mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2012-3-183-188mimmun-344Research ArticleОБЗОРЫREVIEWSГУМОРАЛЬНЫЙ ИММУННЫЙ ОТВЕТ НА ВИЧ-ИНФЕКЦИЮ И НАРУШЕНИЕ ФУНКЦИЙ В-ЛИМФОЦИТОВHUMORAL IMMUNE RESPONSE TO HIV-1 INFECTION AND ALTERED FUNCTION OF B LYMPHOCYTESКетлинскийС. А.KetlinskyS. A.

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ketlinsky@hpb-spb.comФГУП «Гос.НИИ ОЧБ» ФМБА России, Санкт-ПетербургRussian Federation201220072014143183188Copyright © Кетлинский С.А., 20142014Кетлинский С.А.Ketlinsky S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/344

Резюме. В последние годы интенсивные исследования были посвящены выяснению механизмов патогенеза прогрессии ВИЧ-ассоциированной болезни. В дополнение к прогрессивному снижению и дисфункции CD4+Т-клеток, ВИЧ-инфекция также ведет к интенсивным дефектам гуморального звена иммунной системы. Отсутствие иммунного контроля вируса, приводящее к инфицированию, является большим препятствием к лечению этого заболевания и успешному созданию вакцины против ВИЧ-инфекции. Данный обзор посвящен описанию гуморального иммунитета и нарушению функции В-лимфоцитов, которые меньше всего изучены в патогенезе ВИЧ-инфекции.

Abstract. Over past years, extensive studies were dedicated to pathogenetic mechanisms of HIV-associated disease. In addition to progressive decrease and dysfunction of CD4+T cells, HIV-1 infection also causes intensive defects of humoral immune links. Absence of antiviral immune control leads to infection, and this presents great obstacles when treating the disease and developing an effective vaccine against HIV-1 infection. This review article concerns some features of humoral immunity and disturbed B lymphocyte functions that are studied to lesser degree, with respect to HIV infection pathogenesis.

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The authors declare that there are no conflicts of interest present.