mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-IIT-3335mimmun-3335Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИНТЕРЛЕЙКИН-1β В ПЕРИФЕРИЧЕСКОЙ КРОВИ У БЕРЕМЕННЫХ ЖЕНЩИН В ПЕРИОД ОСТРОЙ ИНФЕКЦИИ SARS-COV-2 С ЛЕГКИМ И СРЕДНЕТЯЖЕЛЫМ ТЕЧЕНИЕМINTERLEUKIN-1β IN THE BLOOD OF PREGNANT WOMEN WITH ACUTE SARS-COV-2 INFECTION WITH MILD AND MODERATE ILLNESShttps://orcid.org/0000-0002-5603-490XЗновецТ. В.ZnovetsT. V.

заместитель главного врача по родовспоможению; ведущий научный сотрудник

 

Ph.D. (Medicine), Deputy Chief Physician for Obstetrics; Leading Researcher

znota@mail.ruhttps://orcid.org/0000-0002-2116-4675БарановскаяЕ. И.BaranouskayaA. I.

доктор медицинских наук, профессор, профессор кафедры акушерства и гинекологии с курсом повышения квалификации и переподготовки

 

Ph.D., MD (Medicine), Professor, Professor of the Department of Obstetrics and Gynecology with a course for advanced training and retraining, Educational Institution «Belarusian State Medical University», Minsk, Republic of Belarus

elena_baranovska@mail.ruСаевичН. И.SaevichN. I.

главный врач

Chief Physician, Healthcare Institution «3rd City Clinical Hospital named after E.V. Klumov», Minsk, Republic of Belarus

info@3gkb.byГорбичО. А.GorbichO. A.

кандидат медицинских наук, доцент, заведующий клинико-диагностической лабораторией

Ph.D. (Medicine), Associate Professor, Head of the Clinical Diagnostic Laboratory, Healthcare Institution «3rd City Clinical Hospital named after E.V. Klumov», Minsk, Republic of Belarus

info@3gkb.byБеляткоЕ. В.BelyatkoE. V.

врач-акушер-гинеколог 

obstetrician-gynecologist, Healthcare Institution «3rd City Clinical Hospital named after E.V. Klumov», Minsk, Republic of Belarus

info@3gkb.byУчреждение здравоохранения «3-я городская клиническая больница им. Е. В. Клумова», Минск, Беларусь; Учреждение образования «Белорусский государственный медицинский университет», Минск, БеларусьБеларусьHealthcare Institution «3rd City Clinical Hospital named after E.V. Klumov», Minsk, Republic of Belarus; Educational Institution «Belarusian State Medical University», Minsk, Republic of BelarusBelarusУчреждение образования «Белорусский государственный медицинский университет», Минск, БеларусьБеларусьEducational Institution «Belarusian State Medical University», Minsk, Republic of BelarusBelarusУчреждение здравоохранения «3-я городская клиническая больница им. Е. В. Клумова», Минск, БеларусьБеларусьHealthcare Institution «3rd City Clinical Hospital named after E.V. Klumov», Minsk, Republic of BelarusBelarus20190608202600Online First3335Copyright © Зновец Т.В., Барановская Е.И., Саевич Н.И., Горбич О.А., Белятко Е.В., 20192019Зновец Т.В., Барановская Е.И., Саевич Н.И., Горбич О.А., Белятко Е.В.Znovets T.V., Baranouskaya A.I., Saevich N.I., Gorbich O.A., Belyatko E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/3335

