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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2012-1-2-163-168</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-325</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SHORT COMMUNICATIONS</subject></subj-group></article-categories><title-group><article-title>ИНТЕНСИВНОСТЬ ТИМОПОЭЗА У ПАЦИЕНТОВ С БРОНХИАЛЬНОЙ АСТМОЙ В ЗАВИСИМОСТИ ОТ ДЛИТЕЛЬНОСТИ ЗАБОЛЕВАНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>THYMOPOIESIS INTENSITY IN PATIENTS WITH BRONCHIAL ASTHMA, DEPENDING ON DURATION OF THE DISEASE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>630099, г. Новосибирск, ул. Ядринцевская, 14. Тел.: (383) 228-21-20. Факс: (383) 222-70-28.</p></bio><email xlink:type="simple">blinovaelena-85@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Непомнящих</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nepomniashchikh</surname><given-names>V. M.</given-names></name></name-alternatives><email xlink:type="simple">blinovaelena-85@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кожевников</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozhevnikov</surname><given-names>V. S.</given-names></name></name-alternatives><email xlink:type="simple">blinovaelena-85@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НИИ клинической иммунологии СО РАМН, г. Новосибирск<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2014</year></pub-date><volume>14</volume><issue>1-2</issue><fpage>163</fpage><lpage>168</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Блинова Е.А., Непомнящих В.М., Кожевников В.С., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Блинова Е.А., Непомнящих В.М., Кожевников В.С.</copyright-holder><copyright-holder xml:lang="en">Blinova E.A., Nepomniashchikh V.M., Kozhevnikov V.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/325">https://www.mimmun.ru/mimmun/article/view/325</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>тимопоэз</kwd><kwd>TREC</kwd><kwd>Т-лимфоциты</kwd><kwd>бронхиальная астма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thymopoiesis</kwd><kwd>TREC</kwd><kwd>T lymphocytes</kwd><kwd>bronchial asthma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Борисов В.И., Демаков С.А., Непомнящих В.М., Леонова М.И., Демина Д.В., Баровская Н.А., Кожевников В.С. Особенности изменения средней длины теломер в лимфоцитах у больных бронхиальной астмой // Медицинская Иммунология. – 2009. – Т. 11, № 6. – C. 523-530.</mixed-citation><mixed-citation xml:lang="en">Борисов В.И., Демаков С.А., Непомнящих В.М., Леонова М.И., Демина Д.В., Баровская Н.А., Кожевников В.С. Особенности изменения средней длины теломер в лимфоцитах у больных бронхиальной астмой // Медицинская Иммунология. – 2009. – Т. 11, № 6. – C. 523-530.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen J.J. Glucocorticoid-induced apoptosis in the thymus // Semin. Immunol. – 1992. – Vol. 6. – P. 363-369.</mixed-citation><mixed-citation xml:lang="en">Cohen J.J. Glucocorticoid-induced apoptosis in the thymus // Semin. Immunol. – 1992. – Vol. 6. – P. 363-369.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Demoly P, Chanez P, Pujol J.L. Fos immunoreactivity assessment on human normal and pathological bronchial biopsies // Raspir. Med. – 1995. – 89. – P. 329-335.</mixed-citation><mixed-citation xml:lang="en">Demoly P, Chanez P, Pujol J.L. Fos immunoreactivity assessment on human normal and pathological bronchial biopsies // Raspir. Med. – 1995. – 89. – P. 329-335.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Douek D.C., McFarland R.D., Keiser P.H., Gaqe E.A. Massey J.M., Haynes B.F., Polis M.A., Haase A.T., Feinberg M.B., Sullivan J.L., Jamieson B.D., Zack J.A., Picker L.J., Koup R.A. Changes ih thymic function with age and during the treatment of HIV infection // Nature. – 1998. – Vol. 396. – P. 690-695.</mixed-citation><mixed-citation xml:lang="en">Douek D.C., McFarland R.D., Keiser P.H., Gaqe E.A. Massey J.M., Haynes B.F., Polis M.A., Haase A.T., Feinberg M.B., Sullivan J.L., Jamieson B.D., Zack J.A., Picker L.J., Koup R.A. Changes ih thymic function with age and during the treatment of HIV infection // Nature. – 1998. – Vol. 396. – P. 690-695.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gauzzi V., Aiuti F., Mezzaroma I., Mazzetta F., Andolfi G., Mortellaro A., Pierdomonici M., Fantini R., Marziali M., Aiuti A. Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles // Clin. Exp. Immunol. – 2002. – Vol. 192. – P. 346-353.</mixed-citation><mixed-citation xml:lang="en">Gauzzi V., Aiuti F., Mezzaroma I., Mazzetta F., Andolfi G., Mortellaro A., Pierdomonici M., Fantini R., Marziali M., Aiuti A. Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles // Clin. Exp. Immunol. – 2002. – Vol. 192. – P. 346-353.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">He R. and Geha R.S. Thymic stromal lymphopoietin // Ann. N.Y. Acad. Sci. – 2010. – Vol. 1183. – P. 13-24.