<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2012-1-2-149-152</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-318</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SHORT COMMUNICATIONS</subject></subj-group></article-categories><title-group><article-title>СПОНТАННЫЙ АПОПТОЗ ЛИМФОЦИТОВ ПЕРИФЕРИЧЕСКОЙ КРОВИ У ПАЦИЕНТОВ С БОЛЕЗНЬЮ ПАРКИНСОНА</article-title><trans-title-group xml:lang="en"><trans-title>INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пчелина</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Pchelina</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>197089, Санкт-Петербург, ул. Л. Толстого, 6/8. Тел./факс: (812) 347-55-46.</p></bio><email xlink:type="simple">sopchelina@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усенко</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Usenko</surname><given-names>T. S.</given-names></name></name-alternatives><email xlink:type="simple">sopchelina@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боганькова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogankova</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">sopchelina@hotmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Якимовский</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakimovskii</surname><given-names>A. F.</given-names></name></name-alternatives><email xlink:type="simple">sopchelina@hotmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Емельянов</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Emelyanov</surname><given-names>A. K.</given-names></name></name-alternatives><email xlink:type="simple">sopchelina@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вавилова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vavilova</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">sopchelina@hotmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шварцман</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Shvartsman</surname><given-names>A. L.</given-names></name></name-alternatives><email xlink:type="simple">sopchelina@hotmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ПИЯФ РАН им. Б.П. Константинова, г. Гатчина&#13;
&#13;
СПбГМУ им. акад. И.П. Павлова, Санкт-Петербург</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>СПбГМА им. И.И. Мечникова, Санкт-Петербург</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>СПбГМУ им. акад. И.П. Павлова, Санкт-Петербург</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>ПИЯФ РАН им. Б.П. Константинова, г. Гатчина</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2014</year></pub-date><volume>14</volume><issue>1-2</issue><fpage>149</fpage><lpage>152</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пчелина С.Н., Усенко Т.С., Боганькова Н.А., Якимовский А.Ф., Емельянов А.К., Вавилова Т.В., Шварцман А.Л., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Пчелина С.Н., Усенко Т.С., Боганькова Н.А., Якимовский А.Ф., Емельянов А.К., Вавилова Т.В., Шварцман А.Л.</copyright-holder><copyright-holder xml:lang="en">Pchelina S.N., Usenko T.S., Bogankova N.A., Yakimovskii A.F., Emelyanov A.K., Vavilova T.V., Shvartsman A.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/318">https://www.mimmun.ru/mimmun/article/view/318</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>болезнь Паркинсона</kwd><kwd>апоптоз</kwd><kwd>лимфоциты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Parkinson’s disease</kwd><kwd>apoptosis</kwd><kwd>lymphocytes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Натвиг Дж.Б., Перлманн П., Визгель Х. Лимфоциты: выделение, фракционирование и характеристика. – М.: Медицина, 1980. – 416 с.</mixed-citation><mixed-citation xml:lang="en">Натвиг Дж.Б., Перлманн П., Визгель Х. Лимфоциты: выделение, фракционирование и характеристика. – М.: Медицина, 1980. – 416 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Скоромец А.А., Скоромец А.П., Скоромец Т.А. Нервные болезни. – М.: МЕДпресс-информ, 2005. – 544 с.</mixed-citation><mixed-citation xml:lang="en">Скоромец А.А., Скоромец А.П., Скоромец Т.