mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-IOP-3256mimmun-3256Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВлияние полиморфных вариантов rs10455025 гена TSLP и rs11811856 гена TNFSF4 на риск развития атопической бронхиальной астмы и аллергических реакций у детейInfluence of polymorphic variants rs10455025 of TSLP and rs11811856 of the TNFSF4 gene on the risk of atopic bronchial asthma and allergy in childrenhttps://orcid.org/0000-0002-0283-2498СерёжкинаА. В.SerezhkinaA. V.

Серёжкина Александра Владимировна – ассистент кафедры педиатрии.

305041, Курск, ул. К. Маркса, 3. Тел.: 8 (919) 171-00-46

Aleksandra V. Serezhkina - Assistant Professor, Department of Pediatrics

3 K. Marx St Kursk 305041 Phone: +7 (919) 171-00-46

aleksandra.ykv@gmail.comhttps://orcid.org/0000-0003-3333-0623БушуеваО. Ю.BushuevaO. Yu.

д.м.н., заведующая лабораторией геномных исследований Научно-исследовательского института генетической и молекулярной эпидемиологии, профессор кафедры биологии, медицинской генетики и экологии.

Курск

PhD, MD (Medicine), Head of the Laboratory Genomic Research, Research Institute of Genetic and Molecular Epidemiology, Professor of the Department of Biology, Medical Genetics and Ecology.

Kursk

olga.bushueva@inbox.ruhttps://orcid.org/0000-0002-4636-1819БогомазовА. Д.BogomazovA. D.

к.м.н., доцент кафедры педиатрии.

Курск

PhD (Medicine), Associate Professor, Department of Pediatrics.

Kursk

bogomazov71@mail.ruhttps://orcid.org/0000-0001-6280-247XПолониковА. В.PolonikovA. V.

д.м.н., директор Научно-исследовательского института генетической и молекулярной эпидемиологии, профессор кафедры биологии, медицинской генетики и экологии.

Курск

PhD, MD (Medicine), Director of the Research Institute of Genetic and Molecular Epidemiology, Professor of the Department of Biology, Medical Genetics and Ecology.

Kursk

polonikov@rambler.ruФГБОУ ВО «Курский государственный медицинский университет»РоссияKursk State Medical UniversityRussian Federation2026140220262814352Copyright © Серёжкина А.В., Бушуева О.Ю., Богомазов А.Д., Полоников А.В., 20262026Серёжкина А.В., Бушуева О.Ю., Богомазов А.Д., Полоников А.В.Serezhkina A.V., Bushueva O.Y., Bogomazov A.D., Polonikov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/3256

Имеющиеся на сегодняшний день экспериментальные данные указывают на определяющую роль цитокинов в формировании проявлений бронхиальной астмы (БА), что привело к созданию так называемого антицитокинового подхода к терапии данного заболевания [5]. Целью данного исследования было определить вклад полиморфизмов rs10455025 гена TSLP и rs11811856 гена TNFSF4 с риском развития БА у детей в курской популяции. В исследование были включены 999 неродственных индивидуумов, включая 526 пациентов с БА и 473 контрольных лица. Данные функциональные однонуклеотидные полиморфизмы (SNP) были генотипированы на геномном масс-спектрометре MassArray-4. Установлено, что аллели rs11811856G TNFSF4 и rs10455025C TSLP, а также генотипы rs11811856-G/G и rs10455025-C/C ассоциированы с повышенным риском развития БА у детей. Выявлена ассоциация rs11811856 TNFSF4 с повышенным риском развития БА как среди мальчиков, так и девочек, а полиморфизм rs10455025 TSLP при стратифицированном анализе по полу ассоциаций не показал. При анализе генно-средовых взаимодействий в общей группе установлена взаимосвязь с риском астмы в зависимости от воздействия табачного дыма и места проживания детей. Установлено влияние данных SNP на риск формирования сопутствующей аллергопатологии у детей с БА, также установлено влияние исследуемых полиморфизмов на показатели риноцитограммы и спирометрии. В ходе исследования получены данные, что исследуемые полиморфизмы rs10455025 TSLP и rs11811856 TNFSF4 у детей с БА связаны с повышенным риском развития пищевой сенсибилизации к банану, рису, утке, ряду пыльцевых (лисохвост, ежа сборная, мятлик, райграс, костер, ясень, ячмень) и эпидермальных (волос человека) аллергенов. Также выявлено, что исследуемые SNP снижают риск сенсибилизации к домашней пыли, шерсти кошки, кролика, пыльце киноа. Настоящее исследование показало, что полиморфизмы rs10455025 TSLP и rs11811856 TNFSF4 в значительной степени связаны с риском развития астмы и с его клиническими особенностями.

Current experimental data indicate the leading role of cytokines in the formation of manifestations of bronchial asthma (BA), thus supporting the so-called anti-cytokine approach to the therapy of this disease. The aim of this study was to evaluate possible association of rs10455025 TSLP gene variant and rs11811856 polymorphism of TNFSF4 gene with the risk of developing BA among children from Kursk population. The study included 999 unrelated individuals, including 526 patients with BA and 473 control persons. These functional gene polymorphisms (SNPs) were genotyped using the MassArray-4 genomic mass spectrometer. We have found that the alleles rs11811856G TNFSF4 and rs10455025C TSLP, as well as the genotypes rs11811856G/G and rs10455025-C/C are associated with an increased risk of developing BA in children. The association of rs11811856 TNFSF4 with an increased risk of developing BA was revealed in both boys and girls. Meawhile, the rs10455025 polymorphism of TSLP gene did not show any associations in the stratified analysis by gender. Upon analysis of gene-environment interactions in general group, a relationship was established with the risk of asthma depending on exposure to tobacco smoke and the place of residence of children. We have found a relationship between the SNP status and the risk of concomitant allergopathology in children with BA, and the influence of the studied polymorphisms on laboratory indices of rhinocytogram and spirometry. The results of this study have shown that the studied SNPs (rs10455025 TSLP and rs11811856 TNFSF4) in children with BA are associated with increased risk of developing food sensitization to banana, rice, duck, and a number of pollen (foxtail, common horsetail, bluegrass, ryegrass, fireweed, ash, barley), and epidermal (human hair) allergens. It has also been found that the studied SNPs reduce the risk of sensitization to house dust, cat hair, rabbit hair, and quinoa pollen. The present study showed that the polymorphic gene variants (rs10455025 TSLP and rs11811856 TNFSF4) are significantly associated with the risk and clinical features of developing BA.

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The authors declare that there are no conflicts of interest present.