mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-PAP-3008mimmun-3008Research ArticleОБЗОРЫREVIEWSТромбоциты и их микровезикулы: фенотип, состав, влияние на эндотелийPlatelets and platelet-derived microvesicles: Phenotype, content, impact on endothelial cellsСтепановаО. И.StepanovaO. I.

младший научный сотрудник лаборатории межклеточных взаимодействий 

Junior Researcher, Laboratory of Intercellular Interactions

alzass@mail.ruhttps://orcid.org/0000-0002-6976-7061ПеревязкинаМ. А.PereviazkinaM. A.

лаборант-исследователь лаборатории межклеточных взаимодействий; лаборант-исследователь лаборатории молекулярной иммунологии 

Laboratory Assistant, Laboratory of Intercellular Interactions; Laboratory Assistant, Laboratory of Molecular Immunology

marinaperev17@mail.ruМарковаК. Л.MarkovaK. L.

младший научный сотрудник лаборатории межклеточных взаимодействий 

Junior Researcher, Laboratory of Intercellular Interactions

kl.markova94@gmail.comСельковС. А.SelkovS. A.

д.м.н., профессор, заслуженный деятель науки РФ, главный научный сотрудник отдела иммунологии и межклеточных взаимодействий; профессор кафедры иммунологии 

PhD, MD (Medicine), Professor, Honored Scientist of the Russian Federation, Chief Researcher, Department of Immunology and Intercellular Interactions; Professor, Department of Immunology

selkovsa@mail.ruСоколовД. И.SokolovD. I.

д.б.н., доцент, заведующий отделом иммунологии и межклеточных взаимодействий; ведущий научный сотрудник лаборатории молекулярной иммунологии; профессор кафедры иммунологии 

PhD, MD (Biology), Associate Professor, Head, Department of Immunology and Intercellular Interactions; Leading Researcher, Laboratory of Molecular Immunology; Professor, Department of Immunology

falcojugger@yandex.ruФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта»РоссияD. Ott Research Institute of Obstetrics, Gynecology and Reproductive MedicineRussian FederationФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта»; ФБУН «Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияD. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine; Saint Petersburg Pasteur InstituteRussian FederationФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта»; ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения РФРоссияD. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine; First St. Petersburg State I. Pavlov Medical UniversityRussian FederationФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта»; ФБУН «Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека; ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения РФРоссияD. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine; Saint Petersburg Pasteur Institute; First St. Petersburg State I. Pavlov Medical UniversityRussian Federation20252012202527612191246Copyright © Степанова О.И., Перевязкина М.А., Маркова К.Л., Сельков С.А., Соколов Д.И., 20252025Степанова О.И., Перевязкина М.А., Маркова К.Л., Сельков С.А., Соколов Д.И.Stepanova O.I., Pereviazkina M.A., Markova K.L., Selkov S.A., Sokolov D.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/3008

Тромбоциты – это небольшие постклеточные элементы мегакариоцитов, циркулирующие в крови. На их поверхности представлены молекулы межклеточной адгезии, Toll-подобные рецепторы, рецепторы хемокинов и цитокинов и другие. Тромбоциты содержат соединения с разнообразной биологической функцией, в том числе хемокины, цитокины и ростовые факторы. Благодаря особенностям цитологического строения – мембранной системе и секреторным гранулам – тромбоциты способны быстро активироваться и вступать во взаимодействие с другими клетками. Тромбоциты участвуют в гемостазе, иммунных реакциях, ангиогенезе. Активация, необходимая тромбоцитам для выполнения своих функций, опосредуется через ионы кальция и может инициироваться компонентами субэндотелия, белками системы комплемента, продуктами секреции других тромбоцитов. При активации тромбоциты высвобождают секреторные гранулы, изменяют морфологию. Помимо этого, тромбоциты, подобно другим клеткам организма, в норме и при патологии продуцируют микровезикулы – сравнительно новый объект, интенсивное изучение которого ведется в настоящее время. Целью настоящего обзора явилось сравнительное описание тромбоцитов и их микровезикул, которым тромбоциты делегируют некоторые свои функции как посредникам коммуникации с другими клетками, в том числе эндотелиоцитами. Микровезикулы являются перспективным объектом исследования, изучается возможность их использования в качестве диагностического и терапевтического агента. Наибольшая часть микровезикул, циркулирующих в периферической крови, имеют тромбоцитарное происхождение. В составе микровезикул тромбоцитов присутствуют цитокины и другие белки, липиды и нуклеиновые кислоты (ДНК, мРНК, микроРНК). На поверхности микровезикул тромбоцитов сохраняются поверхностные маркеры родительских клеток; на их мембране представлен фосфатидилсерин, который дополнительно участвует в тромбообразовании за счет аккумулирования факторов коагуляции. Под влиянием сигналов микроокружения состав, фенотип тромбоцитарных микровезикул, а также их функциональная направленность в отношении эндотелия может варьировать в зависимости от стимула. Эффект, оказываемый ими на ангиогенез и регенерацию, недостаточно изучен, экспериментальные данные демонстрируют как положительное, так и отрицательное влияние. При различных патологиях, сопровождающихся эндотелиальной дисфункцией (сердечно-сосудистые патологии, преэклампсия, диабет), наблюдается повышение уровня тромбоцитарных микровезикул, что указывает на их возможное участие в патогенезе заболеваний. Тем не менее влияние тромбоцитов и их микровезикул на эндотелий, в том числе активации в эндотелии различных сигнальных путей, остается предметом дальнейших исследований.

Blood platelets are circulating anuclear structures derived from megakaryocytes. Intercellular adhesion molecules, Toll-like receptors, chemokine and cytokine receptors are represented on their surface. Platelets contain biologically active molecules, including chemokines, cytokines, and growth factors. Due to their cytological features (membranes and secretory granules), the platelets are capable of fast activation and interactions with different cells. Platelets are involved in hemostasis, immune reactions, and angiogenesis, being activated by sub-endothelial components, complement proteins, secretion products from other platelets. The activation is mediated via calcium ions. Upon these events, the platelets change their morphology, release secretory granules and produce microvesicles, a relatively new target of biological research. The aim of this review is a comparative description of platelets and their microvesicles. Platelet-derived microvesicles perform platelets functions and communicate with other cells, including endothelium. Microvesicles represent a promising object of research, and the opportunities of their applications for diagnostics and therapy are being actively studied. Majority of circulating microvesicles are of platelet origin. The platelet-derived microvesicles contain cytokines and other proteins, lipids and nucleic acids (DNA, mRNA, microRNA). Microvesicles bear the surface markers of parental cells; phosphatidylserine is represented on their membrane, which additionally participates in clotting, due to deposition of blood coagulation factors. Under the influence of signals from microenvironment, the composition, phenotype of platelet microvesicles, as well as their functional abilities towards endothelium may vary, depending on the actual stimuli. Their effects upon angiogenesis and regeneration have not been sufficiently elucidated, with controversial effects reported in experimental studies. Increased levels of platelet microvesicles are observed in the disorders accompanied by endothelial dysfunction, thus suggesting their possible participation in these events. The effects of platelets and their microvesicles on endothelium, including activation of various signaling pathways in endothelial cells, still remain the subject of further research.

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The authors declare that there are no conflicts of interest present.