Беременные женщины уязвимы для воздействия SARS-CoV-2 из-за физиологических особенностей иммунной системы. Цель исследования: оценить значение интерлейкина-1β (IL-1β) периферической крови у беременных женщин в период инфекции SARS-CoV-2 при легкой и среднетяжелой форме болезни. В исследование включено 60 беременных женщин с COVID-19, среди которых 14 женщин в I триместре, 17 – во II триместре и 29 – в III триместре. Группу сравнения составили 20 беременных женщин без клинико-лабораторных признаков острых респираторных инфекций. Концентрацию IL-1β определяли в сыворотке крови методом иммуноферментного анализа. Для статистической обработки данных применяли программу Statistica 10.0 (StatSoft, США). Статистически значимым уровнем ошибки считали p≤0,05. Результаты исследования показали выше уровень IL-1β в крови SARS-CoV-2-инфицированных беременных женщин в сравнение с беременными женщинами без клинико-лабораторных признаков острых респираторных инфекций (p=0,005). COVID-19 характеризуется снижением уровня IL-1β в крови в III триместре гестации в сравнении с I триместром (p=0,01). Беременные женщины с COVID-19 в сравнении с беременными женщинами без клинико-лабораторных признаков острых респираторных инфекций имели выше показатели в крови эритроцитов (p=0,043), общего белка (p=0,006), прямого билирубина (p=0,02), С-реактивного белка высокочувствительного (p<0,001), ферритина (p=0,016), протромбинового времени (p=0,018) и международного нормализованного отношения (p=0,013). При COVID-19 у беременных женщин в крови ниже уровень лимфоцитов (p=0,004), сывороточного железа (p<0,001) и трансферрина (p=0,003), показатели коэффициента насыщения трансферрина (p=0,026) и общей железосвязывающей способности сыворотки (p=0,021). IL-1β в крови у SARS-CoV-2-инфицированных беременных имел обратную корреляционную связь с биохимическими и коагуляционными показателями крови: трансферрин (p=0,006), общая железосвязывающая способность сыворотки (p=0,03), латентная железосвязывающая способность сыворотки (p=0,009), фибриноген (p=0,002). IL-1β в крови у SARS-CoV-2-инфицированных беременных ассоциирован с уровнем прямого билирубина (p=0,045) при среднетяжелой форме COVID-19, С-реактивного белка (p=0,047) и аланинаминотрансферазы (p=0,024) при легкой форме болезни. Среднетяжелая форма COVID-19 у беременных женщин ассоциирована со снижением уровня лейкоцитов (p=0,038) и удлинением протромбинового времени (p=0,046). Таким образом, установлена связь концентрации в крови IL-1β с коагуляционными и биохимическими показателями у женщин с COVID-19 в разные сроки беременности и в зависимости от клинического течения COVID-19.

Pregnant women are vulnerable to SARS-CoV-2 infection due to physiological features of the immune system. The aim of the research was to evaluate the levels of interleukin-1β (IL-1β) in the peripheral blood of pregnant women during SARS-CoV-2 infection with mild to moderate forms of the disease. We examined 60 pregnant women with COVID-19, including 14 women in the first trimester, 17 in the second trimester, and 29 in the third trimester. The comparison group consisted of 20 pregnant women without clinical and laboratory signs of acute respiratory infections. IL-1β concentrations were determined in serum using enzyme-linked immunosorbent assay. Statistica 10.0 (StatSoft, USA) was used for statistical data processing. The statistically significant error level was considered to be p≤0.05. The study results showed higher levels of IL-1β in the blood of SARS-CoV-2-infected pregnant women compared to pregnant women without clinical and laboratory evidence of acute respiratory infections (p=0.005). COVID-19 is characterized by a decrease in the level of IL-1β in the blood in the third trimester of gestation compared to the first trimester (p=0.01). Pregnant women with COVID-19, compared with pregnant women without clinical and laboratory signs of acute respiratory infections, had higher levels of red blood cells (p=0.043), total protein (p=0.006), direct bilirubin (p=0.02), high-sensitivity C-reactive protein (p<0.001), ferritin (p=0.016), prothrombin time (p=0.018) and international normalized ratio (p=0.013). COVID-19 in pregnant women is associated with lower levels of lymphocytes (p=0.004), serum iron (p<0.001) and transferrin (p=0.003), transferrin saturation coefficient (p=0.026) and total iron-binding capacity of serum (p=0.021) in the blood. IL-1β in SARS-CoV-2-infected pregnant women had an inverse correlation with biochemical and coagulation blood parameters: transferrin (p=0.006), total iron-binding capacity of serum (p=0.03), latent iron-binding capacity of serum (p=0.009), fibrinogen (p=0.002). IL-1β in the blood of SARS-CoV-2-infected pregnant women is associated with the level of direct bilirubin (p=0.045) in moderate COVID-19, C-reactive protein (p=0.047) and alanine aminotransferase (p=0.024) in mild forms of the disease. Moderate COVID-19 in pregnant women is associated with a decrease of  leukocyte count (p=0.038) and an increase in prothrombin time (p=0.046). Thus, a relationship was established between the concentration of IL-1β in the blood and coagulation and biochemical parameters in women with COVID-19 at different stages of pregnancy and depending on the clinical course of COVID-19.

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The authors declare that there are no conflicts of interest present.