mimmunМедицинская иммунологияMedical Immunology (Russia)1563-06252313-741XSPb RAACI10.15789/1563-0625-EOL-2928mimmun-2928Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОценка липидного профиля при хронической спонтанной крапивницеEvaluation of lipid profiles in patients with chronic spontaneous urticaria: A case-control studyhttps://orcid.org/0000-0001-9027-5144ХалилиАббасKhaliliAbbas

Аббас Халили – д.м.н., доцент Университета медицинских наук Шахида Садуги, отделение педиатрии, Больница Шахида Садуги 

Йезд

Abbas Khalili, MD, Associate Professor of Shahid Sadoughi University of Medica Sciences, Department of Pediatrics, Shahid Sadoughi Hospital 

Yazd

abbas_khalili_30@yahoo.comhttps://orcid.org/0009-0006-3322-0140Азади Талаб ДавудабадиФатимеAzadi Talab DavoudabadiFatemeh

Фатиме Азади Талаб Давудабади – д.м.н., врач общей практики, отделение педиатрии, Больница Шахида Садуги 

Йезд

Fatemeh Azadi Talab Davoudabadi, MD, General Physician, Department of Pediatrics, Shahid Sadoughi Hospital 

Yazd

Fatemehazaditalab@gmail.comhttps://orcid.org/0000-0003-4918-6494СадегиБамдадSadeghiBamdad

Бамдад Садеги – д.м.н., врач общей практики Исследовательского центра иммунодефицитов Детского медицинского центра 

Тегеран

Bamdad Sadeghi, MD, General Physician, Research Center for Immunodeficiencies, Children’s Medical Center 

Tehran

b_sadeghi@razi.tums.ac.irУниверситет медицинских наук Шахида СадугиИранShahid Sadoughi University of Medical SciencesIslamic Republic of IranТегеранский университет медицинских наукИранUniversity of Medical SciencesIslamic Republic of Iran202516092024272329334Copyright © Халили А., Азади Талаб Давудабади Ф., Садеги Б., 20252025Халили А., Азади Талаб Давудабади Ф., Садеги Б.Khalili A., Azadi Talab Davoudabadi F., Sadeghi B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.mimmun.ru/mimmun/article/view/2928

Хроническая крапивница имеет рекуррентное течение, характеризуется зудом, эритемой, отеками слизистых оболочек в течение большей части недели на протяжении 6 недель или более. Есть предположение о том, что уровни и состав липидов крови могут вносить вклад в развитие или обострение крапивницы. Целью данной работы было исследование связи между хронической крапивницей и липидным составом крови. 50 пациентов с хронической крапивницей и 50 здоровых лиц были включены в исследование типа «случай-контроль». У пациентов с крапивницей проводилась оценка каждого параметра липидного профиля крови и тяжести крапивницы в 4 отдельных возрастных группах с учетом половых различий. Степень тяжести заболевания анализировали в связи с уровнями липопротеинов высокой плотности, липопротеинов низкой плотности, триглицеридов и холестерина. Уровни триглицеридов (p = 0,039), общего холестерина (p = 0,031) и липопротеинов низкой плотности (p = 0,001) были значительно выше у больных с крапивницей, нежели в контрольной группе. Не выявлено корреляций между тяжестью крапивницы (по шкале UAS7), возрастом и полом пациентов. Тяжесть крапивницы не различалась при сопоставлении с отдельными параметрами липидного профиля. Показано, что средние значения липопротеинов высокой плотности у больных с хронической крапивницей различного возраста существенно повышены у женщин по сравнению с мужчинами (p < 0,002). В нашем исследовании обранужена корреляция между наличием хронической крапивницы и гиерлипидемией. На основании этих данных можно рекомендовать исследование на гиперлипидемию у пациентов с хронической крапивницей.

Chronic urticaria is referred to recurrent, pruritic, erythematous, and edematous mucocutaneous lesions on most days of the week, and persists for six weeks or more. There is a hypothesis about the levels of blood lipid profiles in CSU, which may have a contributing role in development or exacerbation of hives attacks. The present study was conducted to investigate the association between chronic urticaria and blood lipid profiles. Fifty patients with chronic urticaria and fifty healthy people were included in this case-control study. In chronic urticaria patients, each parameters of blood lipid profile and urticaria severity were evaluated in each of four age and two sex cathegories. Urticaria severity in chronic urticaria patients, was also analyzed for levels of HDL, LDL, Triglyceride and Cholesterol. Levels of triglyceride (p value = 0.039), total cholesterol (p value = 0.031), and LDL (p value = 0.001) were significantly higher in chronic urticaria patients than in control group. No correlation was found between the urticaria severity (UAS7 score) average, and the age and sex of the patients. Urticaria severity showed no significant difference within each lipid profile parameter. Average values of lipid profiles in patients with chronic urticaria in different age and sex showed that HDL has remarkably higher mean quantitation in women than men (p < 0.002). Our study found a correlation between chronic urticaria with hyperlipidemia. According to this investigation, we can advise that patients with chronic urticaria should be evaluated for hyperlipidemia.

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The authors declare that there are no conflicts of interest present.