-citation xml:lang="en">Mantel P.-Y., Kuipers H., Boyman O., Rhyner C., Ouaked N., Ruckert B., Karagiannidis Ch., Lambrecht B.N., Hendriks R.W.,Crameri R., Akdis C.A., Blaser K., Schmidt- Weber C.B. GATA - 3- Driven Th2 ResponsesInhibit TGF-b1-Induced FOXP3 Expression and the Formation of Regulatory T Cells // J. PLoS. Biology. – 2007. – Vol. 5, N 12. – P. 2847-2861.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Nakamura Y., Hoshino M. Th2-cytokines and associated transcription factors as therapeutic targets in asthma // Curr. Drug Targets Inflamm. Allergy. –2005. – Vol. 4, N 2. – P. 267-270.</mixed-citation><mixed-citation xml:lang="en">Nakamura Y., Hoshino M. Th2-cytokines and associated transcription factors as therapeutic targets in asthma // Curr. Drug Targets Inflamm. Allergy. –2005. – Vol. 4, N 2. – P. 267-270.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Roth M., Black J.L. Transcription factors in asthma: are transcription factors a new target for asthma therapy? // Curr. Drug Targets. – 2006. – Vol.7, N 5. – P. 589-595.</mixed-citation><mixed-citation xml:lang="en">Roth M., Black J.L. Transcription factors in asthma: are transcription factors a new target for asthma therapy? // Curr. Drug Targets. – 2006. – Vol.7, N 5. – P. 589-595.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Sel S., Henke W., Dietrich A., Herz U., Renz H. Treatment of allergic asthma by targeting transcription factors using nucleic-acid based technologies // Curr. Pharm. Des. – 2006. – Vol. 12, N 25. – P. 3293- 3304.</mixed-citation><mixed-citation xml:lang="en">Sel S., Henke W., Dietrich A., Herz U., Renz H. Treatment of allergic asthma by targeting transcription factors using nucleic-acid based technologies // Curr. Pharm. Des. – 2006. – Vol. 12, N 25. – P. 3293- 3304.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Taha R., Hamid Q., Cameron L., Olivenstein R. T-helper type 2 cytokine receptors and associated transcription factors GATA-3, c-MAF, and signal transducer and activator of transcription factor-6 in induced sputum of atopic asthmatic patients // Chest. – 2003. – Vol. 123. – P. 2074-2082.</mixed-citation><mixed-citation xml:lang="en">Taha R., Hamid Q., Cameron L., Olivenstein R. T-helper type 2 cytokine receptors and associated transcription factors GATA-3, c-MAF, and signal transducer and activator of transcription factor-6 in induced sputum of atopic asthmatic patients // Chest. – 2003. – Vol. 123. – P. 2074-2082.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tamauchi H., Terashima M., Ito M. Maruyama H., Ikewaki N., Inoue M., Iuhua Gao X., Hozumi K., Habu S. Evidence of GATA - 3-dependent Th2 commitment during the in vivo immune response // International Immunology. – 2004. – Vol. 16, N 1. – P. 179-187.</mixed-citation><mixed-citation xml:lang="en">Tamauchi H., Terashima M., Ito M. Maruyama H., Ikewaki N., Inoue M., Iuhua Gao X., Hozumi K., Habu S. Evidence of GATA - 3-dependent Th2 commitment during the in vivo immune response // International Immunology. – 2004. – Vol. 16, N 1. – P. 179-187.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Usui T., Preiss J.C., Kanno Y., Yao Z.J., Bream J.H. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFN-G gene acetylation and transcription // J. Exp. Med. – 2006. – Vol. 203. – P. 755-766.</mixed-citation><mixed-citation xml:lang="en">Usui T., Preiss J.C., Kanno Y., Yao Z.J., Bream J.H. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFN-G gene acetylation and transcription // J. Exp. Med. – 2006. – Vol. 203. – P. 755-766.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Yamashita N., Tashimo H., Ishida H., Matsuo Y., Tamauchi H. Involvement of GATA - 3-dependent Th2 lymphocyte activation in airway hyperresponsiveness // Am. J. Physiol. Lung. Cell. Mol. Physiol. – 2006. – Vol. 290. – P. 1045-1051.</mixed-citation><mixed-citation xml:lang="en">Yamashita N., Tashimo H., Ishida H., Matsuo Y., Tamauchi H. Involvement of GATA - 3-dependent Th2 lymphocyte activation in airway hyperresponsiveness // Am. J. Physiol. Lung. Cell. Mol. Physiol. – 2006. – Vol. 290. – P. 1045-1051.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu J., Yamane H., Cote-Sierra J., Guo L., Paul W.E. GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2- cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors // Cell. Res. – 2006. – Vol. 16. – P. 3-10.</mixed-citation><mixed-citation xml:lang="en">Zhu J., Yamane H., Cote-Sierra J., Guo L., Paul W.E. GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2- cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors // Cell. Res. – 2006. – Vol. 16. – P. 3-10.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