А. Нервные болезни. – М.: МЕДпресс-информ, 2005. – 544 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Уразова О. И., Кравец Е.Б., Новицкий В.В, Рогалева А.В., Будкина Т.Е., Синюкова О.А., Недосекова Ю.В., Кузнецова В.Н. Апоптоз лимфоцитов крови у больных аутоиммунными тиреопатиями // Медицинская иммунология. – 2008. – Т. 10, № 2-3. – С. 187-192.</mixed-citation><mixed-citation xml:lang="en">Уразова О. И., Кравец Е.Б., Новицкий В.В, Рогалева А.В., Будкина Т.Е., Синюкова О.А., Недосекова Ю.В., Кузнецова В.Н. Апоптоз лимфоцитов крови у больных аутоиммунными тиреопатиями // Медицинская иммунология. – 2008. – Т. 10, № 2-3. – С. 187-192.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Aktas O., Ullrich O., Infante-Duarte C. Neuronal damage in brain inflammation // Arch Neurol. – 2007. – Vol. 64, N 2. – P. 185-189.</mixed-citation><mixed-citation xml:lang="en">Aktas O., Ullrich O., Infante-Duarte C. Neuronal damage in brain inflammation // Arch Neurol. – 2007. – Vol. 64, N 2. – P. 185-189.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bas J., Calopa M., Mestre M. Lymphocyte populations in Parkinson’s disease and in rat models of parkinsonism // J. Neuroimmunol. – 2001. – Vol. 113, N 1. – P. 146-152.</mixed-citation><mixed-citation xml:lang="en">Bas J., Calopa M., Mestre M. Lymphocyte populations in Parkinson’s disease and in rat models of parkinsonism // J. Neuroimmunol. – 2001. – Vol. 113, N 1. – P. 146-152.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Blandini F., Mangiagalli A., Cosentino M., Marino F. Peripheral markers of apoptosis in Parkinson’s disease: the effect of dopaminergic drugs // Ann N Y Acad. Sci. – 2003. – Vol. 1010. – P. 675-678.</mixed-citation><mixed-citation xml:lang="en">Blandini F., Mangiagalli A., Cosentino M., Marino F. Peripheral markers of apoptosis in Parkinson’s disease: the effect of dopaminergic drugs // Ann N Y Acad. Sci. – 2003. – Vol. 1010. – P. 675-678.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Calopa M., Bas J., Callen A., Mestre M. Apoptosis of peripheral blood lymphocytes in Parkinson patients // Neurobiol Dis. – 2010. – Vol. 38, N 1. – P. 1-7.</mixed-citation><mixed-citation xml:lang="en">Calopa M., Bas J., Callen A., Mestre M. Apoptosis of peripheral blood lymphocytes in Parkinson patients // Neurobiol Dis. – 2010. – Vol. 38, N 1. – P. 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Caronti B., Antonini C., Calderaro C. Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson’s disease. // J. Neural Transm. – 2001. – Vol. 108. – P. 803-807.</mixed-citation><mixed-citation xml:lang="en">Caronti B., Antonini C., Calderaro C. Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson’s disease. // J. Neural Transm. – 2001. – Vol. 108. – P. 803-807.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Carotini B., Tanda G., Colosimo C. Reduced dopamine in peripheral blood lymphocytes in Parkinson’s disease // NeuroReport. –1999. – Vol. 10. – P. 2907-2920.</mixed-citation><mixed-citation xml:lang="en">Carotini B., Tanda G., Colosimo C. Reduced dopamine in peripheral blood lymphocytes in Parkinson’s disease // NeuroReport. –1999. – Vol. 10. – P. 2907-2920.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Colombo C., Cosentino M., Marino F. Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells // Ann. N. Y. Acad Sci. – 2003. – Vol. 1010. – P. 679-682.</mixed-citation><mixed-citation xml:lang="en">Colombo C., Cosentino M., Marino F. Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells // Ann. N. Y. Acad Sci. – 2003. – Vol. 1010. – P. 679-682.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fukae J., Sato S., Shiba K., Sato K. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson’s disease // FEBS Lett. – 2003. – Vol. 3. – P. 521-525.</mixed-citation><mixed-citation xml:lang="en">Fukae J., Sato S., Shiba K., Sato K. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson’s disease // FEBS Lett. – 2003. – Vol. 3. – P. 521-525.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kim S., Beom S.. Jeon Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson’s disease // The FASEB Journal. – 2009. – Vol. 13. – P. 1615-1618.