mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-2012-1-2-87-94mimmun-301Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПОЛИМОРФИЗМ ГЕНА VEGFA (С-2578A, C+936T) У ПАЦИЕНТОК С РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫVEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCERШевченкоА. В.ShevchenkoA. V.
630117, г. Новосибирск, ул. Академика Тимакова, 2. Тел.: (383) 227-01-94. Факс: (383) 227-01-96.
shalla64@mail.ruКоненковВ. И.KonenkovV. I.shalla64@mail.ruГоловановаО. В.GolovanovaO. V.shalla64@mail.ruБлагодатскихА. Е.BlagodatskikhA. E.shalla64@mail.ruГарбуковЕ. Ю.GarbukovE. Yu.shalla64@mail.ruСтахееваМ. Н.StakheevaM. N.shalla64@mail.ruУчреждение Российской академии медицинских наук НИИ Клинической и Экспериментальной лимфологии СО РАМН, г. НовосибирскRussian FederationУчреждение Российской академии медицинских наук НИИ онкологии Томского научного центра СО РАМН, г. ТомскRussian Federation201219072014141-28794Copyright © Шевченко А.В., Коненков В.И., Голованова О.В., Благодатских А.Е., Гарбуков Е.Ю., Стахеева М.Н., 20142014Шевченко А.В., Коненков В.И., Голованова О.В., Благодатских А.Е., Гарбуков Е.Ю., Стахеева М.Н.Shevchenko A.V., Konenkov V.I., Golovanova O.V., Blagodatskikh A.E., Garbukov E.Y., Stakheeva M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/301рак молочной железыполиморфизм VEGFAлимфагенное метастазированиеменструальный статусbreast cancerVEGFA gene polymorphismlymphogenic metastasesmenstrual statusReferencesAbe A., Sato K., Habuchi T., Wang L., Li Z., Tsuchiya N., Ohyama C., Satoh S., Ogawa O., Kato T.. Single nucleotide polymorphisms in the 3` untranslated region of vascular endothelial growth factor gene in Japanese population with or without renal cell carcinom // Tohoku J. Exp Med. – 2002. – Vol. 198. – P. 181-190.Abe A., Sato K., Habuchi T., Wang L., Li Z., Tsuchiya N., Ohyama C., Satoh S., Ogawa O., Kato T.. Single nucleotide polymorphisms in the 3` untranslated region of vascular endothelial growth factor gene in Japanese population with or without renal cell carcinom // Tohoku J. Exp Med. – 2002. – Vol. 198. – P. 181-190.Aldridge S.E., Lennard T.W.J., Williams J.R., Birch M.A. Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bo // British Journal of Cancer. – 2005. – Vol. 92. – P. 1531-1537.Aldridge S.E., Lennard T.W.J., Williams J.R., Birch M.A. Vascular endothelial growth factor acts as an osteolytic factor in breast cancer metastases to bo // British Journal of Cancer. – 2005. – Vol. 92. – P. 1531-1537.Awata T., Inoue K., Kurihara S., Tomoko O., Masaki W., Kouichi I., Ikuo I., Shigehiro K. A common polymorphism in the 5`-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabete // Diabetes. – 2002. – Vol. 51. – P. 1635-1639.Awata T., Inoue K., Kurihara S., Tomoko O., Masaki W., Kouichi I., Ikuo I., Shigehiro K. A common polymorphism in the 5`-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabete // Diabetes. – 2002. – Vol. 51. – P. 1635-1639.Banyasz I., Szabo S., Bokodi G., Vannay A ., Vasarhelyi B., Szabo A., Tulassay T., Rigo J. Genetic polymorphisms of vascular endothelial growth factor in severe pre-eclampsi // Molecular Human Reproduction. – 2006. – Vol. 12 (4). – P. 233-236.Banyasz I., Szabo S., Bokodi G., Vannay A ., Vasarhelyi B., Szabo A., Tulassay T., Rigo J. Genetic polymorphisms of vascular endothelial growth factor in severe pre-eclampsi // Molecular Human Reproduction. – 2006. – Vol. 12 (4). – P. 233-236.Bland J.M., Altman D.G. Education and debate. The odds rati // BMJ. – 2000. – Vol. 320. – P. 1468.Bland J.M., Altman D.G. Education and debate. The odds rati // BMJ. – 2000. – Vol. 320. – P. 1468.Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases // Nature. – 2000. – Vol. 407. – P. 249-257.Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases // Nature. – 2000. – Vol. 407. – P. 249-257.Carron S.L., Edwards S., Evans P.R., Gibbs R., Dearnaley D.P., Dowe A., Southgate C., Easton D.F., Eeles R.A., Howell W.M. Influence of cytokine gene polymorphisms on the development of prostate cance // Cancer Res. – 2002. – Vol. 62. – P. 3369-3372.Carron S.L., Edwards S., Evans P.R., Gibbs R., Dearnaley D.P., Dowe A., Southgate C., Easton D.F., Eeles R.A., Howell W.M. Influence of cytokine gene polymorphisms on the development of prostate cance // Cancer Res. – 2002. – Vol. 62. – P. 3369-3372.Clar H., Krippl P., Renner W., Langsenlehner T., Clar V., Windhager R., Langsenlehn U. Association of polymorphisms of angiogenesis genes with breast cance // Breast Cancer Rec Treat. – 2009. – Vol. 113. – P. 197-198.Clar H., Krippl P., Renner W., Langsenlehner T., Clar V., Windhager R., Langsenlehn U. Association of polymorphisms of angiogenesis genes with breast cance // Breast Cancer Rec Treat. – 2009. – Vol. 113. – P. 197-198.Ferrara N., Gerber H.P. The role of vascular endothelial growth factor in angiogenesis // Acta Haematol. – 2001. – Vol. 106. – P. 148-156.Ferrara N., Gerber H.P. The role of vascular endothelial growth factor in angiogenesis // Acta Haematol. – 2001. – Vol. 106. – P. 148-156.Ferrara N., Gerber H.P., Le Couter J.. The biology of VEGF and its receptors // Nat Med. – 2003. – Vol. 9. – P. 669-676.Ferrara N., Gerber H.P., Le Couter J.. The biology of VEGF and its receptors // Nat Med. – 2003. – Vol. 9. – P. 669-676.Foekens J.A., Peters H.A., Grebenchtchikov N., Look M.P., Meijer-van Gelder M.E., Geurts-Moespot A., van der Kwast T.H., Sweep C.G.J., Klijn J.G.M. High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cance // Cancer Res. – 2001. – Vol. 61. – P. 5407-5414.Foekens J.A., Peters H.A., Grebenchtchikov N., Look M.P., Meijer-van Gelder M.E., Geurts-Moespot A., van der Kwast T.H., Sweep C.G.J., Klijn J.G.M. High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cance // Cancer Res. – 2001. – Vol. 61. – P. 5407-5414.Hadaschik D., Hinterkeuser K., Oldak M., Pfister H.J., Smola-Hess S. The Papillomavirus E2 protein binds to and synergizes with C/EBP factors involved in keratinocyte differentiatio // J. Virol. – 2003. – Vol. 77. – P. 5253-5265.Hadaschik D., Hinterkeuser K., Oldak M., Pfister H.J., Smola-Hess S. The Papillomavirus E2 protein binds to and synergizes with C/EBP factors involved in keratinocyte differentiatio // J. Virol. – 2003. – Vol. 77. – P. 5253-5265.Howell W.M., Bateman A.C., Turner S.J., Collins A., Theaker J.M. Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanom // Genes Immun. – 2002. – Vol. 3. – P. 229-232.Howell W.M., Bateman A.C., Turner S.J., Collins A., Theaker J.M. Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanom // Genes Immun. – 2002. – Vol. 3. – P. 229-232.Jacobs E. J., Feigelson H. S., Bain E.B., Brady K.A., Rodriguez C., Stevens V.L., Patel A.V., Thun M.J., Calle E.E. Рolymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohor // Breast Cancer Research. – 2006. – Vol. 8(22). – http:// breast-cancer-research.com/content/8/2/R22Jacobs E. J., Feigelson H. S., Bain E.B., Brady K.A., Rodriguez C., Stevens V.L., Patel A.V., Thun M.J., Calle E.E. Рolymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohor // Breast Cancer Research. – 2006. – Vol. 8(22). – http:// breast-cancer-research.com/content/8/2/R22Jin Q., Hemminki K., Enquist K., Lenner P., Grzybowska E., Klaes R., Henriksson R., Chen B., Pamula J., Pekala W., Zientek H., Rogozinska-Szczepka J., Utracka-Hutka B., Hallmans G., Forsti A. Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis // Clin Cancer Res. – 2005. – Vol. 11. – P. 3647-3653.Jin Q., Hemminki K., Enquist K., Lenner P., Grzybowska E., Klaes R., Henriksson R., Chen B., Pamula J., Pekala W., Zientek H., Rogozinska-Szczepka J., Utracka-Hutka B., Hallmans G., Forsti A. Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis // Clin Cancer Res. – 2005. – Vol. 11. – P. 3647-3653.Kim J.K., Oh D., Kwak S.Y., Han J.H., Chung Y.S., Kim N.K. Genetic Polymorphism of Vascular Endothelial Growth Factor (VEGF C936T) in the Korean Populati // Korean J. Biol Sci. – 2003. – Vol. 7. – P. 261-264.Kim J.K., Oh D., Kwak S.Y., Han J.H., Chung Y.S., Kim N.K. Genetic Polymorphism of Vascular Endothelial Growth Factor (VEGF C936T) in the Korean Populati // Korean J. Biol Sci. – 2003. – Vol. 7. – P. 261-264.Krippl P., Langsenlehner U., Renner W., Yazdani-Biuki B., Wolf G., Wascher T.C., Paulweber B., Haas