</mixed-citation><mixed-citation xml:lang="en">He R. and Geha R.S. Thymic stromal lymphopoietin // Ann. N.Y. Acad. Sci. – 2010. – Vol. 1183. – P. 13-24.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hosseinzadeh H., Goldschneider I. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues // J. Immunol. – 1993. – Vol. 150, N 5. – P. 1670-1679.</mixed-citation><mixed-citation xml:lang="en">Hosseinzadeh H., Goldschneider I. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues // J. Immunol. – 1993. – Vol. 150, N 5. – P. 1670-1679.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hug A., Korporal M., Shroder I., Haas J., Glatz K., Storch-Hagenlocher B., Wildemann B. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis // J. Immunol. – 2003. – Vol. 171. – P. 432-437.</mixed-citation><mixed-citation xml:lang="en">Hug A., Korporal M., Shroder I., Haas J., Glatz K., Storch-Hagenlocher B., Wildemann B. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis // J. Immunol. – 2003. – Vol. 171. – P. 432-437.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kay A.B. Allergy and allergic diseases – first of two parts // Engl. J. Med. – 2001. – Vol. 344. – P. 30-37.</mixed-citation><mixed-citation xml:lang="en">Kay A.B. Allergy and allergic diseases – first of two parts // Engl. J. Med. – 2001. – Vol. 344. – P. 30-37.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Koetz K., Bryl E., Spickschen K., O’Fallon W.M., Goronzy J.J., Weyand C.M. T cell homeostasis in patient with rheumatoid arthritis // PNAS. – 2000. – Vol. 97, N 16. – P. 9203-9208.</mixed-citation><mixed-citation xml:lang="en">Koetz K., Bryl E., Spickschen K., O’Fallon W.M., Goronzy J.J., Weyand C.M. T cell homeostasis in patient with rheumatoid arthritis // PNAS. – 2000. – Vol. 97, N 16. – P. 9203-9208.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kohler S., Thiel A. Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets // Blood – 2009. – Vol. 113, N 2. – P. 769-774.</mixed-citation><mixed-citation xml:lang="en">Kohler S., Thiel A. Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets // Blood – 2009. – Vol. 113, N 2. – P. 769-774.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Konq F., Chen C.H., Cooper M.D. Thymic function can be monitored by the level of recent T cell emigrants in the circulation // Immunity. – 1998. – Vol. 8, N 1. – P. 97-104.</mixed-citation><mixed-citation xml:lang="en">Konq F., Chen C.H., Cooper M.D. Thymic function can be monitored by the level of recent T cell emigrants in the circulation // Immunity. – 1998. – Vol. 8, N 1. – P. 97-104.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Livak F., Schatz D.G. T-cell receptor α locus V(D)J recombination by-products are abundant in thymocytes and mature T cells // Mol. Cell. Biol. – 1996. – Vol. 6, N 2. – P. 609-618.</mixed-citation><mixed-citation xml:lang="en">Livak F., Schatz D.G. T-cell receptor α locus V(D)J recombination by-products are abundant in thymocytes and mature T cells // Mol. Cell. Biol. – 1996. – Vol. 6, N 2. – P. 609-618.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lloyd C.M., Hessel E.M. Function of T cells in asthma: more than just Th2 cells // Nat. Rev. Immunol. – 2010. – Vol. 10. – P. 838-848.</mixed-citation><mixed-citation xml:lang="en">Lloyd C.M., Hessel E.M. Function of T cells in asthma: more than just Th2 cells // Nat. Rev. Immunol. – 2010. – Vol. 10. – P. 838-848.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nobile M., Correa R., Borqhans J.A., D’Aqostino C., Schneider P., De Boer R.J., Pantaleo G. De novo T-cell generation in patients at different ages and stages of HIV-1 disease // Blood. – 2004. – Vol. 104, N 2. – P. 470-477.</mixed-citation><mixed-citation xml:lang="en">Nobile M., Correa R., Borqhans J.A., D’Aqostino C., Schneider P., De Boer R.J., Pantaleo G. De novo T-cell generation in patients at different ages and stages of HIV-1 disease // Blood. – 2004. – Vol. 104, N 2. – P. 470-477.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rochman I., Watanabe N., Arima K., Liu Y.J., Leonard W.J. Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+T cells // J. Immunol. – 2007. – Vol. 178, N 11. – P. 6720-6724.</mixed-citation><mixed-citation xml:lang="en">Rochman I., Watanabe N., Arima K., Liu Y.J., Leonard W.J. Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+T cells // J. Immunol. – 2007. – Vol. 178, N 11. – P. 6720-6724.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yamanaka K-i., Yawalkar N., Jones D.A., Hurwitz D. Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma // Clin. Cancer Res. – 2005. – Vol. 11. – P. 5748-5754.</mixed-citation><mixed-citation xml:lang="en">Yamanaka K-i., Yawalkar N., Jones D.A., Hurwitz D. Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma // Clin. Cancer Res. – 2005. – Vol. 11. – P. 5748-5754.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