</mixed-citation><mixed-citation xml:lang="en">Kim S., Beom S.. Jeon Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson’s disease // The FASEB Journal. – 2009. – Vol. 13. – P. 1615-1618.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Moos T., Jensen P.H. Absence of prostate apoptosis response-4 protein in substantia nigra of Parkinson's disease autopsies // Acta Neuropathol. – 2004. – Vol. 1. – P. 23-26.</mixed-citation><mixed-citation xml:lang="en">Moos T., Jensen P.H. Absence of prostate apoptosis response-4 protein in substantia nigra of Parkinson's disease autopsies // Acta Neuropathol. – 2004. – Vol. 1. – P. 23-26.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pchelina S.N., Yakimovskii A.F., Emelyanov A.K., Ivanova O.N., Schwarzman A.L., Singleton A.B. Screening for LRRK2 mutations in patients with Parkinson’s disease in Russia: identification of a novel LRRK2 variant // Eur. J. Neurol. – 2008. – Vol. 15. – P. 692-696.</mixed-citation><mixed-citation xml:lang="en">Pchelina S.N., Yakimovskii A.F., Emelyanov A.K., Ivanova O.N., Schwarzman A.L., Singleton A.B. Screening for LRRK2 mutations in patients with Parkinson’s disease in Russia: identification of a novel LRRK2 variant // Eur. J. Neurol. – 2008. – Vol. 15. – P. 692-696.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pellicano M., Bulati M., Buffa S. Systemic immune responses in Alzheimer’s disease: in vitro mononuclear cell activation and cytokine production // J. Alzheimers Dis. – 2010. – Vol. 21, N 1. – P. 181-192.</mixed-citation><mixed-citation xml:lang="en">Pellicano M., Bulati M., Buffa S. Systemic immune responses in Alzheimer’s disease: in vitro mononuclear cell activation and cytokine production // J. Alzheimers Dis. – 2010. – Vol. 21, N 1. – P. 181-192.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Schaefer S., Vogt T., Nowak T., Kann P.H., German KIMS board. Pituitary function and the somatotrophic system in patients with idiopathic Parkinson’s disease under chronic dopaminergic therapy // J. Neuroendocrinol. – 2008. – Vol. 20, N 1. – P. 104-109.</mixed-citation><mixed-citation xml:lang="en">Schaefer S., Vogt T., Nowak T., Kann P.H., German KIMS board. Pituitary function and the somatotrophic system in patients with idiopathic Parkinson’s disease under chronic dopaminergic therapy // J. Neuroendocrinol. – 2008. – Vol. 20, N 1. – P. 104-109.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Tatton N.A. Incresed caspase 3 and BAX immunoreactivity accompany nuclear GAPGH translocation and neuronal apoptosis in Parkinson disease // Exp. Neurol. – 2000. – Vol. 166. – P. 29-43.</mixed-citation><mixed-citation xml:lang="en">Tatton N.A. Incresed caspase 3 and BAX immunoreactivity accompany nuclear GAPGH translocation and neuronal apoptosis in Parkinson disease // Exp. Neurol. – 2000. – Vol. 166. – P. 29-43.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Vermes I., Haanen C., Reutelingsperger C. Flow cytometry of apoptotic cell death // J Immunol Methods. 2000 – Vol. 243. – P. 167-190.</mixed-citation><mixed-citation xml:lang="en">Vermes I., Haanen C., Reutelingsperger C. Flow cytometry of apoptotic cell death // J Immunol Methods. 2000 – Vol. 243. – P. 167-190.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada M., Kida K., Amutuhaire W., Ichinose F., Kaneki M. Gene disruption of caspase-3 prevents MPTP-induced Parkinson’s disease in mice. Biochem Biophys // Res. Commun. – 2010. – Vol. 402, N 2. – P. 312-318.</mixed-citation><mixed-citation xml:lang="en">Yamada M., Kida K., Amutuhaire W., Ichinose F., Kaneki M. Gene disruption of caspase-3 prevents MPTP-induced Parkinson’s disease in mice. Biochem Biophys // Res. Commun. – 2010. – Vol. 402, N 2. – P. 312-318.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Yang Q., Mao Z. Parkinson disease: a role for autophagy // Neuroscientist. – 2010. – Vol. 16, N 4. – P. 335-341.</mixed-citation><mixed-citation xml:lang="en">Yang Q., Mao Z. Parkinson disease: a role for autophagy // Neuroscientist. – 2010. – Vol. 16, N 4. – P. 335-341.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