J., Samonigg H. A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer ris // Int J. Cancer. – 2003. – Vol. 106. – P. 468-471.Krippl P., Langsenlehner U., Renner W., Yazdani-Biuki B., Wolf G., Wascher T.C., Paulweber B., Haas J., Samonigg H. A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer ris // Int J. Cancer. – 2003. – Vol. 106. – P. 468-471.Krippl P., Langsenlehner U., Samonigg H., Renner W., Koppel H. Vascular Endothelial Growth Factor in Predicting Outcome in Breast Cance // Clin Cancer Res. – 2004. – Vol. 10. – P. 8752-8753.Krippl P., Langsenlehner U., Samonigg H., Renner W., Koppel H. Vascular Endothelial Growth Factor in Predicting Outcome in Breast Cance // Clin Cancer Res. – 2004. – Vol. 10. – P. 8752-8753.Lynn K.D., Roland C.L., Brekken R.A. VEGF and Pleiotrophin Modulate the Immune Profile of Breast Canc // Cancers. – 2010. – Vol. 2. – P. 970-988.Lynn K.D., Roland C.L., Brekken R.A. VEGF and Pleiotrophin Modulate the Immune Profile of Breast Canc // Cancers. – 2010. – Vol. 2. – P. 970-988.Mazumder B., Seshadri V., Fox P.L. Translational control by the 3`-UTR: the ends specify the means // Trends Biochem Sci. – 2003. – Vol. 28. – P. 91-98.Mazumder B., Seshadri V., Fox P.L. Translational control by the 3`-UTR: the ends specify the means // Trends Biochem Sci. – 2003. – Vol. 28. – P. 91-98.Mohammadi M., Ollier W.E., Hutchinson I.V. A functional association study of VEGF gene promoter polymorphisms with VEGF expression by stimulated pbm cell // Hum Immunol. – 2003. – Vol. 64. – P. 125.Mohammadi M., Ollier W.E., Hutchinson I.V. A functional association study of VEGF gene promoter polymorphisms with VEGF expression by stimulated pbm cell // Hum Immunol. – 2003. – Vol. 64. – P. 125.Nobuhiko K., Qiuyin C., Wanqing W., Xiao-Ou S., Fan J., Yu-Tang G., Wei Z. Population-Based Case-Control Study of VEGF Gene Polymorphisms and Breast Cancer Risk among Chinese Wome // Cancer Epidemiol Biomarkers Prev. – 2006. – Vol. 15. – P. 1148-1152.Nobuhiko K., Qiuyin C., Wanqing W., Xiao-Ou S., Fan J., Yu-Tang G., Wei Z. Population-Based Case-Control Study of VEGF Gene Polymorphisms and Breast Cancer Risk among Chinese Wome // Cancer Epidemiol Biomarkers Prev. – 2006. – Vol. 15. – P. 1148-1152.Renner W., Kotschan S., Hoffmann C., Obermayer-Pietsch B., Pilger E. A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma level // J. Vasc Res. – 2000. – Vol. 37. – P. 443-448.Renner W., Kotschan S., Hoffmann C., Obermayer-Pietsch B., Pilger E. A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma level // J. Vasc Res. – 2000. – Vol. 37. – P. 443-448.Shahbazi M., Fryer A.A., Pravica V., Brogan I.J., Ramsay H.M., Hutchinson I.V., Harden P.N. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejectio // J. Am. Soc. Nephrol. – 2002. – Vol. 13. – P. 260-264.Shahbazi M., Fryer A.A., Pravica V., Brogan I.J., Ramsay H.M., Hutchinson I.V., Harden P.N. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejectio // J. Am. Soc. Nephrol. – 2002. – Vol. 13. – P. 260-264.Smith K.C., Bateman A.C., Fussell H.M., Howell W.M. Cytokine gene polymorphisms and breast cancer susceptibility and prognosi // Eur. J. Immunogenet. – 2004. – Vol. 31. – P. 167-173.Smith K.C., Bateman A.C., Fussell H.M., Howell W.M. Cytokine gene polymorphisms and breast cancer susceptibility and prognosi // Eur. J. Immunogenet. – 2004. – Vol. 31. – P. 167-173.Vincenti V., Cassano C., Rocchi M., Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3 // Circulation. – 1996. – Vol. 93. – P. 1493-1495.Vincenti V., Cassano C., Rocchi M., Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3 // Circulation. – 1996. – Vol. 93. – P. 1493-1495.Watson C.J., Webb N.J., Bottomley M.J., Brenchley P.E. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene:correlation with variation in VEGF protein productio // Cytokine . – 2000. – Vol. 12. – P. 1232-1235.Watson C.J., Webb N.J., Bottomley M.J., Brenchley P.E. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene:correlation with variation in VEGF protein productio // Cytokine . – 2000. – Vol. 12. – P. 1232-1235.
The authors declare that there are no conflicts of interest present.